Search Results - "Stauffer, Philip"

The role of altered calcium signaling and handling as an underlying mechanism of drug tolerance in BRAF mutant melanoma by Stauffer, Philip E.

“…Molecularly‐targeted therapies in patients harboring well‐defined driver mutations have proven to be initially effective for many patients; however, tumor…”
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Coupled multiphase flow and transport simulation to model CO2 dissolution and local capillary trapping in permeability and capillary heterogeneous reservoir by Singh, Mrityunjay, Chaudhuri, Abhijit, Soltanian, Mohamad Reza, Stauffer, Philip H

“…•Numerical study of dissolution and local capillary trapping in heterogeneous reservoir.•We have simulated ScCO2 spread and solutal fingering, and calculated…”
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Simulation of Gravitational Instability and Thermo‐Solutal Convection During the Dissolution of CO 2 in Deep Storage Reservoirs by Singh, Mrityunjay, Chaudhuri, Abhijit, Stauffer, Philip H, Pawar, Rajesh J

“…The temperature of deep hydrothermal sedimentary reservoirs varies between 50 and 250 °C, while the temperature of injected CO 2 can be much below the…”
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Simulation of Gravitational Instability and Thermo‐Solutal Convection During the Dissolution of CO2 in Deep Storage Reservoirs by Singh, Mrityunjay, Chaudhuri, Abhijit, Stauffer, Philip H, Pawar, Rajesh J

“…The temperature of deep hydrothermal sedimentary reservoirs varies between 50 and 250 °C, while the temperature of injected CO2 can be much below the reservoir…”
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Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2 by Gotoh, Tetsuya, Kim, Jae Kyoung, Liu, Jingjing, Vila-Caballer, Marian, Stauffer, Philip E., Tyson, John J., Finkielstein, Carla V.

“…The circadian clock and cell cycle networks are interlocked on the molecular level, with the core clock loop exerting a multilevel regulatory role over cell…”
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Rethinking Porosity-Based Diffusivity Estimates for Sorptive Gas Transport at Variable Temperatures by Neil, Chelsea W., Swager, Katherine C., Bourret, S. Michelle, Ortiz, John P., Stauffer, Philip H.

“…The detection of noble gas radioisotopes following a suspected underground nuclear explosion is the surest indicator that nuclear detonation has occurred…”
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Discriminating Underground Nuclear Explosions Leading To Late‐Time Radionuclide Gas Seeps by Harp, Dylan R., Bourret, S. Michelle, Stauffer, Philip H., Kwicklis, Edward M.

“…Utilizing historical data from the U.S. nuclear test program and freely available barometric pressure data, we performed an analytical barometric‐pumping…”
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Characterizing the Impacts of Multi‐Scale Heterogeneity on Solute Transport in Fracture Networks by Sweeney, Matthew R., Hyman, Jeffrey D., O’Malley, Daniel, Santos, Javier E., Carey, J. William, Stauffer, Philip H., Viswanathan, Hari S.

“…We model flow and transport in fracture networks with varying degrees of fracture‐to‐fracture aperture heterogeneity and network intensity to show how changes…”
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Evaluation of several relevant fractionation processes as possible explanation for radioxenon isotopic activity ratios in samples taken near underground nuclear explosions in shafts and tunnels by Bourret, S. Michelle, Kwicklis, Edward M., Stauffer, Philip H.

“…Gas samples taken from two historic underground nuclear tests done in 1989 at the Nevada National Security Site (NNSS), formerly the Nevada Test Site (NTS),…”
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Simulation of Gravitational Instability and Thermo‐Solutal Convection During the Dissolution of CO in Deep Storage Reservoirs by Singh, Mrityunjay, Chaudhuri, Abhijit, Stauffer, Philip H, Pawar, Rajesh J

“…Abstract The temperature of deep hydrothermal sedimentary reservoirs varies between 50 and 250 °C, while the temperature of injected CO can be much below the…”
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The National Risk Assessment Partnership’s integrated assessment model for carbon storage: A tool to support decision making amidst uncertainty by Pawar, Rajesh J., Bromhal, Grant S., Chu, Shaoping, Dilmore, Robert M., Oldenburg, Curtis M., Stauffer, Philip H., Zhang, Yingqi, Guthrie, George D.

“…The US DOE-funded National Risk Assessment Partnership (NRAP) has developed an integrated assessment model (NRAP-IAM-CS) that can be used to simulate carbon…”
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The hydrothermal alteration of cooling lava domes by Ball, Jessica L., Stauffer, Philip H., Calder, Eliza S., Valentine, Greg A.

“…Hydrothermal alteration is a recognized cause of volcanic instability and edifice collapse, including that of lava domes or dome complexes. Alteration by…”
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Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied by Selfridge, Julia M., Gotoh, Tetsuya, Schiffhauer, Samuel, Liu, JingJing, Stauffer, Philip E., Li, Andrew, Capelluto, Daniel G. S., Finkielstein, Carla V.

“…Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be…”
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CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction by Perfitt, Tyler L., Stauffer, Philip E., Spiess, Keeley L., Colbran, Roger J.

“…Protein-protein interactions can be modulated by phosphorylation of either binding partner, thereby altering subcellular localization and/or physiological…”
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Identification of dominant gas transport frequencies during barometric pumping of fractured rock by Harp, Dylan R., Ortiz, John P., Stauffer, Philip H.

“…We demonstrate that although barometric pressures are complicated signals comprised of numerous frequencies, it is a subset of these frequencies that drive the…”
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Analysis of evolving capillary transition, gravitational fingering, and dissolution trapping of CO2 in deep saline aquifers during continuous injection of supercritical CO2 by Singh, Mrityunjay, Chaudhuri, Abhijit, Chu, Shaoping P, Stauffer, Philip H, Pawar, Rajesh J

“…•Evolution of ScCO2 and dissolved CO2 plume is modeled for constant CO2 injection rate.•Injection pressure that controls the shape of diffusive layer,…”
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Upscaled discrete fracture matrix model (UDFM): an octree-refined continuum representation of fractured porous media by Sweeney, Matthew R., Gable, Carl W., Karra, Satish, Stauffer, Philip H., Pawar, Rajesh J., Hyman, Jeffrey D.

“…We develop a computational geometry-based upscaling approach to accurately capture the dynamic processes occurring within and between subsurface fracture…”
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Potential CO2 and brine leakage through wellbore pathways for geologic CO2 sequestration using the National Risk Assessment Partnership tools: Application to the Big Sky Regional Partnership by Onishi, Tsubasa, Nguyen, Minh C., Carey, J. William, Will, Bob, Zaluski, Wade, Bowen, David W., Devault, Bryan C., Duguid, Andrew, Zhou, Quanlin, Fairweather, Stacey H., Spangler, Lee H., Stauffer, Philip H.

“…•Application of National Risk Assessment Partnership (NRAP) tools to geologic CO2 sequestration in the Kevin Dome in Montana.•Sensitivity analysis of various…”
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Purinergic Ca2+ Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma by Stauffer, Philip E., Brinkley, Jordon, Jacobson, David A., Quaranta, Vito, Tyson, Darren R.

“…Drug tolerance is a major cause of relapse after cancer treatment. Despite intensive efforts, its molecular basis remains poorly understood, hampering…”
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Pre-site Characterization Risk Analysis for Commercial-Scale Carbon Sequestration by Dai, Zhenxue, Stauffer, Philip H, Carey, J. William, Middleton, Richard S, Lu, Zhiming, Jacobs, John F, Hnottavange-Telleen, Ken, Spangler, Lee H

“…This study develops a probability framework to evaluate subsurface risks associated with commercial-scale carbon sequestration in the Kevin Dome, Montana…”
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