Search Results - "Stauffer, Fanny"

A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules by Laske, Stephan, Paudel, Amrit, Scheibelhofer, Otto

“…Pharmaceutical solid oral dosage product manufacturing is a well-established, yet revolutionizing area. To this end, process analytical technology (PAT)…”
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Analysis of the Influence of Process and Formulation Properties on the Drying Behavior of Pharmaceutical Granules in a Semi-Continuous Fluid Bed Drying System by Vandeputte, Tuur, Ghijs, Michael, Peeters, Michiel, De Man, Alexander, Van Hauwermeiren, Daan, Dos Santos Schultz, Eduardo, Vigh, Tamas, Stauffer, Fanny, Nopens, Ingmar, De Beer, Thomas

“…In the last decade, twin-screw wet granulation became an essential technology for continuous pharmaceutical tablet production. Consequently, interest in…”
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Sampling and diversion strategy for twin-screw granulation lines using batch statistical process monitoring by Stauffer, Fanny, Boulanger, Eliot, Pilcer, Gabrielle

“…Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications…”
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Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation by Peeters, Michiel, Alejandra Barrera Jiménez, Ana, Matsunami, Kensaku, Stauffer, Fanny, Nopens, Ingmar, De Beer, Thomas

“…[Display omitted] In recent years, continuous twin-screw wet granulation (TSWG) is gaining increasing interest from the pharmaceutical industry. Despite the…”
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Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics by Vandeputte, Tuur, Ghijs, Michael, Van Hauwermeiren, Daan, Dos Santos Schultz, Eduardo, Schäfer, Elisabeth, Stauffer, Fanny, De Beer, Thomas, Nopens, Ingmar

“…In this work, a mechanistic fluidized bed drying model computing the granule moisture content in function of granule size, drying time, process settings and…”
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Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability by Peeters, Michiel, Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Stauffer, Fanny, Arnfast, Lærke, Vigh, Tamas, Nopens, Ingmar, De Beer, Thomas

“…[Display omitted] Twin-screw wet granulation (TSWG) stands out as a promising continuous alternative to conventional batch fluid bed- and high shear wet…”
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Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation by Peeters, Michiel, Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Ghijs, Michael, Dos Santos Schultz, Eduardo, Roudgar, Mina, Vigh, Tamas, Stauffer, Fanny, Nopens, Ingmar, De Beer, Thomas

“…In the last few years, twin-screw wet granulation (TSWG) has become one of the key continuous pharmaceutical unit operations. Despite the many studies that…”
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Model-Guided Development of a Semi-Continuous Drying Process by Grelier, Anthony, Zadravec, Matej, Remmelgas, Johan, Forgber, Thomas, Colacino, Franco, Pilcer, Gabrielle, Stauffer, Fanny, Hörmann-Kincses, Theresa

“…Introduction With an increased adoption of continuous manufacturing for pharmaceutical production, the ConsiGma® CTL25 wet granulation and tableting line has…”
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Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Ghijs, Michael, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, De Beer, Thomas, Nopens, Ingmar

“…Population balance models (PBMs) have been widely studied for the simulation of continuous twin-screw wet granulation. Due to the limited data availability and…”
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Current Approaches to Design Space Development and Regulatory Applications for Drug Products: Findings from the IQ Utilization of Design Space for Filings Working Group Survey by Miesle, James E., Osei-Yeboah, Frederick, Pauli-Bruns, Anette, Chen, Bei, Manceva, Slobodanka, Wade, Jonathan B., Yin, Shawn, Desai, Divyakant, Dirat, Olivier, Bhugra, Chandan, Stauffer, Fanny

“…Purpose The concept of a Design Space (DSp) was introduced in ICH Q8 as a tool within the quality-by-design (QbD) approach to pharmaceutical development with…”
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Predicting powder feedability: A workflow for assessing the risk of flow stagnation and defining the operating space for different powder-feeder combinations by Hörmann-Kincses, Theresa R., Beretta, Michela, Kruisz, Julia, Stauffer, Fanny, Birk, Gudrun, Piccione, Patrick M., Holman, James, Khinast, Johannes G.

“…[Display omitted] •Extensive material and feeder characterization for ten pharmaceutical powders and four different feeders.•First time introduction of feeder…”
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Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding by Stauffer, Fanny, Ryckaert, Alexander, Van Hauwermeiren, Daan, Funke, Adrian, Djuric, Dejan, Nopens, Ingmar, De Beer, Thomas

“…During the last decade, the pharmaceutical industry has shown a growing interest in continuous twin-screw granulation (TSG). Despite flourishing literature on…”
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Validation of model-based design of experiments for continuous wet granulation and drying by Matsunami, Kensaku, Vandeputte, Tuur, Barrera Jiménez, Ana Alejandra, Peeters, Michiel, Ghijs, Michael, Van Hauwermeiren, Daan, Stauffer, Fanny, dos Santos Schultz, Eduardo, Nopens, Ingmar, De Beer, Thomas

“…This paper presents an application case of model-based design of experiments for the continuous twin-screw wet granulation and fluid-bed drying sequence. The…”
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Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, dos Santos Schultz, Eduardo, Kumar, Ashish, De Beer, Thomas, Nopens, Ingmar

“…In the pharmaceutical industry, twin-screw wet granulation has become a realistic option for the continuous manufacturing of solid drug products. Towards the…”
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Control strategy definition for a drug product continuous wet granulation process: Industrial case study by Chavez, Pierre-François, Stauffer, Fanny, Eeckman, Frédéric, Bostijn, Nils, Didion, David, Schaefer, Cédric, Yang, Hong, El Aalamat, Yousef, Lories, Xavier, Warman, Martin, Mathieu, Benoit, Mantanus, Jérôme

“…[Display omitted] This paper describes the specific control strategy of the commercial manufacturing process of an immediate release tablet formulation based…”
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Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective by Hsiao, Wen-Kai, Hörmann, Theresa R., Toson, Peter, Paudel, Amrit, Ghiotti, Patrizia, Stauffer, Fanny, Bauer, Finn, Lakio, Satu, Behrend, Olaf, Maurer, Reto, Holman, James, Khinast, Johannes

“…•Continuous processing represents new challenges in pharmaceutical material science.•Critique of key process steps such as feeding on product quality has…”
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Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation by Barrera Jiménez, Ana Alejandra, Matsunami, Kensaku, Van Hauwermeiren, Daan, Peeters, Michiel, Stauffer, Fanny, dos Santos Schultz, Eduardo, Kumar, Ashish, De Beer, Thomas, Nopens, Ingmar

“…Population balance models (PBM) have been widely used to model the twin-screw wet granulation (TSWG) in the continuous manufacturing of solid dosage forms…”
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