Search Results - "Staufenbiel, Matthias"

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease by Busche, Marc Aurel, Chen, Xiaowei, Henning, Horst A, Reichwald, Julia, Staufenbiel, Matthias, Sakmann, Bert, Konnerth, Arthur

“…Alzheimer’s disease (AD) is characterized by a progressive dysfunction of central neurons. Recent experimental evidence indicates that in the cortex, in…”
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Innate immune memory in the brain shapes neurological disease hallmarks by Wendeln, Ann-Christin, Degenhardt, Karoline, Kaurani, Lalit, Gertig, Michael, Ulas, Thomas, Jain, Gaurav, Wagner, Jessica, Häsler, Lisa M., Wild, Katleen, Skodras, Angelos, Blank, Thomas, Staszewski, Ori, Datta, Moumita, Centeno, Tonatiuh Pena, Capece, Vincenzo, Islam, Md. Rezaul, Kerimoglu, Cemil, Staufenbiel, Matthias, Schultze, Joachim L., Beyer, Marc, Prinz, Marco, Jucker, Mathias, Fischer, André, Neher, Jonas J.

“…Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases by Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias

“…A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions…”
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Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease by Mirochnic, Sebastian, Wolf, Susanne, Staufenbiel, Matthias, Kempermann, Gerd

“…An active lifestyle is to some degree protective against Alzheimer's disease (AD), but the biological basis for this benefit is still far from clear. We…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease by Rasmussen, Jay, Mahler, Jasmin, Beschorner, Natalie, Kaeser, Stephan A., Häsler, Lisa M., Baumann, Frank, Nyström, Sofie, Portelius, Erik, Blennow, Kaj, Lashley, Tammaryn, Fox, Nick C., Sepulveda-Falla, Diego, Glatzel, Markus, Oblak, Adrian L., Ghetti, Bernardino, Nilsson, K. Peter R., Hammarström, Per, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias

“…The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes…”
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Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease by Busche, Marc Aurel, Eichhoff, Gerhard, Adelsberger, Helmuth, Abramowski, Dorothee, Wiederhold, Karl-Heinz, Haass, Christian, Staufenbiel, Matthias, Konnerth, Arthur, Garaschuk, Olga

“…The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested…”
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Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice by Koldamova, Radosveta, Staufenbiel, Matthias, Lefterov, Iliya

“…ABCA1 (ATP-binding cassette transporter A1) is a major regulator of cholesterol efflux and high density lipoprotein (HDL) metabolism. Mutations in human ABCA1…”
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Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease by He, Ping, Cheng, Xin, Staufenbiel, Matthias, Li, Rena, Shen, Yong

“…Thalidomide is a tumor necrosis factor alpha (TNFα) inhibitor which has been found to have abilities against tumor growth, angiogenesis and inflammation…”
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog by Sirko, Swetlana, Behrendt, Gwendolyn, Johansson, Pia Annette, Tripathi, Pratibha, Costa, Marcos Romualdo, Bek, Sarah, Heinrich, Christophe, Tiedt, Steffen, Colak, Dilek, Dichgans, Martin, Fischer, Isabel Rebekka, Plesnila, Nikolaus, Staufenbiel, Matthias, Haass, Christian, Snapyan, Marina, Saghatelyan, Armen, Tsai, Li-Huei, Fischer, André, Grobe, Kay, Dimou, Leda, Götz, Magdalena

“…As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these…”
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Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life by Uhlmann, Ruth E., Rother, Christine, Rasmussen, Jay, Schelle, Juliane, Bergmann, Carina, Ullrich Gavilanes, Emily M., Fritschi, Sarah K., Buehler, Anika, Baumann, Frank, Skodras, Angelos, Al-Shaana, Rawaa, Beschorner, Natalie, Ye, Lan, Kaeser, Stephan A., Obermüller, Ulrike, Christensen, Søren, Kartberg, Fredrik, Stavenhagen, Jeffrey B., Rahfeld, Jens-Ulrich, Cynis, Holger, Qian, Fang, Weinreb, Paul H., Bussiere, Thierry, Walker, Lary C., Staufenbiel, Matthias, Jucker, Mathias

“…Amyloid-β (Aβ) deposits are a relatively late consequence of Aβ aggregation in Alzheimer‘s disease. When pathogenic Aβ seeds begin to form, propagate and…”
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Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease by Meyer, Eric P, Ulmann-Schuler, Alexandra, Staufenbiel, Matthias, Krucker, Thomas

“…Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's…”
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An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease by Kizuka, Yasuhiko, Kitazume, Shinobu, Fujinawa, Reiko, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C, Nakano, Miyako, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro, Staufenbiel, Matthias, Hatsuta, Hiroyuki, Murayama, Shigeo, Manya, Hiroshi, Endo, Tamao, Taniguchi, Naoyuki

“…The β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1), an essential protease for the generation of amyloid‐β (Aβ) peptide, is a major drug target for…”
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Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study by Winblad, Bengt, Prof, Andreasen, Niels, MD, Minthon, Lennart, Prof, Floesser, Annette, MSc, Imbert, Georges, PhD, Dumortier, Thomas, MSc, Maguire, R Paul, PhD, Blennow, Kaj, MD, Lundmark, Joens, MD, Staufenbiel, Matthias, PhD, Orgogozo, Jean-Marc, Prof, Graf, Ana, MD

“…Summary Background Immunotherapy targeting the amyloid β (Aβ) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to…”
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Hypoxia Facilitates Alzheimer's Disease Pathogenesis by Up-Regulating BACE1 Gene Expression by Sun, Xiulian, He, Guiqiong, Qing, Hong, Zhou, Weihui, Dobie, Frederick, Cai, Fang, Staufenbiel, Matthias, Huang, L. Eric, Song, Weihong

“…The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A history of stroke was found to…”
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Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation by Eisele, Yvonne S, Bolmont, Tristan, Heikenwalder, Mathias, Langer, Franziska, Jacobson, Laura H, Yan, Zheng-Xin, Roth, Klaus, Aguzzi, Adriano, Staufenbiel, Matthias, Walker, Lary C, Jucker, Mathias

“…Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of Aβ…”
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Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta by Schonrock, Nicole, Ke, Yazi D, Humphreys, David, Staufenbiel, Matthias, Ittner, Lars M, Preiss, Thomas, Götz, Jürgen

“…Normal brain development and function depends on microRNA (miRNA) networks to fine tune the balance between the transcriptome and proteome of the cell. These…”
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Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography by Maeda, Jun, Ji, Bin, Irie, Toshiaki, Tomiyama, Takami, Maruyama, Masahiro, Okauchi, Takashi, Staufenbiel, Matthias, Iwata, Nobuhisa, Ono, Maiko, Saido, Takaomi C, Suzuki, Kazutoshi, Mori, Hiroshi, Higuchi, Makoto, Suhara, Tetsuya

“…We provide the first evidence for the capability of a high-resolution positron emission tomographic (PET) imaging system in quantitatively mapping amyloid…”
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Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease by Grienberger, Christine, Rochefort, Nathalie L., Adelsberger, Helmuth, Henning, Horst A., Hill, Daniel N., Reichwald, Julia, Staufenbiel, Matthias, Konnerth, Arthur

“…The accumulation of amyloid-β in the brain is an essential feature of Alzheimer's disease. However, the impact of amyloid-β-accumulation on neuronal…”
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