Search Results - "Staud, F."

Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters by Karbanova, S., Cerveny, L., Jiraskova, L., Karahoda, R., Ceckova, M., Ptackova, Z., Staud, F.

“…[Display omitted] Ribavirin is a broad-spectrum nucleoside-derived antiviral drug used in combination pharmacotherapy treatment of hepatitis C virus infection…”
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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
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Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine by Karbanova, S., Cerveny, L., Ceckova, M., Ptackova, Z., Jiraskova, L., Greenwood, S., Staud, F.

“…Zidovudine (AZT) and emtricitabine (FTC) are effective and well tolerated antiretroviral drugs, routinely used in the prevention of perinatal HIV transmission…”
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Examination of Glucocorticoid Receptor α-Mediated Transcriptional Regulation of P-glycoprotein, CYP3A4 , and CYP2C9 Genes in Placental Trophoblast Cell Lines by Pavek, P, Cerveny, L, Svecova, L, Brysch, M, Libra, A, Vrzal, R, Nachtigal, P, Staud, F, Ulrichova, J, Fendrich, Z, Dvorak, Z

“…Abstract The placental trophoblast at different stages of pregnancy contains some drug transporters and xenobiotic-metabolising enzymes, as well as…”
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Corticosterone Transfer and Metabolism in the Dually Perfused Rat Placenta: Effect of 11β-hydroxysteroid Dehydrogenase Type 2 by Staud, F., Mazancová, K., Mikšík, I., Pávek, P., Fendrich, Z., Pácha, J.

“…Although rat is the most widely used model of glucocorticoid programming of the fetus, the role of rat placental 11β-hydroxysteroid dehydrogenase type 2…”
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Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation by Vagnerová, K, Vacková, Z, Klusonová, P, Staud, F, Kopecký, M, Ergang, P, Miksík, I, Pácha, J

“…The objective of this study was to investigate the role of 11beta-hydroxysteroid dehydrogenases (11HSD1 and 11HSD2) in determining the fetal concentration of…”
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Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation by Staud, Frantisek, Nishikawa, Makiya, Takakura, Yoshinobu, Hashida, Mitsuru

“…The effect of molecular mass and surface density of galactose residues on hepatic uptake and subsequent biliary excretion of galactosylated proteins was…”
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Breast cancer resistance protein (BCRP/ABCG2) by Staud, Frantisek, Pavek, Petr

“…Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member of ABC drug efflux membrane transporters. It is a 655 amino acid…”
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Influence of P-glycoprotein on the transplacental passage of cyclosporine by Pávek, P, Fendrich, Z, Staud, F, Malákova, J, Brozmanová, H, Láznícek, M, Semecký, V, Grundmann, M, Palicka, V

“…The transfer kinetics of cyclosporine across the dually perfused rat placenta in the maternal to fetal direction and a possible involvement of P-glycoprotein…”
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Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat by Cygalova, Lenka, Ceckova, Martina, Pavek, Petr, Staud, Frantisek

“…Breast cancer resistance protein (BCRP/ABCG2) is an ABC family drug efflux transporter expressed in a number of physiological tissues including placenta. Here…”
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Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents by Cerveny, Lukas, Pavek, Petr, Malakova, Jana, Staud, Frantisek, Fendrich, Zdenek

“…Purpose: Recent studies have indicated constitutive expression of efflux transporter, breast cancer resistance protein (BCRP, ABCG2), in endothelial cells of…”
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EXPRESSION AND FUNCTIONAL ACTIVITY OF BREAST CANCER RESISTANCE PROTEIN (BCRP, ABCG2) TRANSPORTER IN THE HUMAN CHORIOCARCINOMA CELL LINE BEWO by Ceckova, Martina, Libra, Antonin, Pavek, Petr, Nachtigal, Petr, Brabec, Marianne, Fuchs, Renate, Staud, Frantisek

“…SUMMARY 1 Breast cancer resistance protein (BCRP, ABCG2) is a drug efflux transporter that is believed to affect the drug disposition of several drugs and…”
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Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP by Ceckova, Martina, Vackova, Zuzana, Radilova, Hana, Libra, Antonin, Buncek, Martin, Staud, Frantisek

“…ATP-binding drug efflux transporters decrease intracellular concentrations of cytotoxic drugs, causing multidrug resistance in cancer. In this study, we…”
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Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta by Sklenářová, H, Pávek, P, Šatı́nský, D, Solich, P, Karlı́ček, R, Štaud, F, Fendrich, Z

“…The sequential injection (SIA) technique was applied in pharmacokinetic studies of the transporter-mediated passage of a model substrate, rhodamine 123…”
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Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11b-hydroxysteroid dehydrogenase type 2 in the rat placenta by Vackova, Z, Vagnerova, K, Libra, A, Miksik, I, Pacha, J, Staud, F

“…Placental 11b-hydroxysteroid dehydrogenase type 2 (11b-HSD2) is the key enzyme which protects the fetus from overexposure to glucocorticoids (GCs) by their…”
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P-glycoprotein expression and distribution in the rat placenta during pregnancy by Novotna, Martina, Libra, Antonin, Kopecky, Martin, Pavek, Petr, Fendrich, Zdenek, Semecky, Vladimir, Staud, Frantisek

“…P-glycoprotein (P-gp) is a drug efflux transporter that limits the entry of various potentially toxic drugs and xenobiotics into the fetus and is thus…”
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Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123 by Pavek, Petr, Staud, Frantisek, Fendrich, Zdenek, Sklenarova, Hana, Libra, Antonin, Novotna, Martina, Kopecky, Martin, Nobilis, Milan, Semecky, Vladimir

“…Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat…”
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Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice by Nishikawa, Makiya, Tamada, Ayumi, Hyoudou, Kenji, Umeyama, Yukari, Takahashi, Yuki, Kobayashi, Yuki, Kumai, Hitomi, Ishida, Emi, Staud, Frantisek, Yabe, Yoshiyuki, Takakura, Yoshinobu, Yamashita, Fumiyoshi, Hashida, Mitsuru

“…Bovine liver catalase derivatives possessing diverse tissue distribution properties were synthesized, and their effects on hepatic metastasis of colon…”
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Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2 by Staud, F, Mazancová, K, Miksík, I, Pávek, P, Fendrich, Z, Pácha, J

“…Although rat is the most widely used model of glucocorticoid programming of the fetus, the role of rat placental 11beta-hydroxysteroid dehydrogenase type 2…”
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In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project by Bremer, Susanne, Brittebo, Eva, Dencker, Lennart, Knudsen, Lisbeth Ehlert, Mathisien, Line, Olovsson, Matts, Pazos, Patricia, Pellizzer, Cristian, Paulesu, Luana Ricci, Schaefer, Wolfgang, Schwarz, Michael, Staud, Frantisek, Stavreus-Evers, Anneli, Vähänkangas, Kirsi

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