Search Results - "Statnick, M A"

Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats by ROHNER-JEANRENAUD, F, CRAFT, L. S, CARO, J. F, BRIDWELL, J, SUTER, T. M, TINSLEY, F. C, SMILEY, D. L, BURKHART, D. R, STATNICK, M. A, HEIMAN, M. L, RAVUSSIN, E

“…Cocaine- and amphetamine-regulated transcript (CART) is expressed within hypothalamic nuclei implicated in the regulation of feeding behaviour. It is…”
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Localization of opioid receptor antagonist [ 3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites by Gackenheimer, S.L., Suter, T.M., Pintar, J.E., Quimby, S.J., Wheeler, W.J., Mitch, C.H., Gehlert, D.R., Statnick, M.A.

“…Agonist stimulation of opioid receptors increases feeding in rodents, while opioid antagonists inhibit food intake. The pan-opioid antagonist, LY255582,…”
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Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s) by STATNICK, M. A, DAILEY, J. W, JOBE, P. C, BROWNING, R. A

“…The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have…”
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Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites by Statnick, Michael A, Schober, Douglas A, Gackenheimer, Susan, Johnson, Dwayne, Beavers, Lisa, Mayne, Nancy G, Burnett, J.Paul, Gadski, Robert, Gehlert, Donald R

“…Neuropeptide Y (NPY) is a 36-amino-acid peptide that appears to play a central role in the control of feeding behavior. Recently, a cDNA encoding a novel NPY…”
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Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats by Statnick, M A, Dailey, J W, Jobe, P C, Browning, R A

“…We characterized the nature of the deficit in brain serotonin (5-HT) exhibited by genetically epilepsy-prone rats (GEPR-9s) by regionally assessing three…”
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Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats by Statnick, M.A., Maring-Smith, M.L., Clough, R.W., Wang, C., Dailey, J.W., Jobe, P.C., Browning, R.A.

“…To further assess the role of 5-HT in the modulation of audiogenic seizures (AGS) in the Genetically Epilepsy-Prone Rat (GEPR), changes in AGS severity after…”
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Identification of multiple neuropeptide Y receptor subtypes in the human frontal cortex by Statnick, Michael A, Schober, Douglas A, Gehlert, Donald R

“…Recently, we found abundant mRNA and binding sites for neuropeptide Y Y 1-like receptors in the human cerebral cortex. However, an earlier study using indirect…”
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Cloning of a Human Receptor of the NPY Receptor Family with High Affinity for Pancreatic Polypeptide and Peptide YY by Lundell, I, Blomqvist, A G, Berglund, M M, Schober, D A, Johnson, D, Statnick, M A, Gadski, R A, Gehlert, D R, Larhammar, D

“…Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are structurally related peptides found in all higher vertebrates. NPY is expressed…”
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Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats by Rohner-Jeanrenaud, F, Craft, L S, Bridwell, J, Suter, T M, Tinsley, F C, Smiley, D L, Burkhart, DR, Statnick, MA, Heiman, M L, Ravussin, E, Caro, J F

“…Cocaine- and amphetamine-regulated transcript (CART) is expressed within hypothalamic nuclei implicated in the regulation of feeding behaviour. It is…”
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Effects of intraventricular locus coeruleus transplants on seizure severity in genetically epilepsy-prone rats following depletion of brain norepinephrine by Clough, R W, Browning, R A, Maring, M L, Statnick, M A, Wang, C, Jobe, P C

“…Audiogenic seizures (AGS) in genetically epilepsy-prone rats (GEPR) of the moderate-seizure substrain (GEPR-3s) were investigated to determine whether…”
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A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder by Statnick, Michael A, Chen, Yanyun, Ansonoff, Michael, Witkin, Jeffrey M, Rorick-Kehn, Linda, Suter, Todd M, Song, Min, Hu, Charlie, Lafuente, Celia, Jiménez, Alma, Benito, Ana, Diaz, Nuria, Martínez-Grau, Maria Angeles, Toledo, Miguel A, Pintar, John E

“…Nociceptin/orphanin FQ (N/OFQ), a 17 amino acid peptide, is the endogenous ligand of the ORL1/nociceptin-opioid-peptide (NOP) receptor. N/OFQ appears to…”
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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects by Raddad, Eyas, Chappell, Amy, Meyer, Jeffery, Wilson, Alan, Ruegg, Charles E, Tauscher, Johannes, Statnick, Michael A, Barth, Vanessa, Zhang, Xin, Verfaille, Steven J

“…Therapeutic benefits from nociceptin opioid peptide receptor (NOP) antagonism were proposed for obesity, eating disorders, and depression. LY2940094…”
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The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor by Lundell, I, Statnick, M A, Johnson, D, Schober, D A, Starbäck, P, Gehlert, D R, Larhammar, D

“…Pancreatic polypeptide (PP) is produced in the islets of Langerhans and released in response to meals. It belongs to a family of peptides that also includes…”
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The biology of Nociceptin/Orphanin FQ(N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence by WITKIN, Jeffrey M, STATNICK, Michael A, RORICK-KEHN, Linda M, PINTAR, John E, ANSONOFF, Michael, YANYUN CHEN, TUCKER, R. Craig, CICCOCIOPPO, Roberto

“…Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995. The generation of specific agonists, antagonists and receptor…”
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Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction by Kallupi, Marsida, Scuppa, Giulia, de Guglielmo, Giordano, Calò, Girolamo, Weiss, Friedbert, Statnick, Michael A, Rorick-Kehn, Linda M, Ciccocioppo, Roberto

“…The nociceptin (NOP) receptor is a G-protein-coupled receptor whose natural ligand is the NOP/orphanin FQ (N/OFQ) peptide. Evidence from pharmacological…”
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Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3‑c]pyran) Scaffold by Toledo, Miguel A, Pedregal, Concepción, Lafuente, Celia, Diaz, Nuria, Martinez-Grau, Maria Angeles, Jiménez, Alma, Benito, Ana, Torrado, Alicia, Mateos, Carlos, Joshi, Elizabeth M, Kahl, Steven D, Rash, Karen S, Mudra, Daniel R, Barth, Vanessa N, Shaw, David B, McKinzie, David, Witkin, Jeffrey M, Statnick, Michael A

“…Nociceptin/OFQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the ORL1/NOP receptor. Nociceptin appears to regulate a host of…”
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GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein by Tschöp, Matthias, Statnick, Michael A, Suter, Todd M, Heiman, Mark L

“…Ghrelin, an endogenous GH secretagogue, is capable of stimulating adiposity in rodents. Because such adiposity was thought to be mediated by hypothalamic NPY…”
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Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes by Statnick, M A, Beavers, L S, Conner, L J, Corominola, H, Johnson, D, Hammond, C D, Rafaeloff-Phail, R, Seng, T, Suter, T M, Sluka, J P, Ravussin, E, Gadski, R A, Caro, J F

“…We have screened a subtracted cDNA library in order to identify differentially expressed genes in omental adipose tissue of human patients with Type 2…”
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Preclinical findings predicting efficacy and side‐effect profile of LY2940094, an antagonist of nociceptin receptors by Witkin, Jeffrey M., Rorick‐Kehn, Linda M., Benvenga, Mark J., Adams, Benjamin L., Gleason, Scott D., Knitowski, Karen M., Li, Xia, Chaney, Steven, Falcone, Julie F., Smith, Janice W., Foss, Julie, Lloyd, Kirsti, Catlow, John T., McKinzie, David L., Svensson, Kjell A., Barth, Vanessa N., Toledo, Miguel A., Diaz, Nuria, Lafuente, Celia, Jiménez, Alma, Benito, Alfonso, Pedregal, Conception, Martínez‐Grau, Maria A., Post, Anke, Ansonoff, Michael A., Pintar, John E., Statnick, Michael A.

“…Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide whose receptor is designated ORL1 or nociceptin receptor (NOP). We utilized a potent, selective, and…”
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The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction by Berglund, Magnus M, Schober, Douglas A, Statnick, Michael A, McDonald, Patricia H, Gehlert, Donald R

“…The neuropeptide Y (NPY) family peptides NPY, peptide YY (PYY), and pancreatic polypeptide (PP) bind to four G protein-coupled receptors (GPCRs): Y1, Y2, Y4,…”
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