Search Results - "Stasi, Kalliopi"
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Interim safety and efficacy of gene therapy for RLBP1-associated retinal dystrophy: a phase 1/2 trial
Published in Nature communications (10-09-2024)“…Gene therapy holds promise for treatment of inherited retinal dystrophies, a group of rare genetic disorders characterized by severe loss of vision. Here, we…”
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Optimal isolation and xeno-free culture conditions for limbal stem cell function
Published in Investigative ophthalmology & visual science (20-01-2014)“…To preserve limbal stem cell (LSC) function in vitro with xenobiotic-free culture conditions. Limbal epithelial cells were isolated from 139 donors using 15…”
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Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants
Published in Translational vision science & technology (17-11-2022)“…PurposeThis first-in-human (FIH) study evaluated the safety, tolerability, pharmacokinetics, and effect on corneal sensitivity of topical ocular SAF312 in…”
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Retinal Dystrophy Associated With RLBP1 Retinitis Pigmentosa: A Five-Year Prospective Natural History Study
Published in Investigative ophthalmology & visual science (26-10-2023)“…PurposeTo assess the progression in functional and structural measures over a five-year period in patients with retinal dystrophy caused by RLBP1 gene…”
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Complement Component 1Q (C1Q) Upregulation in Retina of Murine, Primate, and Human Glaucomatous Eyes
Published in Investigative ophthalmology & visual science (01-03-2006)Get full text
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Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) for Postoperative Pain After Photorefractive Keratectomy
Published in Translational vision science & technology (01-03-2023)“…Evaluation of safety and efficacy of topical ocular SAF312 (Libvatrep) in post-photorefractive keratectomy (PRK) pain. In this placebo (vehicle)-controlled,…”
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Patient-Reported Outcomes in RLBP1 Retinal Dystrophy: Longitudinal Assessment in a Prospective Natural History Study
Published in Translational vision science & technology (14-11-2024)“…To evaluate the performance of two non-disease-specific patient-reported outcome (PRO) instruments, the National Eye Institute Visual Function Questionnaire-25…”
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Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes
Published in Investigative ophthalmology & visual science (01-03-2006)“…Complement has been implicated in the pathogenesis of neurodegenerative diseases. The purpose of this study was to investigate whether complement activation is…”
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Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep)
Published in Translational vision science & technology (01-09-2023)“…PurposeTo evaluate the pharmacology and toxicology of SAF312, a transient receptor potential vanilloid 1 (TRPV1) antagonist. MethodsTRPV1 expression in human…”
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10
Tear osmolarity and dry eye symptoms in diabetics
Published in Clinical ophthalmology (Auckland, N.Z.) (01-01-2014)“…To assess the relationship between tear osmolarity and dry eye symptoms in patients with diabetes. Fifty patients with diabetes were enrolled. Demographic…”
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Update on phototherapeutic keratectomy
Published in Current opinion in ophthalmology (01-07-2009)“…PURPOSE OF REVIEWTo review all recent publications on the use of phototherapeutic keratectomy (PTK). RECENT FINDINGSRecent studies confirm the beneficial…”
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Ceruloplasmin Upregulation in Retina of Murine and Human Glaucomatous Eyes
Published in Investigative ophthalmology & visual science (01-02-2007)“…Ceruloplasmin (Cp) expression is increased locally as a response to many neurodegenerative conditions. The purposes of this study were to confirm findings of…”
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13
Genetically induced retinal degeneration leads to changes in metabotropic glutamate receptor expression
Published in Neuroscience letters (23-01-2006)“…In the retina, neurotransmission from photoreceptors to ON-cone and rod bipolar cells is sign reversing and mediated by the metabotropic glutamate receptor…”
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Retinal Arteriolar Spasm During Transient Monocular Visual Loss in Eosinophilic Vasculitis
Published in Journal of neuro-ophthalmology (01-03-2009)“…A patient with eosinophilic vasculitis and acquired immunodeficiency syndrome (AIDS) developed episodic transient monocular visual loss. During or immediately…”
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Benzodiazepine and kainate receptor binding sites in the RCS rat retina
Published in Graefe's archive for clinical and experimental ophthalmology (01-02-2003)“…The effect of age and photoreceptor degeneration on the kainate subtype of glutamate receptors and on the benzodiazepine-sensitive gamma-aminobutyric acid-A…”
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Photodynamic treatment in a rabbit model of glaucoma surgery
Published in Acta ophthalmologica Scandinavica (01-10-2006)“… Purpose: To evaluate the safety and efficacy of postoperative verteporfin photodynamic treatment as an adjunct to glaucoma experimental filtration surgery…”
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