Search Results - "Staron, Matthew M."

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection by Staron, Matthew M., Gray, Simon M., Marshall, Heather D., Parish, Ian A., Chen, Jonathan H., Perry, Curtis J., Cui, Guoliang, Li, Ming O., Kaech, Susan M.

“…Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation,…”
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Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells by Ray, John P., Marshall, Heather D., Laidlaw, Brian J., Staron, Matthew M., Kaech, Susan M., Craft, Joe

“…Follicular helper T (Tfh) cells are required for the establishment of T-dependent B cell memory and high affinity antibody-secreting cells. We have revealed…”
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IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity by Cui, Guoliang, Staron, Matthew M., Gray, Simon M., Ho, Ping-Chih, Amezquita, Robert A., Wu, Jingxia, Kaech, Susan M.

“…Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory…”
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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells by Ray, John P., Staron, Matthew M., Shyer, Justin A., Ho, Ping-Chih, Marshall, Heather D., Gray, Simon M., Laidlaw, Brian J., Araki, Koichi, Ahmed, Rafi, Kaech, Susan M., Craft, Joe

“…The differentiation of CD4+ helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic…”
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Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection by Chen, Jonathan H, Perry, Curtis J, Tsui, Yao-Chen, Staron, Matthew M, Parish, Ian A, Dominguez, Claudia X, Rosenberg, Daniel W, Kaech, Susan M

“…Susan Kaech and colleagues report that in chronic viral infection, prostaglandin E2 and PD-1 signaling suppressed the function and survival of cytotoxic T…”
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A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression by Myers, Lara M., Tal, Michal Caspi, Torrez Dulgeroff, Laughing Bear, Carmody, Aaron B., Messer, Ronald J., Gulati, Gunsagar, Yiu, Ying Ying, Staron, Matthew M., Angel, Cesar Lopez, Sinha, Rahul, Markovic, Maxim, Pham, Edward A., Fram, Benjamin, Ahmed, Aijaz, Newman, Aaron M., Glenn, Jeffrey S., Davis, Mark M., Kaech, Susan M., Weissman, Irving L., Hasenkrug, Kim J.

“…Prolonged exposure of CD8 + T cells to antigenic stimulation, as in chronic viral infections, leads to a state of diminished function termed exhaustion. We now…”
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Multi-Omics Characterization of Colon Mucosa and Submucosa/Wall from Crohn's Disease Patients by Jin, Liang, Macoritto, Michael, Wang, Jing, Bi, Yingtao, Wang, Fei, Suarez-Fueyo, Abel, Paez-Cortez, Jesus, Hu, Chenqi, Knight, Heather, Mascanfroni, Ivan, Staron, Matthew M, Schwartz Sterman, Annette, Houghton, Jean Marie, Westmoreland, Susan, Tian, Yu

“…Crohn's disease (CD) is a subtype of inflammatory bowel disease (IBD) characterized by transmural disease. The concept of transmural healing (TH) has been…”
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The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa by Marshall, Heather D, Ray, John P, Laidlaw, Brian J, Zhang, Nianzhi, Gawande, Dipika, Staron, Matthew M, Craft, Joe, Kaech, Susan M

“…T follicular helper cells (Tfh) are crucial for the initiation and maintenance of germinal center (GC) reactions and high affinity, isotype-switched antibody…”
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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig by Bardwell, Philip D., Staron, Matthew M., Liu, Junjian, Tao, Qingfeng, Scesney, Susanne, Bukofzer, Gail, Rodriguez, Luis E., Choi, Chee-Ho, Wang, Jennifer, Chang, Qing, Dong, Feng, Donawho, Cherrie, Wang, Jieyi, Grinnell, Christine M., Tarcsa, Edit, Hutchins, Charles, Ghayur, Tariq, Gu, Jijie

“…Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However,…”
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The interface between transcriptional and epigenetic control of effector and memory CD8+ T-cell differentiation by Gray, Simon M., Kaech, Susan M., Staron, Matthew M.

“…Summary Immunity to many intracellular pathogens requires the proliferation, differentiation, and function of CD8+ cytotoxic T lymphocytes (CTLs). While the…”
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Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 by Parish, Ian A, Marshall, Heather D, Staron, Matthew M, Lang, Philipp A, Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Tsui, Yao-Chen, Perry, Curtis, Laidlaw, Brian J, Ohashi, Pamela S, Weaver, Casey T, Kaech, Susan M

“…During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host…”
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Correction: The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa by Marshall, Heather D, Ray, John P, Laidlaw, Brian J, Zhang, Nianzhi, Gawande, Dipika, Staron, Matthew M, Craft, Joe, Kaech, Susan M

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The interface between transcriptional and epigenetic control of effector and memory CD 8 + T‐cell differentiation by Gray, Simon M., Kaech, Susan M., Staron, Matthew M.

“…Summary Immunity to many intracellular pathogens requires the proliferation, differentiation, and function of CD 8 + cytotoxic T lymphocytes ( CTL s). While…”
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The Transcription Factor STAT3 and Type I Interferons Are Mutually Repressive Insulators for Differentiation of Follicular Helper and T Helper_1 Cells by Ray, John P., Marshall, Heather D., Laidlaw, Brian J., Staron, Matthew M., Kaech, Susan M., Craft, Joe

“…Follicular helper T (Tfh) cells are required for the establishment of T-dependent B cell memory and high affinity antibody-secreting cells. We have revealed…”
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The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells by Ray, John P., Staron, Matthew M., Shyer, Justin A., Ho, Ping-Chih, Marshall, Heather D., Gray, Simon M., Laidlaw, Brian J., Araki, Koichi, Ahmed, Rafi, Kaech, Susan M., Craft, Joe

“…The differentiation of CD4 + helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic…”
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A critical role for gp96 in lymphopoiesis, thrombopoiesis, and intestinal homeostasis by Staron, Matthew M

“…gp96 is an endoplasmic reticulum chaperone for multiple Toll-like receptors and integrins. Our lab has generated a conditional gp96 knockout model allowing…”
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A critical role for gp96 in lymphopoiesis, thrombopoiesis, and intestinal homeostasis by Staron, Matthew M

“…gp96 is an endoplasmic reticulum chaperone for multiple Toll-like receptors and integrins. Our lab has generated a conditional gp96 knockout model allowing…”
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