Search Results - "Starkus, John G"

The calcium‐permeable non‐selective cation channel TRPM2 is modulated by cellular acidification by Starkus, John G., Fleig, Andrea, Penner, Reinhold

“…TRPM2 is a calcium‐permeable non‐selective cation channel expressed in the plasma membrane and in lysosomes that is critically involved in aggravating reactive…”
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Ion conduction through C-type inactivated Shaker channels by Starkus, J G, Kuschel, L, Rayner, M D, Heinemann, S H

“…C-type inactivation of Shaker potassium channels involves entry into a state (or states) in which the inactivated channels appear nonconducting in…”
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Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels by Starkus, John G, Poerzgen, Peter, Layugan, Kristine, Kawabata, Kelly Galbraith, Goto, Jun-Ichi, Suzuki, Sayuri, Myers, George, Kelly, Michelle, Penner, Reinhold, Fleig, Andrea, Horgen, F. David

“…TRPM2 is a Ca2+-permeable, nonselective cation channel that plays a role in oxidant-induced cell death, insulin secretion, and cytokine release. Few TRPM2…”
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The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism by Gessner, Guido, Macianskiene, Regina, Starkus, John G., Schönherr, Roland, Heinemann, Stefan H.

“…Human ether à go-go related gene (hERG1) potassium channels underlie the repolarizing I Kr current in the heart. Since they are targets of various drugs with…”
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Acidic Cannabinoids Suppress Proinflammatory Cytokine Release by Blocking Store-operated Calcium Entry by Faouzi, Malika, Wakano, Clay, Monteilh-Zoller, Mahealani K, Neupane, Ram P, Starkus, John G, Neupane, Jayanti Bhandari, Cullen, Aaron J, Johnson, Brandon E, Fleig, Andrea, Penner, Reinhold

“…has long been known to affect numerous biological activities. Although plant extracts, purified cannabinoids, or synthetic cannabinoid analogs have shown…”
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pH-dependent modulation of Kv1.3 inactivation: role of His399 by Somodi, Sándor, Varga, Zoltán, Hajdu, Péter, Starkus, John G, Levy, Daniel I, Gáspár, Rezso, Panyi, György

“…The Kv1.3 K(+) channel lacks N-type inactivation, but during prolonged depolarized periods it inactivates via the slow (P/C type) mechanism. It bears a…”
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Mechanisms of the inhibition of Shaker potassium channels by protons by Starkus, John G, Varga, Zoltan, Schönherr, Roland, Heinemann, Stefan H

“…Potassium channels are regulated by protons in various ways and, in most cases, acidification results in potassium current reduction. To elucidate the…”
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Cations affect the rate of gating charge recovery in wild-type and W434F Shaker channels through a variety of mechanisms by Varga, Zoltan, Rayner, Martin D, Starkus, John G

“…In this study we examine the effects of ionic conditions on the gating charge movement in the fast inactivation-removed wild-type Shaker channel and its W434F…”
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Macroscopic Na+ currents in the "Nonconducting" Shaker potassium channel mutant W434F by Starkus, J G, Kuschel, L, Rayner, M D, Heinemann, S H

“…C-type inactivation in Shaker potassium channels inhibits K+ permeation. The associated structural changes appear to involve the outer region of the pore…”
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Voltage dependence of slow inactivation in Shaker potassium channels results from changes in relative K(+) and Na(+) permeabilities by Starkus, J G, Heinemann, S H, Rayner, M D

“…Time constants of slow inactivation were investigated in NH(2)-terminal deleted Shaker potassium channels using macro-patch recordings from Xenopus oocytes…”
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Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels by Bao, H, Hakeem, A, Henteleff, M, Starkus, J G, Rayner, M D

“…Shaker channel mutants, in which the first (R362), second (R365), and fourth (R371) basic residues in the S4 segment have been neutralized, are found to pass…”
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Effects of clamp rise-time on rat brain IIA sodium channels in Xenopus oocytes by Ruben, Peter C., Fleig, Andrea, Featherstone, David, Starkus, John G., Rayner, Martin D.

“…The kinetic properties of wild-type rat brain IIa sodium channels in excised macropatches were studied using step depolarizations and ramp depolarizations to…”
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Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches by FLEIG, A, FITCH, J. M, GOLDIN, A. L, RAYNER, M. D, STARKUS, J. G, RUBEN, P. C

“…Macroscopic currents of wild-type rat brain IIA (RBIIA) and mutant Na channels were recorded in excised patches from Xenopus oocytes. A charge deletion (K859Q)…”
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