Search Results - "Stark, Wilhelm"

Total Hip Replacement Versus Open Reduction and Internal Fixation of Displaced Femoral Neck Fractures: A Randomized Long-Term Follow-up Study by Chammout, Ghazi Khalil, Mukka, Sebastian Simon, Carlsson, Thomas, Neander, Gustaf Fredrik, Helge Stark, André Wilhelm, Sköldenberg, Olof Gustaf

“…Clinical trials with short and intermediate-term follow-up have demonstrated superior results for total hip replacement as compared with internal fixation with…”
Get full text

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes by Wagner, Jürgen, von Matt, Peter, Sedrani, Richard, Albert, Rainer, Cooke, Nigel, Ehrhardt, Claus, Geiser, Martin, Rummel, Gabriele, Stark, Wilhelm, Strauss, Andre, Cowan-Jacob, Sandra W, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was found to be a potent,…”
Get full text

Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis by Manley, Paul William, Bold, Guido, Brüggen, Josef, Fendrich, Gabrielle, Furet, Pascal, Mestan, Jürgen, Schnell, Christian, Stolz, Barbara, Meyer, Thomas, Meyhack, Bernd, Stark, Wilhelm, Strauss, Andre, Wood, Jeanette

“…Initial studies with angiogenesis inhibitors showed little clinical benefit. However, recently reported clinical studies in colorectal cancer have shown that…”
Get full text

The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations by Leder, Lukas, Stark, Wilhelm, Freuler, Felix, Marsh, May, Meyerhofer, Marco, Stettler, Thomas, Mayr, Lorenz M, Britanova, Olga V, Strukova, Lydia A, Chudakov, Dmitriy M, Souslova, Ekaterina A

“…Here we report the first crystal structure of a high-contrast genetically encoded circularly permuted green fluorescent protein (cpGFP)-based Ca(2+) sensor,…”
Get full text

Needle Finder: a search engine for retrieving and evaluating hidden structural features and much more by Stark, Wilhelm, Putrino, Nunzio, Rüegg, Karin, Drozd, Manfred, Brodbeck, Dominique, Degen, Markus

“…Abstract only…”
Get full text

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes by van Eis, Maurice J., Evenou, Jean-Pierre, Floersheim, Philipp, Gaul, Christoph, Cowan-Jacob, Sandra W., Monovich, Lauren, Rummel, Gabriele, Schuler, Walter, Stark, Wilhelm, Strauss, Andre, Matt, Anette von, Vangrevelinghe, Eric, Wagner, Juergen, Soldermann, Nicolas

“…Compound 11 potently inhibits the novel PKC isozymes δ, ε, η, θ, with IC 50 values of 20, 5, 5 and 77 nM, respectively, and displays a 11–180-fold selectivity…”
Get full text

The structure of neutral protease from Bacillus cereus at 0.2‐nm resolution by STARK, Wilhelm, PAUPTIT, Richard A., WILSON, Keith S., JANSONIUS, Johan N.

“…The crystal structure of the neutral protease from Bacillus cereus has been refined to an R factor of 17.5% at 0.2‐nm resolution. The enzyme, an extracellular…”
Get full text

Estrogen Receptor Modulators:  Identification and Structure−Activity Relationships of Potent ERα-Selective Tetrahydroisoquinoline Ligands by Renaud, Johanne, Bischoff, Serge François, Buhl, Thomas, Floersheim, Philipp, Fournier, Brigitte, Halleux, Christine, Kallen, Joerg, Keller, Hansjoerg, Schlaeppi, Jean-Marc, Stark, Wilhelm

“…As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), tetrahydroisoquinoline derivative 27 was discovered by high…”
Get full text

Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase by Cowan-Jacob, Sandra W., Kaufmann, Markus, Anselmo, Anthony N., Stark, Wilhelm, Grütter, Markus G.

“…The crystal structure of the tetrameric form of d‐glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) isolated from rabbit muscle was solved at 2.4 Å resolution…”
Get full text

A New Class of HIV-1 Tat Antagonist Acting through Tat−TAR Inhibition by Hamy, François, Brondani, Vincent, Flörsheimer, Andreas, Stark, Wilhelm, Blommers, Marcel J. J, Klimkait, Thomas

“…The main transcriptional regulator of the human immunodeficiency virus, the Tat protein, recognizes and binds to a small structured RNA element at the 5‘ end…”
Get full text

Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate by Hester, G, Stark, W, Moser, M, Kallen, J, Marković-Housley, Z, Jansonius, J N

“…Phosphoserine aminotransferase (PSAT; EC 2.6.1.52), a member of subgroup IV of the aminotransferases, catalyses the conversion of 3-phosphohydroxypyruvate to…”
Get full text

Transferred Cross-Correlated Relaxation Complements Transferred NOE:  Structure of an IL-4R-Derived Peptide Bound to STAT-6 by Blommers, Marcel J. J, Stark, Wilhelm, Jones, Carol E, Head, Denis, Owen, Charles E, Jahnke, Wolfgang

“…A new NMR method is proposed which enables the measurement of projection angles in the bound conformation of a weakly binding ligand complexed to its receptor…”
Get full text

Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands by Renaud, Johanne, Bischoff, Serge François, Buhl, Thomas, Floersheim, Philipp, Fournier, Brigitte, Halleux, Christine, Kallen, Joerg, Keller, Hansjoerg, Schlaeppi, Jean-Marc, Stark, Wilhelm

“…As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), tetrahydroisoquinoline derivative 27 was discovered by high…”
Get full text

Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 Å resolution: comparison of the unligated enzyme and a complex with α-methyl- l -glutamate 1 1Edited by R. Huber by Hester, Gerko, Stark, Wilhelm, Moser, Markus, Kallen, Jörg, Marković-Housley, Zora, Jansonius, Johan N.

Get full text

Total Hip Replacement Versus Open Reduction and Internal Fixation of Displaced Femoral Neck Fractures by Chammout, Ghazi Khalil, MD, Carlsson, Thomas, MD, Neander, Gustaf Fredrik, MD, PhD, Helge Stark, André Wilhelm, MD, PhD, Sköldenberg, Olof Gustaf, MD, PhD, Mukka, Sebastian Simon, MD

“…Background Clinical trials with short and intermediate-term follow-up have demonstrated superior results for total hip replacement as compared with internal…”
Get full text

Membrane-Mediated Assembly of Filamentous Bacteriophage Pf1 Coat Protein by Nambudripad, Raman, Stark, Wilhelm, Opella, Stanley J., Makowski, Lee

“…Filamentous bacteriophage Pf1 assembles by a membrane-mediated process during which the viral DNA is secreted through the membrane while being encapsulated by…”
Get full text

Neutron diffraction studies of the structure of filamentous bacteriophage Pf1. Demonstration that the coat protein consists of a pair of alpha-helices with an intervening, non-helical surface loop by Nambudripad, R, Stark, W, Makowski, L

“…The structure of filamentous bacteriophage Pf1 has been studied using neutron diffraction from magnetically oriented gels of native and specifically deuterated…”
Get more information

Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis by Manley, Paul William, Bold, Guido, Brüggen, Josef, Fendrich, Gabrielle, Furet, Pascal, Mestan, Jürgen, Schnell, Christian, Stolz, Barbara, Meyer, Thomas, Meyhack, Bernd, Stark, Wilhelm, Strauss, Andre, Wood, Jeanette

“…Initial studies with angiogenesis inhibitors showed little clinical benefit. However, recently reported clinical studies in colorectal cancer have shown that…”
Get more information

Identification of Manα1‐3Manα1‐2Man and Man‐linked phosphate on O‐mannosylated recombinant leech‐derived tryptase inhibitor produced by Saccharomyces cerevisiae and determination of the solution conformation of the mannosylated polypeptide by Bergwerff, Aldert A., Stark, Wilhelm, Fendrich, Gabriele, Knecht, René, Blommers, Marcel J. J., Maerki, Walter, Kragten, Eddy A., van Oostrum, Jan

“…The production of recombinant leech‐derived tryptase inhibitor (rLDTI) by two different strains of Saccharomyces cerevisiae resulted in the secretion of…”
Get full text

Sparse matrix algorithms applied to dem generation by Stark, Wilhelm, Steidler, Franz

Get full text