Search Results - "Stark, Klaus J."

Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study by Brandl, Caroline, Brücklmayer, Christiane, Günther, Felix, Zimmermann, Martina E, Küchenhoff, Helmut, Helbig, Horst, Weber, Bernhard H F, Heid, Iris M, Stark, Klaus J

“…To systematically analyze thicknesses of retinal layers in an older population and their link to early age-related macular degeneration (AMD). In the AugUR…”
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KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies by Stanzick, Kira J, Stark, Klaus J, Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M, Winkler, Thomas W

“…Abstract Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these…”
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Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood by Koller, Adriana, Lamina, Claudia, Brandl, Caroline, Zimmermann, Martina E., Stark, Klaus J., Weissensteiner, Hansi, Würzner, Reinhard, Heid, Iris M., Kronenberg, Florian

“…Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased…”
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DNA extraction from clotted blood in genotyping quality by Stanzick, Kira J, Simon, Josef, Zimmermann, Martina E, Schachtner, Michael, Peterhoff, David, Niller, Hans-Helmut, Überla, Klaus, Wagner, Ralf, Heid, Iris M, Stark, Klaus J

“…DNA extraction from frozen blood clots is challenging. Here, the authors applied QIAGEN Clotspin Baskets and the Gentra Puregene Blood Kit for DNA extraction…”
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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease by Winkler, Thomas W, Grassmann, Felix, Brandl, Caroline, Kiel, Christina, Günther, Felix, Strunz, Tobias, Weidner, Lorraine, Zimmermann, Martina E, Korb, Christina A, Poplawski, Alicia, Schuster, Alexander K, Müller-Nurasyid, Martina, Peters, Annette, Rauscher, Franziska G, Elze, Tobias, Horn, Katrin, Scholz, Markus, Cañadas-Garre, Marisa, McKnight, Amy Jayne, Quinn, Nicola, Hogg, Ruth E, Küchenhoff, Helmut, Heid, Iris M, Stark, Klaus J, Weber, Bernhard H F

“…Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been…”
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Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number by Koller, Adriana, Filosi, Michele, Weissensteiner, Hansi, Fazzini, Federica, Gorski, Mathias, Pattaro, Cristian, Schönherr, Sebastian, Forer, Lukas, Herold, Janina M., Stark, Klaus J., Döttelmayer, Patricia, Hicks, Andrew A., Pramstaller, Peter P., Würzner, Reinhard, Eckardt, Kai-Uwe, Heid, Iris M., Fuchsberger, Christian, Lamina, Claudia, Kronenberg, Florian

“…Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association…”
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Changes in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study by Brandl, Caroline, Zimmermann, Martina E, Günther, Felix, Dietl, Alexander, Küchenhoff, Helmut, Loss, Julika, Stark, Klaus J, Heid, Iris M

“…Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these…”
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Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study by Brandl, Caroline, Breinlich, Valentin, Stark, Klaus J, Enzinger, Sabrina, Aßenmacher, Matthias, Olden, Matthias, Grassmann, Felix, Graw, Jochen, Heier, Margit, Peters, Annette, Helbig, Horst, Küchenhoff, Helmut, Weber, Bernhard H F, Heid, Iris M

“…Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50…”
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Distribution and specificity of high-sensitivity cardiac troponin T in older adults without acute cardiac conditions: cross-sectional results from the population-based AugUR study by Dietl, Alexander, Zimmermann, Martina E, Brandl, Caroline, Wallner, Stefan, Burkhardt, Ralph, Maier, Lars S, Luchner, Andreas, Heid, Iris M, Stark, Klaus J

“…ObjectiveEuropean guidelines recommended a uniform upper reference limit of high-sensitivity cardiac troponin T (hsTnT) to rule out non-ST segment elevation…”
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Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020 by Wagner, Ralf, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Berr, Melanie, Einhauser, Sebastian, Schütz, Anja, Niller, Hans Helmut, Steininger, Philipp, Knöll, Antje, Tenbusch, Matthias, Maier, Clara, Korn, Klaus, Stark, Klaus J., Gessner, André, Burkhardt, Ralph, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B., Heid, Iris M., Gefeller, Olaf, Überla, Klaus

“…SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth…”
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Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany by Einhauser, Sebastian, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Niller, Hans-Helmut, Steininger, Philipp, Knöll, Antje, Korn, Klaus, Berr, Melanie, Schütz, Anja, Wiegrebe, Simon, Stark, Klaus J, Gessner, André, Burkhardt, Ralph, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B, Heid, Iris M, Gefeller, Olaf, Überla, Klaus, Wagner, Ralf

“…Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which…”
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Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study by Herold, Janina M, Nano, Jana, Gorski, Mathias, Winkler, Thomas W, Stanzick, Kira J, Zimmermann, Martina E, Brandl, Caroline, Peters, Annette, Koenig, Wolfgang, Burkhardt, Ralph, Gessner, André, Heid, Iris M, Gieger, Christian, Stark, Klaus J

“…Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFR ) have been applied…”
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Incidence, progression and risk factors of age-related macular degeneration in 35–95-year-old individuals from three jointly designed German cohort studies by Brandl, Caroline, Günther, Felix, Zimmermann, Martina E, Hartmann, Kathrin I, Eberlein, Gregor, Barth, Teresa, Winkler, Thomas W, Linkohr, Birgit, Heier, Margit, Peters, Annette, Li, Jeany Q, Finger, Robert P, Helbig, Horst, Weber, Bernhard H F, Küchenhoff, Helmut, Mueller, Arthur, Stark, Klaus J, Heid, Iris M

“…ObjectiveTo estimate age-related macular degeneration (AMD) incidence/progression across a wide age range.Methods and analysisAMD at baseline and follow-up…”
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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Stanzick, Kira J., Li, Yong, Schlosser, Pascal, Gorski, Mathias, Wuttke, Matthias, Thomas, Laurent F., Rasheed, Humaira, Rowan, Bryce X., Graham, Sarah E., Vanderweff, Brett R., Patil, Snehal B., Robinson-Cohen, Cassiane, Gaziano, John M., O’Donnell, Christopher J., Willer, Cristen J., Hallan, Stein, Åsvold, Bjørn Olav, Gessner, Andre, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna, Stark, Klaus J., Heid, Iris M., Winkler, Thomas W.

“…Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing…”
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Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women by Koller, Adriana, Brandl, Caroline, Lamina, Claudia, Zimmermann, Martina E, Summerer, Monika, Stark, Klaus J, Würzner, Reinhard, Heid, Iris M, Kronenberg, Florian

“…Relative telomere length (RTL) is a biomarker for physiological aging. Premature shortening of telomeres is associated with oxidative stress, which is one…”
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Population-based reference values for kidney function and kidney function decline in 25- to 95-year-old Germans without and with diabetes by Herold, Janina M, Wiegrebe, Simon, Nano, Jana, Jung, Bettina, Gorski, Mathias, Thorand, Barbara, Koenig, Wolfgang, Zeller, Tanja, Zimmermann, Martina E, Burkhardt, Ralph, Banas, Bernhard, Küchenhoff, Helmut, Stark, Klaus J, Peters, Annette, Böger, Carsten A, Heid, Iris M

“…Understanding normal aging of kidney function is pivotal to help distinguish individuals at particular risk for chronic kidney disease. Glomerular filtration…”
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Genetic Risk Score Analysis Supports a Joint View of Two Classification Systems for Age-Related Macular Degeneration by Herold, Janina M., Zimmermann, Martina E., Gorski, Mathias, Günther, Felix, Weber, Bernhard H. F., Helbig, Horst, Stark, Klaus J., Heid, Iris M., Brandl, Caroline

“…PurposeThe purpose of this study was to evaluate the utility of combining the Clinical Classification (CC) and the Three Continent age-related macular…”
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Frequency of hand eczema in the elderly: Cross‐sectional findings from the German AugUR study by Drewitz, Karl Philipp, Stark, Klaus J., Zimmermann, Martina E., Heid, Iris M., Apfelbacher, Christian J.

“…Background Hand eczema (HE) is a chronic inflammatory skin disease caused by a genetic predisposition and environmental exposures. There is a lack of…”
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On the impact of different approaches to classify age-related macular degeneration: Results from the German AugUR study by Brandl, Caroline, Zimmermann, Martina E., Günther, Felix, Barth, Teresa, Olden, Matthias, Schelter, Sabine C., Kronenberg, Florian, Loss, Julika, Küchenhoff, Helmut, Helbig, Horst, Weber, Bernhard H. F., Stark, Klaus J., Heid, Iris M.

“…While age-related macular degeneration (AMD) poses an important personal and public health burden, comparing epidemiological studies on AMD is hampered by…”
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Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study by Mauschitz, Matthias M., Schmitz, Marie-Therese, Verzijden, Timo, Schmid, Matthias, Thee, Eric F., Colijn, Johanna M., Delcourt, Cécile, Cougnard-Grégoire, Audrey, Merle, Bénédicte M.J., Korobelnik, Jean-François, Gopinath, Bamini, Mitchell, Paul, Elbaz, Hisham, Schuster, Alexander K., Wild, Philipp S., Brandl, Caroline, Stark, Klaus J., Heid, Iris M., Günther, Felix, Peters, Annette, Klaver, Caroline C.W., Finger, Robert P.

“…To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population…”
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