Search Results - "Stark, Kimberly L"

Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia by Gogos, Joseph A, Gordon, Joshua A, Sigurdsson, Torfi, Stark, Kimberly L, Karayiorgou, Maria

“…Abnormalities in functional connectivity between brain areas have been postulated as an important pathophysiological mechanism underlying schizophrenia. In…”
Get full text

Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion by Xu, Bin, Hsu, Pei-Ken, Stark, Kimberly L., Karayiorgou, Maria, Gogos, Joseph A.

“…22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A+/− mice, which model this microdeletion, revealed…”
Get full text

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

“…is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice…”
Get full text

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma by Reese, Rebecca M., Dourado, Michelle, Anderson, Keith, Warming, Søren, Stark, Kimberly L., Balestrini, Alessia, Suto, Eric, Lee, Wyne, Riol-Blanco, Lorena, Shields, Shannon D., Hackos, David H.

“…The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP…”
Get full text

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease by Brendza, Robert, Gao, Xiaoying, Stark, Kimberly L., Lin, Han, Lee, Seung-Hye, Hu, Changyun, Cai, Hao, DiCara, Danielle, Hsiao, Yi-Chun, Ngu, Hai, Foreman, Oded, Baca, Miriam, Dohse, Monika, Fortin, Jean-Phillipe, Corpuz, Racquel, Seshasayee, Dhaya, Easton, Amy, Ayalon, Gai, Hötzel, Isidro, Chih, Ben

“…Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition…”
Get full text

The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion by Fénelon, Karine, Xu, Bin, Lai, Cora S, Mukai, Jun, Markx, Sander, Stark, Kimberly L, Hsu, Pei-Ken, Gan, Wen-Biao, Fischbach, Gerald D, MacDermott, Amy B, Karayiorgou, Maria, Gogos, Joseph A

“…We used a mouse model of the schizophrenia-predisposing 22q11.2 microdeletion to evaluate how this genetic lesion affects cortical neural circuits at the…”
Get full text

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion by Drew, Liam J., Stark, Kimberly L., Fénelon, Karine, Karayiorgou, Maria, MacDermott, Amy B., Gogos, Joseph A.

“…22q11.2 chromosomal deletions are recurrent copy number mutations that increase the risk of schizophrenia around thirty-fold. Deletion of the orthologous…”
Get full text

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology by Lee, Seung-Hye, Meilandt, William J., Xie, Luke, Gandham, Vineela D., Ngu, Hai, Barck, Kai H., Rezzonico, Mitchell G., Imperio, Jose, Lalehzadeh, Guita, Huntley, Melanie A., Stark, Kimberly L., Foreman, Oded, Carano, Richard A.D., Friedman, Brad A., Sheng, Morgan, Easton, Amy, Bohlen, Christopher J., Hansen, David V.

“…Loss-of-function TREM2 mutations strongly increase Alzheimer’s disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models…”
Get full text

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model by Mills, Alea A, Gogos, Joseph A, Lai, Wen-Sung, Xu, Bin, Liu, Hui, Karayiorgou, Maria, Pavlidis, Paul, Wan, Xiang, Stark, Kimberly L, Bagchi, Anindya, Hsu, Ruby

“…Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at high risk of developing schizophrenia. We analyzed an engineered…”
Get full text

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids by Deng, Lunbin, Dourado, Michelle, Reese, Rebecca M., Huang, Kevin, Shields, Shannon D., Stark, Kimberly L., Maksymetz, James, Lin, Han, Kaminker, Joshua S., Jung, Min, Foreman, Oded, Tao, Janet, Ngu, Hai, Joseph, Victory, Roose-Girma, Meron, Tam, Lucinda, Lardell, Susanne, Orrhult, Linnea Strid, Karila, Paul, Allard, Julien, Hackos, David H.

“…Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is…”
Get full text

Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues by Stark, Kimberly L., Burt, Rachel A., Gogos, Joseph A., Karayiorgou, Maria

“…Animal models have been useful in elucidating the genetic basis of the cognitive and behavioural phenotypes associated with the 22q11.2 microdeletions…”
Get full text

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion by Karayiorgou, Maria, Gogos, Joseph A, Mukai, Jun, Dhilla, Alefiya, Drew, Liam J, Stark, Kimberly L, Cao, Luxiang, MacDermott, Amy B

“…Microdeletions of the chromosome locus 22q11.2 are linked to a variety of mental and neurological disorders in human, including schizophrenia. Using a mouse…”
Get full text

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models by Patel, Snahel, Cohen, Frederick, Dean, Brian J., De La Torre, Kelly, Deshmukh, Gauri, Estrada, Anthony A., Ghosh, Arundhati Sengupta, Gibbons, Paul, Gustafson, Amy, Huestis, Malcolm P., Le Pichon, Claire E., Lin, Han, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Ly, Cuong Q., Lyssikatos, Joseph P., Ma, Changyou, Scearce-Levie, Kimberly, Shin, Young G., Solanoy, Hilda, Stark, Kimberly L., Wang, Jian, Wang, Bei, Zhao, Xianrui, Lewcock, Joseph W., Siu, Michael

“…Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the…”
Get full text

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism by Schauer, Stephen P., Cho, Chang Hoon, Novikova, Gloriia, Roth, Gillie A., Lee, Julie, Sharma, Anup D., Foley, Alejandro R., Ng, Carl, Shen, Philip, Choi, Meena, Ma, Taylur P., Phu, Lilian, Budayeva, Hanna G., Cheung, Tommy K., Lalehzadeh, Guita, Imperio, Jose, Ngu, Hai, Etxeberria, Ainhoa, Liang, Yuxin, Rezzonico, Mitchell G., Dourado, Michelle, Huang, Kevin, Lai, Zijuan, Hokom, Martha, Pandya, Nikhil J., Newton, Dwight, Abdel‐Haleem, Alyaa M., Chan, Pamela, Lee, Donna, Tassew, Nardos G., Sangaraju, Dewakar, O'Connor, Deborah, Hötzel, Isidro, Stark, Kimberly L., Chou, Carolina, Foreman, Oded, Easton, Amy, Wildsmith, Kristin R., Sperinde, Gizette, Rose, Christopher M., Friedman, Brad A., Fuji, Reina N., Weimer, Robby M., Meilandt, William J., Sadekar, Shraddha, Nugent, Alicia A., Biever, Anne

“…INTRODUCTION Triggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease‐modifying therapeutics for Alzheimer's…”
Get full text

The 22q11.2 microdeletion: Fifteen years of insights into the genetic and neural complexity of psychiatric disorders by Drew, Liam J., Crabtree, Gregg W., Markx, Sander, Stark, Kimberly L., Chaverneff, Florence, Xu, Bin, Mukai, Jun, Fenelon, Karine, Hsu, Pei-Ken, Gogos, Joseph A., Karayiorgou, Maria

“…▶ 22q11.2 deletions are the largest known genetic risk factor of schizophrenia. ▶ 22q11.2 deletions result in specific cognitive and neuroanatomical…”
Get full text

Knockout Mice Reveal Opposite Roles for Serotonin 1A and 1B Receptors in Prepulse Inhibition by Dulawa, Stephanie C, Gross, Cornelius, Stark, Kimberly L, Hen, Rene, Geyer, Mark A

“…The serotonergic system is involved in the modulation of prepulse inhibition (PPI) and habituation of startle, which are deficient in schizophrenia patients…”
Get full text

Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons by Ghavami, A, Stark, K L, Jareb, M, Ramboz, S, Ségu, L, Hen, R

“…The 5-HT1A and 5-HT1B serotonin receptors are expressed in a variety of neurons in the central nervous system. While the 5-HT1A receptor is found on somas and…”
Get full text

Knockout Corner by Stark, Kimberly L., Hen, René

“…Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in a number of physiological functions including sleep, appetite, pain perception, and…”
Get full text

Derepression of a novel neuronal inhibitor is a major outcome of miRNA dysregulation due to 22q11.2 microdeletion by Xu, Bin, Hsu, Pei-Ken, Stark, Kimberly L., Karayiorgou, Maria, Gogos, Joseph A.

“…22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A +/− mice, which model this microdeletion, revealed…”
Get full text

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22qll-deletion mouse model by STARK, Kimberly L, BIN XU, GOGOS, Joseph A, BAGCHI, Anindya, LAI, Wen-Sung, HUI LIU, HSU, Ruby, XIANG WAN, PAVLIDIS, Paul, MILLS, Alea A, KARAYIORGOU, Maria

Get full text