Search Results - "Stariat, Jan"

Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials by Reimerová, Petra, Stariat, Ján, Bavlovič Piskáčková, Hana, Jansová, Hana, Roh, Jaroslav, Kalinowski, Danuta S., Macháček, Miloslav, Šimůnek, Tomáš, Richardson, Des R., Štěrbová-Kovaříková, Petra

“…Solid-phase microextraction (SPME) is an alternative method to dialysis and ultrafiltration for the determination of plasma protein binding (PPB) of drugs. It…”
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Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry by Stariat, Ján, Kovaříková, Petra, Kučera, Radim, Klimeš, Jiří, Kalinowski, Danuta S., Richardson, Des R., Ketola, Raimo A.

“…Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) is a promising analogue of the dipyridyl thiosemicarbazone class currently under development…”
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HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents by Stariat, Ján, Kovaříková, Petra, Klimeš, Jiří, Lovejoy, David B., Kalinowski, Danuta S., Richardson, Des R.

“…The aim of this study was to develop and validate HPLC methods for the determination in plasma of two novel thiosemicarbazone anti-tumour drugs developed in…”
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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents by Sestak, Vit, Stariat, Jan, Cermanova, Jolana, Potuckova, Eliska, Chladek, Jaroslav, Roh, Jaroslav, Bures, Jan, Jansova, Hana, Prusa, Petr, Sterba, Martin, Micuda, Stanislav, Simunek, Tomas, Kalinowski, Danuta S., Richardson, Des R., Kovarikova, Petra

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In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites by Potůčková, Eliška, Roh, Jaroslav, Macháček, Miloslav, Sahni, Sumit, Stariat, Ján, Šesták, Vít, Jansová, Hana, Hašková, Pavlína, Jirkovská, Anna, Vávrová, Kateřina, Kovaříková, Petra, Kalinowski, Danuta S, Richardson, Des R, Šimůnek, Tomáš

“…Cancer cells have a high iron requirement and many experimental studies, as well as clinical trials, have demonstrated that iron chelators are potential…”
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Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites—the cardioprotectant dexrazoxane as a model case by Kovaříková, Petra, Stariat, Ján, Klimeš, Jiří, Hrušková, Kateřina, Vávrová, Kateřina

“…This paper presents a systematic study of the retention behavior of a model bisdioxopiperazine drug, dexrazoxane (DEX) and its three polar metabolites (two…”
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LC–UV/MS methods for the analysis of prochelator—Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH) by Bureš, Jan, Jansová, Hana, Stariat, Ján, Filipský, Tomáš, Mladěnka, Přemysl, Šimůnek, Tomáš, Kučera, Radim, Klimeš, Jiří, Wang, Qin, Franz, Katherine J., Kovaříková, Petra

“…•Salicylaldehyde isonicotinoyl hydrazone (SIH) is an effective cytoprotective agent.•Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) is activated to…”
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LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT by Stariat, Ján, Šesták, Vít, Vávrová, Kateřina, Nobilis, Milan, Kollárová, Zuzana, Klimeš, Jiří, Kalinowski, Danuta S., Richardson, Des R., Kovaříková, Petra

“…The iron chelator, 2-benzoylpyridine-4-ethyl-3-thiosemicarbazone (Bp4eT), was identified as a lead compound of the 2-benzoylpyridine thiosemicarbazone series,…”
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Use of different stationary phases for separation of isoniazid, its metabolites and vitamin B6 forms by Pasáková, Ivana, Gladziszová, Marcela, Charvátová, Jana, Stariat, Ján, Klimeš, Jiří, Kovaříková, Petra

“…The ability of different stationary phases developed for the analysis of polar compounds (ZIC-HILIC, ZIC-pHILIC and Zorbax SB-Aq) to separate isoniazid, its…”
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Synthesis and Initial in Vitro Evaluations of Novel Antioxidant Aroylhydrazone Iron Chelators with Increased Stability against Plasma Hydrolysis by Hruskova, Katerina, Kovarikova, Petra, Bendova, Petra, Haskova, Pavlina, Mackova, Eliska, Stariat, Jan, Vavrova, Anna, Vavrova, Katerina, Simunek, Tomas

“…Oxidative stress is known to contribute to a number of cardiovascular pathologies. Free intracellular iron ions participate in the Fenton reaction and…”
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Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: Application to a pilot pharmacokinetic study in rats by Stariat, Ján, Suprunová, Vlasta, Roh, Jaroslav, Šesták, Vít, Eisner, Tomáš, Filipský, Tomáš, Mladěnka, Přemysl, Nobilis, Milan, Šimůnek, Tomáš, Klimeš, Jiří, Kalinowski, Danuta S., Richardson, Des R., Kovaříková, Petra

“…ABSTRACT Novel thiosemicarbazone metal chelators are extensively studied anti‐cancer agents with marked and selective activity against a wide variety of cancer…”
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Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT by Stariat, Ján, Kovaříková, Petra, Klimeš, Jiří, Kalinowski, Danuta S, Richardson, Des R

“…This study was focused on a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method development for quantification of a novel potential anticancer…”
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Development of LC–MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium by Kovarikova, Petra, Pasakova-Vrbatova, Ivana, Vavrova, Anna, Stariat, Jan, Klimes, Jiri, Simunek, Tomas

“…[Display omitted] ► Dexrazoxane (DEX) is a highly effective, clinically used cardioprotective drug. ► Its mechanism of action still remains elusive. ► This is…”
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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents by Sestak, Vit, Stariat, Jan, Cermanova, Jolana, Potuckova, Eliska, Chladek, Jaroslav, Roh, Jaroslav, Bures, Jan, Jansova, Hana, Prusa, Petr, Sterba, Martin, Micuda, Stanislav, Simunek, Tomas, Kalinowski, Danuta S, Richardson, Des R, Kovarikova, Petra

“…Di(2-pyridyl)ketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di(2-pyridyl)ketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) are novel, highly potent…”
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