Search Results - "Starczynowski, Daniel"

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS by Trowbridge, Jennifer J, Starczynowski, Daniel T

“…With a growing aged population, there is an imminent need to develop new therapeutic strategies to ameliorate disorders of hematopoietic aging, including…”
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IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies by Bennett, Joshua, Starczynowski, Daniel T.

“…Cell intrinsic and extrinsic perturbations to inflammatory signaling pathways are a hallmark of development and progression of hematologic malignancies. The…”
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Chronic immune response dysregulation in MDS pathogenesis by Barreyro, Laura, Chlon, Timothy M., Starczynowski, Daniel T.

“…Chronic innate immune signaling in hematopoietic cells is widely described in myelodysplastic syndromes (MDS), and innate immune pathway activation,…”
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Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease by Rawat, Radhika, Starczynowski, Daniel T, Ntziachristos, Panagiotis

“…Ubiquitination is a versatile and tightly regulated post-translational protein modification with many distinct outcomes affecting protein stability,…”
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HHEX expression drives AML development by Starczynowski, Daniel T.

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TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease by Niederkorn, Madeline, Agarwal, Puneet, Starczynowski, Daniel T.

“…•FHA domain-containing proteins are critical gatekeepers of diverse signaling pathways.•TIFA and TIFAB are critical FHA domain-containing proteins in…”
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Are DDX41 variants of unknown significance and pathogenic variants created equal? by Xie, Zhuoer, Starczynowski, Daniel T

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Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs by Muto, Tomoya, Walker, Callum S., Choi, Kwangmin, Hueneman, Kathleen, Smith, Molly A., Gul, Zartash, Garcia-Manero, Guillermo, Ma, Averil, Zheng, Yi, Starczynowski, Daniel T.

“…Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS…”
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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies by Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.

“…Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have…”
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Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia by Chlon, Timothy M., Stepanchick, Emily, Hershberger, Courtney E., Daniels, Noah J., Hueneman, Kathleen M., Kuenzi Davis, Ashley, Choi, Kwangmin, Zheng, Yi, Gurnari, Carmelo, Haferlach, Torsten, Padgett, Richard A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.

“…DDX41 mutations are the most common germline alterations in adult myelodysplastic syndromes (MDSs). The majority of affected individuals harbor germline…”
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Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome by Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, Beverly, Levi J., Cortelezzi, Agostino, Oliva, Esther N., Cuzzola, Maria, Maciejewski, Jaroslaw P., Mulloy, James C., Starczynowski, Daniel T.

“…Myelodysplastic syndromes (MDSs) arise from a defective hematopoietic stem/progenitor cell. Consequently, there is an urgent need to develop targeted therapies…”
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Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets by Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.

“…Human cancers arise through the sequential acquisition of somatic mutations that create successive clonal populations. Human cancer evolution models could help…”
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Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype by Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob

“…For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al . provide evidence that decreased expression of two miRNAs in…”
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DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy by Stepanchick, Emily, Wilson, Andrew, Sulentic, Analise M., Choi, Kwangmin, Hueneman, Kathleen, Starczynowski, Daniel T., Chlon, Timothy M.

“…Germline heterozygous mutations in DDX41 predispose individuals to hematologic malignancies in adulthood. Most of these DDX41 mutations result in a truncated…”
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Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis by Culver-Cochran, Ashley E., Hassan, Aishlin, Hueneman, Kathleen, Choi, Kwangmin, Ma, Averil, VanCauwenbergh, Brett, O’Brien, Eric, Wunderlich, Mark, Perentesis, John P., Starczynowski, Daniel T.

“…Acute myeloid leukemia (AML) is a deadly hematopoietic malignancy. Although many patients achieve complete remission with standard induction therapy, a…”
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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes by Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T

“…Lenalidomide, which is used to treat myelodysplastic syndrome, kills mutation-bearing hematopoietic cells by increasing expression of the G-protein-coupled…”
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GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis by Niederkorn, Madeline, Starczynowski, Daniel T.

“…Hematopoietic stem cells (HSCs) in the bone marrow (BM) form mature blood cells of all lineages through expansion of lineage-biased progenitors. In a recent…”
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Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling by Varney, Melinda E, Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P, Meetei, Ruhikanta A, Inoue, Jun-ichiro, Starczynowski, Daniel T

“…TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) myelodysplastic syndrome (MDS). Deletion of Tifab…”
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Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia by Fang, Jing, Bolanos, Lyndsey C, Choi, Kwangmin, Liu, Xiaona, Christie, Susanne, Akunuru, Shailaja, Kumar, Rupali, Wang, Dehua, Chen, Xiaoting, Greis, Kenneth D, Stoilov, Peter, Filippi, Marie-Dominique, Maciejewski, Jaroslaw P, Garcia-Manero, Guillermo, Weirauch, Matthew T, Salomonis, Nathan, Geiger, Hartmut, Zheng, Yi, Starczynowski, Daniel T

“…Starczynowski and colleagues show that overexpression of TRAF6 in HSCs induces ubiquitination of the RNA-binding protein hnRNPA1 and alternative splicing of…”
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Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation by Muto, Tomoya, Walker, Callum S, Agarwal, Puneet, Vick, Eric, Sampson, Avery, Choi, Kwangmin, Niederkorn, Madeline, Ishikawa, Chiharu, Hueneman, Kathleen, Varney, Melinda, Starczynowski, Daniel T

“…Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem and progenitor…”
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