Search Results - "Starcevic, Marta"

Identification of Snapin and Three Novel Proteins (BLOS1, BLOS2, and BLOS3/Reduced Pigmentation) as Subunits of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1) by Starcevic, Marta, Dell'Angelica, Esteban C

“…Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a ubiquitously expressed multisubunit protein complex required for the normal biogenesis of…”
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Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein by Kroenke, Mark A, Manning, Marta Starcevic, Zuch de Zafra, Christina L, Zhang, Xinwen, Cook, Kevin D, Archer, Michael, Lolkema, Martijn P, Wang, Jin, Hoofring, Sarah, Saini, Gurleen, Aeffner, Famke, Ahern, Elizabeth, Cabanas, Elena Garralda, Govindan, Ramaswamy, Hui, Mun, Gupta, Shalini, Mytych, Daniel T

“…[This corrects the article DOI: 10.3389/fimmu.2024.1345473.]…”
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BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles by Setty, Subba Rao Gangi, Tenza, Danièle, Truschel, Steven T, Chou, Evelyn, Sviderskaya, Elena V, Theos, Alexander C, Lamoreux, M Lynn, Di Pietro, Santiago M, Starcevic, Marta, Bennett, Dorothy C, Dell'Angelica, Esteban C, Raposo, Graça, Marks, Michael S

“…Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defects in the formation and function of lysosome-related organelles such as…”
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Comparison of Titer and Signal to Noise (S/N) for Determination of Anti-drug Antibody Magnitude Using Clinical Data from an Industry Consortium by Starcevic Manning, Marta, Hassanein, Mohamed, Partridge, Michael A., Jawa, Vibha, Mora, Johanna, Ryman, Josiah, Barker, Breann, Braithwaite, Christian, Carleton, Kevin, Hay, Laura, Hottenstein, Charles, Kubiak, Robert J., Devanarayan, Viswanath

“…During biotherapeutic drug development, immunogenicity is evaluated by measuring anti-drug antibodies (ADAs). The presence and magnitude of ADA responses is…”
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Stratification of Antibody-Positive Subjects by Antibody Level Reveals an Impact of Immunogenicity on Pharmacokinetics by Zhou, Lei, Hoofring, Sarah A., Wu, Yu, Vu, Thuy, Ma, Peiming, Swanson, Steven J., Chirmule, Narendra, Starcevic, Marta

“…The availability of highly sensitive immunoassays enables the detection of antidrug antibody (ADA) responses of various concentrations and affinities. The…”
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Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency by Cheli, Verónica T., Daniels, Richard W., Godoy, Ruth, Hoyle, Diego J., Kandachar, Vasundhara, Starcevic, Marta, Martinez-Agosto, Julian A., Poole, Stephen, DiAntonio, Aaron, Lloyd, Vett K., Chang, Henry C., Krantz, David E., Dell'Angelica, Esteban C.

“…Biogenesis of lysosome-related organelles complex 1 (BLOC-1) is a protein complex formed by the products of eight distinct genes. Loss-of-function mutations in…”
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BLOC-1, a Novel Complex Containing the Pallidin and Muted Proteins Involved in the Biogenesis of Melanosomes and Platelet-dense Granules by Falcón-Pérez, Juan M., Starcevic, Marta, Gautam, Rashi, Dell'Angelica, Esteban C.

“…Recent studies have led to the identification of a group of genes required for normal biogenesis of lysosome-related organelles such as melanosomes and…”
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Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein by Kroenke, Mark A, Starcevic Manning, Marta, Zuch de Zafra, Christina L, Zhang, Xinwen, Cook, Kevin D, Archer, Michael, Lolkema, Martijn P, Wang, Jin, Hoofring, Sarah, Saini, Gurleen, Aeffner, Famke, Ahern, Elizabeth, Cabanas, Elena Garralda, Govindan, Ramaswamy, Hui, Mun, Gupta, Shalini, Mytych, Daniel T

“…AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and a single IL-21 mutein domain on the C-terminus. Nonclinical…”
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Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein by Nazarian, Ramin, Starcevic, Marta, Spencer, Melissa J, Dell'Angelica, Esteban C

“…Dysbindin was identified as a dystrobrevin-binding protein potentially involved in the pathogenesis of muscular dystrophy. Subsequently, genetic studies have…”
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Assay signal as an alternative to titer for assessment of magnitude of an antidrug antibody response by Starcevic Manning, Marta, Kroenke, Mark A, Lee, Stephanie A, Harrison, Simon E, Hoofring, Sarah A, Mytych, Daniel T, Jawa, Vibha

“…Titer methods are commonly used to characterize the magnitude of an antidrug antibody response. Assay S/N is an appealing alternative, but the circumstances…”
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The molecular machinery for the biogenesis of lysosome-related organelles: lessons from Hermansky–Pudlak syndrome by Starcevic, Marta, Nazarian, Ramin, Dell’Angelica, Esteban C

“…Hermansky–Pudlak syndrome (HPS) defines a group of autosomal recessive disorders characterized by defects in lysosome-related organelles such as melanosomes…”
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Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics by Gorovits, Boris, Wakshull, Eric, Pillutla, Renuka, Xu, Yuanxin, Manning, Marta Starcevic, Goyal, Jaya

“…Many biotherapeutics currently in development have complex mechanisms of action and contain more than one domain, each with a specific role or function…”
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Anti-drug Antibody Validation Testing and Reporting Harmonization by Myler, Heather, Pedras-Vasconcelos, João, Phillips, Kelli, Hottenstein, Charles Scott, Chamberlain, Paul, Devanaryan, Viswanath, Gleason, Carol, Goodman, Joanne, Manning, Marta Starcevic, Purushothama, Shobha, Richards, Susan, Shen, Honglue, Zoghbi, Jad, Amaravadi, Lakshmi, Barger, Troy, Bowen, Steven, Bowsher, Ronald R., Clements-Egan, Adrienne, Geng, Dong, Goletz, Theresa J., Gunn, George R., Hallett, William, Hodsdon, Michael E., Janelsins, Brian M., Jawa, Vibha, Kamondi, Szilard, Kirshner, Susan, Kramer, Daniel, Liang, Meina, Lindley, Kathryn, Liu, Susana, Liu, ZhenZhen, McNally, Jim, Mikulskis, Alvydas, Nelson, Robert, Ahbari, Mohsen Rajabi, Qu, Qiang, Ruppel, Jane, Snoeck, Veerle, Song, An, Yan, Haoheng, Ware, Mark

“…Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in…”
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Recommendations for the Assessment and Management of Pre-existing Drug-Reactive Antibodies During Biotherapeutic Development by Xue, Li, Clements-Egan, Adrienne, Amaravadi, Lakshmi, Birchler, Mary, Gorovits, Boris, Liang, Meina, Myler, Heather, Purushothama, Shobha, Manning, Marta Starcevic, Sung, Crystal

“…Anti-drug antibodies (ADA) pose a potential risk to patient safety and efficacy and are routinely monitored during clinical trials. Pre-existing drug-reactive…”
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Anti-drug Antibody Sample Testing and Reporting Harmonization by Jani, Darshana, Marsden, Robin, Gunsior, Michele, Hay, Laura Schild, Ward, Bethany, Cowan, Kyra J., Azadeh, Mitra, Barker, Breann, Cao, Liching, Closson, Kristin R., Coble, Kelly, Dholakiya, Sanjay L., Dusseault, Julie, Hays, Amanda, Herl, Carina, Hodsdon, Michael E., Irvin, Susan C., Kirshner, Susan, Kolaitis, Gerry, Kulagina, Nadia, Kumar, Seema, Lai, Ching Ha, Lipari, Francesco, Liu, Susana, Merdek, Keith D., Moldovan, Ioana R., Mozaffari, Reza, Pan, Luying, Place, Corina, Snoeck, Veerle, Manning, Marta Starcevic, Stocker, Dennis, Tary-Lehmann, Magdalena, Turner, Amy, Vainshtein, Inna, Verthelyi, Daniela, Williams, William T., Yan, Haoheng, Yan, Weili, Yang, Lili, Yang, Lin, Zemo, Jennifer, Zhong, Zhandong Don

“…A clear scientific and operational need exists for harmonized bioanalytical immunogenicity study reporting to facilitate communication of immunogenicity…”
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Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor by Kakkar, Tarundeep, Sung, Cynthia, Gibiansky, Leonid, Vu, Thuy, Narayanan, Adimoolam, Lin, Shao-Lee, Vincent, Michael, Banfield, Christopher, Colbert, Alex, Hoofring, Sarah, Starcevic, Marta, Ma, Peiming

“…ABSTRACT Purpose For AMG 317, a fully human monoclonal antibody to interleukin receptor IL-4Rα, we developed a population pharmacokinetic (PK) model by fitting…”
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Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) by Swank, Richard T, Li, Wei, Zhang, Qing, Oiso, Naoki, Novak, Edward K, Gautam, Rashi, O'Brien, Edward P, Tinsley, Caroline L, Blake, Derek J, Spritz, Richard A, Copeland, Neal G, Jenkins, Nancy A, Amato, Dominick, Roe, Bruce A, Starcevic, Marta, Dell'Angelica, Esteban C, Elliott, Rosemary W, Mishra, Vishnu, Kingsmore, Stephen F, Paylor, Richard E

“…Hermansky-Pudlak syndrome (HPS; MIM 203300) is a genetically heterogeneous disorder characterized by oculocutaneous albinism, prolonged bleeding and pulmonary…”
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Strategic characterization of anti-drug antibody responses for the assessment of clinical relevance and impact by Tatarewicz, Suzanna M, Mytych, Daniel T, Manning, Marta Starcevic, Swanson, Steven J, Moxness, Michael S, Chirmule, Narendra

“…All therapeutic proteins have the potential to induce anti-drug antibodies (ADA). Clinically relevant ADA can impact efficacy and/or safety of a biological…”
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Immunogenicity testing strategy and bioanalytical assays for antibody-drug conjugates by Hoofring, Sarah A, Lopez, Rocio, Hock, M Benjamin, Kaliyaperumal, Arunan, Patel, Sonal K, Swanson, Steven J, Chirmule, Narendra, Starcevic, Marta

“…Immunogenicity testing is an important component of clinical development for large-molecule biotherapeutics. New complex types of large molecules, such as…”
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Quantitative assessment of soluble B7RP-1 in bound and unbound state in normal and Systemic Lupus Erythematosus patients’ plasma (130.4) by Bautista, Ami, Zhou, Lei, Zhang, Ming, Sullivan, Barbara, Belouski, Shelley, Starcevic, Marta, Kaliyaperumal, Arunan, Chirmule, Naren, Jawa, Vibha

“…Abstract Membrane associated receptors can undergo shedding following cross-linking with ligand. B7RP-1 receptor is present on B-cells and macrophages and…”
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