Search Results - "Star, R A"

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery by Zhou, H., Yuen, P.S.T., Pisitkun, T., Gonzales, P.A., Yasuda, H., Dear, J.W., Gross, P., Knepper, M.A., Star, R.A.

“…Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein…”
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Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects by Yasuda, H., Yuen, P.S.T., Hu, X., Zhou, H., Star, R.A.

“…Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of AKI with sepsis is extremely high. An effective therapeutic…”
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Exosomes from human saliva as a source of microRNA biomarkers by Michael, A, Bajracharya, SD, Yuen, PST, Zhou, H, Star, RA, Illei, GG, Alevizos, I

“…Objective:  The aim of this study was to examine the presence of microRNAs (miRNAs) within exosomes isolated from human saliva and to optimize and test methods…”
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Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury by Zhou, H., Pisitkun, T., Aponte, A., Yuen, P.S.T., Hoffert, J.D., Yasuda, H., Hu, X., Chawla, L., Shen, R.-F., Knepper, M.A., Star, R.A.

“…Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein…”
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Treatment of acute renal failure by Star, Robert A.

“…Treatment of acute renal failure. Acute renal failure is a life threatening illness whose mortality has remained high since the introduction of hemodialysis…”
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Frequent Hemodialysis Network (FHN) randomized trials: Study design by Suri, R.S., Garg, A.X., Chertow, G.M., Levin, N.W., Rocco, M.V., Greene, T., Beck, G.J., Gassman, J.J., Eggers, P.W., Star, R.A., Ornt, D.B., Kliger, A.S., for the Frequent Hemodialysis Network (FHN) Trail Group

“…Observational studies suggest improvements with frequent hemodialysis (HD), but its true efficacy and safety remain uncertain. The Frequent Hemodialysis…”
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AP214, an analogue of α-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality by Doi, K., Hu, X., Yuen, P.S.T., Leelahavanichkul, A., Yasuda, H., Kim, S.M., Schnermann, J., Jonassen, T.E.N., Frøkiær, J., Nielsen, S., Star, R.A.

“…Sepsis remains a serious problem in critically ill patients with the mortality increasing to over half when there is attendant acute kidney injury…”
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Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: Acute renal failure is dependent on MyD88 but not renal cell apoptosis by Dear, J.W., Yasuda, H., Hu, X., Hieny, S., Yuen, P.S.T., Hewitt, S.M., Sher, A., Star, R.A.

“…Toll-like receptors (TLRs) are important in sepsis. Myeloid differentiation factor 88 (MyD88) is a key molecule involved in signal transduction by multiple…”
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Exosomes from human saliva as a source of microRNA biomarkers by Michael, A, Bajracharya, SD, Yuen, PST, Zhou, H, Star, RA, Illei, GG, Alevizos, I

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Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure by Holly, M.K., Dear, J.W., Hu, X., Schechter, A.N., Gladwin, M.T., Hewitt, S.M., Yuen, P.S.T., Star, R.A.

“…Sepsis is one of the common causes of acute renal failure (ARF). The objective of this study was to identify new biomarkers and therapeutic targets. We present…”
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Urine Exosomes: An Emerging Trove of Biomarkers by Street, J M, Koritzinsky, E H, Glispie, D M, Star, R A, Yuen, P S T

“…Exosomes are released by most cells and can be isolated from all biofluids including urine. Exosomes are small vesicles formed as part of the endosomal pathway…”
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Lymphatic Drainage Imaging of Breast Cancer in Mice by Micro-Magnetic Resonance Lymphangiography Using a Nano-Size Paramagnetic Contrast Agent by Kobayashi, Hisataka, Kawamoto, Satomi, Sakai, Yoshio, Choyke, Peter L., Star, Robert A., Brechbiel, Martin W., Sato, Noriko, Tagaya, Yutaka, Morris, John C., Waldmann, Thomas A.

“…Background: The presence of lymph node metastases is an important factor in breast cancer patient prognosis. Therefore, the precise identification of sentinel…”
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Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats by Chiao, H, Kohda, Y, McLeroy, P, Craig, L, Housini, I, Star, R A

“…Reperfusion after ischemia induces cytokines, chemoattractant chemokines, adhesion molecules, and nitric oxide (NO). The resultant neutrophil adherence and NO…”
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alpha-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line by Rajora, N., Ceriani, G., Catania, A., Star, R.A., Murphy, M.T., Lipton, J.M.

“…α‐Melanocyte‐stimulating hormone (α‐MSH), a tridecapeptide derived from pro‐opiomelanocortin, has potent antiinflammatory activity in laboratory animals. α‐MSH…”
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Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung by Shaul, P W, North, A J, Brannon, T S, Ujiie, K, Wells, L B, Nisen, P A, Lowenstein, C J, Snyder, S H, Star, R A

“…Prolonged hypoxia in the adult rat causes a decline in endothelium-derived nitric oxide (NO) production in the pulmonary circulation. To evaluate whether this…”
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Analysis of segmental renal gene expression by laser capture microdissection by Kohda, Yukimasa, Murakami, Hiroshi, Moe, Orson W., Star, Robert A.

“…Analysis of segmental renal gene expression by laser capture microdissection. The study of normal renal physiology has been greatly aided by microdissection…”
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Evidence of Autocrine Modulation of Macrophage Nitric Oxide Synthase by α-Melanocyte-Stimulating Hormone by Star, Robert A., Rajora, Nilum, Huang, Jijing, Stock, Renee C., Catania, Anna, Lipton, J. M.

“…α-Melanocyte-stimulating hormone (α-MSH) is a potent inhibitory agent in all major forms of inflammation. To identify a potential mechanism of antiinflammatory…”
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Localization and regulation of endothelial NO synthase mRNA expression in rat kidney by Ujiie, K, Yuen, J, Hogarth, L, Danziger, R, Star, R A

“…Nitric oxide (NO) has effects on renal blood flow, glomerular filtration rate, renin secretion, and renal sodium excretion. Four isoforms of nitric oxide…”
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Membrane localization of H+ and HCO3- transporters in the rat pancreatic duct by ZHAO, H, STAR, R. A, MUALLEM, S

“…The pancreatic duct secretes alkaline fluid that is rich in HCO3- and poor in Cl-. The molecular mechanisms that mediate ductal secretion and are responsible…”
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α-Melanocyte-stimulating hormone inhibits renal injury in the absence of neutrophils by Chiao, Hsi, Kohda, Yukimasa, McLeroy, Paul, Craig, Leonard, Linas, Stuart, Star, Robert A.

“…α-Melanocyte-stimulating hormone inhibits neutrophil-independent renal injury. We previously showed that α-melanocyte stimulating hormone (α-MSH) decreases…”
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