Search Results - "Stapleton, Phoebe A"

The Application of Engineered Nanomaterials in Perinatal Therapeutics by Stapleton, Phoebe A.

“…Pregnancy is a vulnerable life stage for the mother and developing fetus. Because of this dual concern, approved therapeutic options for pre‐existing…”
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Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy by Fournier, Sara B, D'Errico, Jeanine N, Adler, Derek S, Kollontzi, Stamatina, Goedken, Michael J, Fabris, Laura, Yurkow, Edward J, Stapleton, Phoebe A

“…Abstract Background Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable…”
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Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats by Cary, Chelsea M, Seymore, Talia N, Singh, Dilpreet, Vayas, Kinal N, Goedken, Michael J, Adams, Samantha, Polunas, Marianne, Sunil, Vasanthi R, Laskin, Debra L, Demokritou, Philip, Stapleton, Phoebe A

“…Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in…”
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Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation by Fournier, Sara B., Lam, Vincent, Goedken, Michael J., Fabris, Laura, Stapleton, Phoebe A.

“…Maternal exposure to environmental contaminants during pregnancy can profoundly influence the risk of developing cardiovascular disease in adult offspring. Our…”
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Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? by Stapleton, Phoebe A., PhD, Minarchick, Valerie C., BS, Yi, Jinghai, PhD, Engels, Kevin, BS, McBride, Carroll R., BS, Nurkiewicz, Timothy R., PhD

“…Objective The continued development and use of engineered nanomaterials (ENM) has given rise to concerns over the potential for human health effects. Although…”
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Vascular distribution of nanomaterials by Stapleton, Phoebe A., Nurkiewicz, Timothy R.

“…Once considered primarily occupational, novel nanotechnology innovations, and applications have led to widespread domestic use and intentional biomedical…”
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Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications by Cary, Chelsea M, DeLoid, Glen M, Yang, Zhenning, Bitounis, Dimitrios, Polunas, Marianne, Goedken, Michael J, Buckley, Brian, Cheatham, Byron, Stapleton, Phoebe A, Demokritou, Philip

“…Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes…”
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Cerium Dioxide Nanoparticle Exposure Improves Microvascular Dysfunction and Reduces Oxidative Stress in Spontaneously Hypertensive Rats by Minarchick, Valerie C, Stapleton, Phoebe A, Sabolsky, Edward M, Nurkiewicz, Timothy R

“…The elevated production of reactive oxygen species (ROS) in the vascular wall is associated with cardiovascular diseases such as hypertension. This increase in…”
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Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study by Stapleton, Phoebe A, Minarchick, Valerie C, Cumpston, Amy M, McKinney, Walter, Chen, Bean T, Sager, Tina M, Frazer, David G, Mercer, Robert R, Scabilloni, James, Andrew, Michael E, Castranova, Vincent, Nurkiewicz, Timothy R

“…Engineered nanomaterials have been developed for widespread applications due to many highly unique and desirable characteristics. The purpose of this study was…”
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Hypercholesterolemia and microvascular dysfunction: interventional strategies by Stapleton, Phoebe A, Goodwill, Adam G, James, Milinda E, Brock, Robert W, Frisbee, Jefferson C

“…Hypercholesterolemia is defined as excessively high plasma cholesterol levels, and is a strong risk factor for many negative cardiovascular events. Total…”
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Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition by Engler-Chiurazzi, Elizabeth B., Stapleton, Phoebe A., Stalnaker, Jessica J., Ren, Xuefang, Hu, Heng, Nurkiewicz, Timothy R., McBride, Carroll R., Yi, Jinghai, Engels, Kevin, Simpkins, James W.

“…It is generally accepted that gestational xenobiotic exposures result in systemic consequences in the adult F1 generation. However, data on detailed behavioral…”
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Heterogeneous Vascular Bed Responses to Pulmonary Titanium Dioxide Nanoparticle Exposure by Abukabda, Alaeddin B, Stapleton, Phoebe A, McBride, Carroll R, Yi, Jinghai, Nurkiewicz, Timothy R

“…A growing body of research links engineered nanomaterial (ENM) exposure to adverse cardiovascular endpoints. The purpose of this study was to evaluate the…”
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Uterine Microvascular Dysfunction After Plastic Particle Inhalation by Cary, Chelsea C., Seymore, Talia N., Stapleton, Phoebe A.

“…Adverse cardiovascular and inflammatory outcomes after airborne particulate matter (PM) inhalation have long been a topic of epidemiological studies. Previous…”
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Developmental onset of cardiovascular disease—Could the proof be in the placenta? by D'Errico, Jeanine N., Stapleton, Phoebe A.

“…The Barker Hypothesis states change to the maternal environment may have significant impacts on fetal development, setting the stage for adult disease to…”
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Identification of micro- and nanoplastic particles in postnatal sprague-dawley rat offspring after maternal inhalation exposure throughout gestation by Moreno, Gina M., Brunson-Malone, Tanisha, Adams, Samantha, Nguyen, Calla, Seymore, Talia N., Cary, Chelsea M., Polunas, Marianne, Goedken, Michael J., Stapleton, Phoebe A.

“…Micro-nanoplastic particulates (MNPs) have been identified in both indoor and outdoor environments. From these real-world exposures, MNPs have been identified…”
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Phthalate Exposures and Placental Health in Animal Models and Humans: A Systematic Review by Seymore, Talia N, Rivera-Núñez, Zorimar, Stapleton, Phoebe A, Adibi, Jennifer J, Barrett, Emily S

“…Abstract Phthalates are ubiquitous compounds known to leach from the plastic products that contain them. Due to their endocrine-disrupting properties, a wide…”
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Differential Impact of Familial Hypercholesterolemia and Combined Hyperlipidemia on Vascular Wall and Network Remodeling in Mice by STAPLETON, PHOEBE A., GOODWILL, ADAM G., JAMES, MILINDA E., D'AUDIFFRET, ALEXANDRE C., FRISBEE, JEFFERSON C.

“…Microcirculation (2010) 17, 47–58. doi: 10.1111/j.1549‐8719.2009.00003.x Genetic familial hypercholesterolemia (FH) and combined hyperlipidemia (FCH) are…”
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Maternal-engineered nanomaterial exposure disrupts progeny cardiac function and bioenergetics by Hathaway, Quincy A, Nichols, Cody E, Shepherd, Danielle L, Stapleton, Phoebe A, McLaughlin, Sarah L, Stricker, Janelle C, Rellick, Stephanie L, Pinti, Mark V, Abukabda, Alaeddin B, McBride, Carroll R, Yi, Jinghai, Stine, Seth M, Nurkiewicz, Timothy R, Hollander, John M

“…Nanomaterial production is expanding as new industrial and consumer applications are introduced. Nevertheless, the impacts of exposure to these compounds are…”
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Emerging topics in microvascular research: Advancing our understanding by interdisciplinary exploration by Butcher, Joshua T., Murfee, Walter L., Stapleton, Phoebe A.

“…Historically, major advances in microvascular research have been made by integrating physiology and bioengineering approaches. This Special Topics Issue…”
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The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence? by Halvorson, Brayden D, Menon, Nithin J, Goldman, Daniel, Frisbee, Stephanie J, Goodwill, Adam G, Butcher, Joshua T, Stapleton, Phoebe A, Brooks, Steven D, d'Audiffret, Alexandre C, Wiseman, Robert W, Lombard, Julian H, Brock, Robert W, Olfert, I Mark, Chantler, Paul D, Frisbee, Jefferson C

“…The study of peripheral vasculopathy with chronic metabolic disease is challenged by divergent contributions from spatial (the level of resolution or specific…”
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