Search Results - "Stapleton, PP"

Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model by Matsuda, Takeaki, Freeman, Tracy A., Hilbert, David W., Duff, Michael, Fuortes, Michele, Stapleton, Philip P., Daly, John M.

“…Lysis-deficient (LyD) bacteriophages (phages) kill bacteria without endotoxin (Et) release. This may minimize systemic cytokine responses and limit…”
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Immunonutrition: the role of taurine by Redmond, H.Paul, Stapleton, P.P., Neary, Paul, Bouchier-Hayes, David

“…Taurine is a sulfonated β amino acid derived from methionine and cysteine metabolism. It is present in high concentrations in most tissues and in particular in…”
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Glucocorticoid pretreatment induces cytokine overexpression and nuclear factor-κB activation in macrophages by Smyth, Gordon P., Stapleton, Philip P., Freeman, Tracy A., Concannon, Erin M., Mestre, Juan R., Duff, Michael, Maddali, Sirish, Daly, John M.

“…Glucocorticoids are widely used in treating inflammatory diseases. The contribution of adrenal glucocorticoids to inflammatory regulation is unknown…”
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Malnutrition-induced macrophage apoptosis by Rivadeneira, David E., Grobmyer, Stephen R., Naama, Hassan A., Mackrell, Peter J., Mestre, Juan R., Stapleton, Philip P., Daly, John M.

“…Background. Human and murine studies suggest protein-calorie malnutrition (PCM) results in significant host immunosuppression resulting in increased morbidity…”
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Enhanced expression of cyclooxygenase-2 and prostaglandin E 2 in response to endotoxin after trauma is dependent on MAPK and NF-κB mechanisms by Yan, Zhaoping, Stapleton, Philip P., Freeman, Tracy A., Fuortes, Michele, Daly, John M.

“…Macrophage prostaglandin E 2 (PGE 2) production is important in cellular immune suppression and in affecting the potential development of sepsis after trauma…”
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Renal cell carcinoma induces prostaglandin E2 and T-helper type 2 cytokine production in peripheral blood mononuclear cells by Smyth, Gordon P, Stapleton, Philip P, Barden, Catherine B, Mestre, Juan R, Freeman, Tracy A, Duff, Michael D, Maddali, Sirish, Yan, Zhaoping, Daly, John M

“…Patients with renal cell carcinoma (RCC) do not develop an effective antitumor immune response, despite significant infiltration by lymphocytes. Tumor…”
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NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model by Nishikawa, Masayasu, Stapleton, Philip P., Freeman, Tracy A., Gaughan, John P., Matsuda, Takeaki, Daly, John M.

“…Cyclooxygenase-2 (COX-2) is overexpressed in colon cancers. The plasminogen activation (PA) system relates to cancer invasion and metastasis through the…”
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Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma by Duff, Michael, Stapleton, Philip P, Mestre, Juan R, Maddali, Sirish, Smyth, Gordon P, Yan, Zhaoping, Freeman, Tracy A, Daly, John M

“…Melanoma inhibits macrophage tumoricidal activity and increases the expression of cyclooxygenase-2 (COX-2). In this study, we sought to determine whether…”
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Neuroendocrine responses mediate macrophage function after trauma by Maddali, Sirish, Stapleton, Philip P., Freeman, Tracy A., Smyth, Gordon P., Duff, Michael, Yan, Zhaoping, Daly, John M.

“…Clearly understanding the interactions between macrophage (Mφ)-generated inflammatory mediators and the neuroendocrine system in regulating immune function…”
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Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice by Fujita, Junya, Marino, Michael W., Wada, Hisashi, Jungbluth, Achim A., Mackrell, Peter J., Rivadeneira, David E., Stapleton, Philip P., Daly, John M.

“…Background. Tumor necrosis factor-α (TNF) is thought to act as a stimulator for initiating hepatocyte proliferation after partial hepatectomy (PH). At the same…”
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Taurine and human nutrition by Stapleton, P.P., Charles, R.P., Redmond, H.P., Bouchier-Hayes, D.J.

“…Taurine (2-aminoethane sulphonic acid), a ubiquitous β-amino acid not incorporated into proteins but found either free or in some simple peptides is considered…”
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Overlapping CRE and E-box promoter elements can independently regulate COX-2 gene transcription in macrophages by Mestre, Juan R., Rivadeneira, David E., Mackrell, Peter J., Duff, Michael, Stapleton, Philip P., Mack-Strong, Vivian, Maddali, Sirish, Smyth, Gordon P., Tanabe, Tadashi, Daly, John M.

“…Macrophage cyclooxygenase-2 (COX-2) transcription is mediated through the collaboration of different promoter elements. Here, the role of an overlapping cyclic…”
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Host defense : A role for the amino acid taurine? by STAPLETON, P.-P, O'FLAHERTY, L, REDMOND, H. P, BOUCHER-HAYES, D. J

“…Taurine (2-aminoethane sulphonic acid), a ubiquitous beta-amino acid is conditionally essential in man. It is not utilized in protein synthesis but found free…”
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Decreased peritoneal macrophage NF-κB translocation to the nucleus in protein energy malnutrition—a role for the glucocorticoid response? by Stapleton, Philip P, Barry, Linda K, Freeman, Tracy A, Mestre, Juan R, Daly, John M

“…Background & aims: Protein energy malnutrition (PEM) induces immune suppression leading to increased morbidity and mortality. The mechanism(s) underlying…”
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NS-398 Treatment after Trauma Modifies NF-κB Activation and Improves Survival by Mack Strong, V.E., Mackrell, P.J., Concannon, E.M., Mestre, J.R., Smyth, Gordon P., Schaefer, P.A., Stapleton, P.P., Daly, J.M.

“…Prostaglandin E2 (PGE2) production after trauma contributes to immune alterations that increase susceptibility to infections. We hypothesize that blocking PGE2…”
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Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma by Mackrell, Peter J., Daly, John M., Mestre, Juan R., Stapleton, Philip P., Howe, Louise R., Subbaramaiah, Kotha, Dannenberg, Andrew J.

“…Background. Cyclooxygenase-2 (Cox-2), the inducible form of Cox, is a rate-limiting enzyme in the synthesis of prostaglandins (PGs). Prostaglandin E2 (PGE2)…”
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The influence of restricted calorie intake on peritoneal macrophage function by Stapleton, Philip P, Fujita, Junya, Murphy, Erin M, Naama, Hassan A, Daly, John M

“…Malnutrition leads to immune dysfunction with greatly increased morbidity. However, restrictive dietary regimens are also known to preserve immune function in…”
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Prostaglandins Regulate Melanoma-Induced Cytokine Production in Macrophages by Eisengart, Charles A., Mestre, Juan R., Naama, Hassan A., Mackrell, Peter J., Rivadeneira, David E., Murphy, Erin M., Stapleton, Philip P., Daly, John M.

“…Tumor-secreted products can affect macrophage cytokine expression and in that way alter the immune response. Prostaglandins (PGs) are found in the tumor…”
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Altered cyclooxygenase-2 expression and nitric oxide metabolism following major elective surgery by Maddali, Sirish, Stapleton, Philip P., Freeman, Tracy A., Yan, Zhaoping, Duff, Michael, Smyth, Gordon P., Daly, John M.

“…Postoperative variation in immune function leads to increased susceptibility to infections. Cyclooxygenase-2 (COX-2)-generated Prostaglandin-E 2 (PGE 2), which…”
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Intestinal taurine transport: a review by O'FLAHERTY, L., STAPLETON, P. P., REDMOND, H. P., BOUCHIER-HAYES, D. J.

“…Intestinal uptake of dietary taurine is an important contributor to taurine homeostasis and may become crucial when taurine metabolism is impaired. This review…”
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