Search Results - "Stapleton, Nigel M"

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential by Stapleton, Nigel M., Andersen, Jan Terje, Stemerding, Annette M., Bjarnarson, Stefania P., Verheul, Ruurd C., Gerritsen, Jacoline, Zhao, Yixian, Kleijer, Marion, Sandlie, Inger, de Haas, Masja, Jonsdottir, Ingileif, van der Schoot, C. Ellen, Vidarsson, Gestur

“…Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to…”
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On the perplexingly low rate of transport of IgG2 across the human placenta by Einarsdottir, Helga K, Stapleton, Nigel M, Scherjon, Sicco, Andersen, Jan Terje, Rispens, Theo, van der Schoot, C Ellen, Vidarsson, Gestur

“…The neonatal receptor, FcRn, mediates both serum half-life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore,…”
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The multiple facets of FcRn in immunity by Stapleton, Nigel M., Einarsdóttir, Helga K., Stemerding, Annette M., Vidarsson, Gestur

“…Summary The neonatal Fc receptor, FcRn, is best known for its role in transporting IgG in various tissues, providing newborns with humoral immunity, and for…”
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FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis by Vidarsson, Gestur, Stemerding, Annette M., Stapleton, Nigel M., Spliethoff, Suzanne E., Janssen, Hans, Rebers, Frank E., de Haas, Masja, van de Winkel, Jan G.

“…Here, we report that the MHC class I-related neonatal Fc receptor (FcRn) is expressed within azurophilic and specific granules of neutrophils and relocates to…”
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Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge by Stapleton, Nigel M., Brinkhaus, Maximilian, Armour, Kathryn L., Bentlage, Arthur E. H., de Taeye, Steven W., Temming, A. Robin, Mok, Juk Yee, Brasser, Giso, Maas, Marielle, van Esch, Wim J. E., Clark, Mike R., Williamson, Lorna M., van der Schoot, C. Ellen, Vidarsson, Gestur

“…Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers,…”
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Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport by Stapleton, Nigel M., Armstrong-Fisher, Sylvia S., Andersen, Jan Terje, van der Schoot, C. Ellen, Porter, Charlene, Page, Kenneth R., Falconer, Donald, de Haas, Masja, Williamson, Lorna M., Clark, Michael R., Vidarsson, Gestur, Armour, Kathryn L.

“…•IgG1 modified to reduce cytotoxicity (G1Δnab) has impaired FcRn-mediated function.•G1Δnab variants bind FcRn in a pH-dependent manner but with altered…”
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On the Perplexingly Low Rate of Transport of IgG2 across the Human Placenta: e108319 by Einarsdottir, Helga K, Stapleton, Nigel M, Scherjon, Sicco, Andersen, Jan Terje, Rispens, Theo, Schoot, Ellen vander, Vidarsson, Gestur

“…The neonatal receptor, FcRn, mediates both serum half-life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore,…”
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FcRn : an IgG receptor on phagocytes with a novel role in phagocytosis. Commentary by DOWNEY, Gregory P, VIDARSSON, Gestur, STEMERDING, Annette M, STAPLETON, Nigel M, SPLIETHOFF, Suzanne E, JANSSEN, Hans, REBERS, Frank E, DE HAAS, Masja, VAN DE WINKEL, Jan G

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