Search Results - "Stapleton, Genevieve"

Combined Extracellular Matrix Cross-linking Activity of the Peroxidase MLT-7 and the Dual Oxidase BLI-3 Is Critical for Post-embryonic Viability in Caenorhabditis elegans by Thein, Melanie C., Winter, Alan D., Stepek, Gillian, McCormack, Gillian, Stapleton, Genevieve, Johnstone, Iain L., Page, Antony P.

“…The nematode cuticle is a protective collagenous extracellular matrix that is modified, cross-linked, and processed by a number of key enzymes. This…”
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Cyp7b, a Novel Brain Cytochrome P450, Catalyzes the Synthesis of Neurosteroids 7α -hydroxy Dehydroepiandrosterone and 7α -hydroxy Pregnenolone by Rose, Ken A., Stapleton, Genevieve, Dott, Karin, Kieny, Marie Paule, Best, Ruth, Schwarz, Margrit, Russell, David W., Björkhem, Ingemar, Seckl, Jonathan, Lathe, Richard

“…Steroids produced locally in brain (neurosteroids), including dehydroepiandrosterone (DHEA), influence cognition and behavior. We previously described a novel…”
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A Novel Cytochrome P450 Expressed Primarily in Brain(∗) by Stapleton, Genevieve, Steel, Muriel, Richardson, Melville, Mason, John O., Rose, Ken A., Morris, Richard G.M., Lathe, Richard

“…hct-1 (hippocampal transcript) was detected in a differential screen of a rat hippocampal cDNA library. Expression of hct-1 was enriched in the formation but…”
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Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10 by O'Garra, A, Stapleton, G, Dhar, V, Pearce, M, Schumacher, J, Rugo, H, Barbis, D, Stall, A, Cupp, J, Moore, K

“…We have examined a panel of murine Ly-1+ B lymphomas and purified normal murine peritoneal B cells separated into subsets on the basis of expression of the…”
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Why The Flipped Lecture Is Not A ‘One Size Fits All’ Solution To Undergraduate Medical Education by STAPLETON, GENEVIEVE, PRICE, KATHERINE, SNEDDON, SHARON

“…Lectures underpin most medical school curricula; however, due to their frequently didactic nature, their pedagogical efficacy and value are continually…”
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Bridging the transition to a new expertise in the scholarship of teaching and learning through a faculty learning community by Bailey, Emma, Le Vin, Ashley, Miller, Louise, Price, Katherine, Sneddon, Sharon, Stapleton, Genevieve, Wolfe, Lissann

“…As the higher education landscape changes, teaching-only faculty face increasing challenges to deliver evidence-based teaching through engaging with the…”
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Neurosteroid Hydroxylase CYP7B by Rose, Ken, Allan, Adrian, Gauldie, Stephan, Stapleton, Genevieve, Dobbie, Lorraine, Dott, Karin, Martin, Cécile, Wang, Ling, Hedlund, Eva, Seckl, Jonathan R., Gustafsson, Jan-Åke, Lathe, Richard

“…The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern…”
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Lessons learned from problem‐based learning by Burke, Joanne, Ditchfield, Carol, Flynn, Margaret‐Ann, Sneddon, Sharon, Stapleton, Genevieve

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Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation by Rose, K, Allan, A, Gauldie, S, Stapleton, G, Dobbie, L, Dott, K, Martin, C, Wang, L, Hedlund, E, Seckl, J R, Gustafsson, J A, Lathe, R

“…The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern…”
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Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells by Stapleton, Genevieve, Malliri, Angeliki, Ozanne, Bradford W

“…Progression to an invasive, metastatic tumour requires the coordinated expression and function of a number of gene products, as well as their regulation in the…”
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Regulation of a multigenic invasion programme by the transcription factor, AP-1 : re-expression of a down-regulated gene, TSC-36, inhibits invasion by JOHNSTON, Imogen M. P, SPENCE, Heather J, WINNIE, Joseph N, MCGARRY, Lynn, VASS, J. Keith, MEAGHER, Liam, STAPLETON, Genevieve, OZANNE, Bradford W

“…The transcription factor AP-1 (activator protein-1) is required for transformation by many oncogenes, which function upstream of it in the growth factor-ras…”
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Protein Kinase C-Related Kinase 2 Phosphorylates the Protein Synthesis Initiation Factor eIF4E in Starfish Oocytes by Lee, Shyh-Jye, Stapleton, Genevieve, Greene, Julia H., Hille, Merrill B.

“…Phosphorylation of eIF4E is required for protein synthesis during starfish oocyte maturation. The activity of protein kinase C-related kinase 2 (PRK2)…”
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Phosphorylation of Protein Kinase C-Related Kinase PRK2 during Meiotic Maturation of Starfish Oocytes by Stapleton, Genevieve, Nguyen, Cuong P., Lease, Kevin A., Hille, Merrill B.

“…The resumption of meiosis in the developing starfish oocyte is the result of intracellular signaling events initiated by 1-methyladenine stimulation. One of…”
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Gene expression in the hippocampus: identification of a novel cytochrome p-450 by Stapleton, Genevieve

“…The exact mechanism by which the hippocampus contributes to memory formation, and the underlying molecular and biochemical processes are not understood. One…”
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Cell type-specific interactions of transcription factors with a housekeeping promoter in vivo by Stapleton, Genevieve, Patrizia Somma, Maria, Lavia, Patrizia

“…Mammalian housekeeping promoters represent a class of regulatory elements different from those of tissues-specific genes, lacking a TATA box and associated…”
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