Search Results - "Stapleford, Kenneth"

Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect models by Rozen-Gagnon, Kathryn, Stapleford, Kenneth A, Mongelli, Vanesa, Blanc, Hervé, Failloux, Anna-Bella, Saleh, Maria-Carla, Vignuzzi, Marco

“…Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt to disparate hosts while maintaining genetic integrity during genome…”
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Platelets contribute to disease severity in COVID‐19 by Barrett, Tessa J., Bilaloglu, Seda, Cornwell, Macintosh, Burgess, Hannah M., Virginio, Vitor W., Drenkova, Kamelia, Ibrahim, Homam, Yuriditsky, Eugene, Aphinyanaphongs, Yin, Lifshitz, Mark, Xia Liang, Feng, Alejo, Julie, Smith, Grace, Pittaluga, Stefania, Rapkiewicz, Amy V., Wang, Jun, Iancu‐Rubin, Camelia, Mohr, Ian, Ruggles, Kelly, Stapleford, Kenneth A., Hochman, Judith, Berger, Jeffrey S.

“…Objective Heightened inflammation, dysregulated immunity, and thrombotic events are characteristic of hospitalized COVID‐19 patients. Given that platelets are…”
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Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements by Stapleford, Kenneth A, Moratorio, Gonzalo, Henningsson, Rasmus, Chen, Rubing, Matheus, Séverine, Enfissi, Antoine, Weissglas-Volkov, Daphna, Isakov, Ofer, Blanc, Hervé, Mounce, Bryan C, Dupont-Rouzeyrol, Myrielle, Shomron, Noam, Weaver, Scott, Fontes, Magnus, Rousset, Dominique, Vignuzzi, Marco

“…Chikungunya virus (CHIKV), an alphavirus and member of the Togaviridae family, is capable of causing severe febrile disease in humans. In December of 2013 the…”
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Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses by Mounce, Bryan C., Poirier, Enzo Z., Passoni, Gabriella, Simon-Loriere, Etienne, Cesaro, Teresa, Prot, Matthieu, Stapleford, Kenneth A., Moratorio, Gonzalo, Sakuntabhai, Anavaj, Levraud, Jean-Pierre, Vignuzzi, Marco

“…Polyamines are small, positively charged molecules derived from ornithine and synthesized through an intricately regulated enzymatic pathway. Within cells,…”
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Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes by STAPLEFORD, Kenneth A, LINDENBACH, Brett D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection by Jang, Kyung Ku, Kaczmarek, Maria E, Dallari, Simone, Chen, Ying-Han, Tada, Takuya, Axelrad, Jordan, Landau, Nathaniel R, Stapleford, Kenneth A, Cadwell, Ken

“…Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly variable for reasons that are not understood. In this study, we used…”
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Virus-derived DNA drives mosquito vector tolerance to arboviral infection by Goic, Bertsy, Stapleford, Kenneth A., Frangeul, Lionel, Doucet, Aurélien J., Gausson, Valérie, Blanc, Hervé, Schemmel-Jofre, Nidia, Cristofari, Gael, Lambrechts, Louis, Vignuzzi, Marco, Saleh, Maria-Carla

“…Mosquitoes develop long-lasting viral infections without substantial deleterious effects, despite high viral loads. This makes mosquitoes efficient vectors for…”
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Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication by Burgess, Hannah M., Depledge, Daniel P., Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C., Vink, Elizabeth I., Abebe, Jonathan S., Blackaby, Wesley P., Hendrick, Alan, Albertella, Mark R., Kouzarides, Tony, Stapleford, Kenneth A., Wilson, Angus C., Mohr, Ian

“…In this study, Burgess et al. show that replication of SARS-CoV-2, the agent responsible for the COVID-19 pandemic, and a seasonal human β-coronavirus,…”
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The La Crosse virus class II fusion glycoprotein ij loop contributes to infectivity and replication in vitro and in vivo by Thannickal, Sara A, Spector, Sophie N, Stapleford, Kenneth A

“…Arthropod-borne viruses (arboviruses) are an emerging and evolving global public health threat, with limited antiviral treatments or vaccines available. La…”
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Special Issue "Transmission Dynamics of Insect Viruses" by Stapleford, Kenneth A

“…At the close of this Special Issue of on the Transmission Dynamics of Insect Viruses, we would like to thank all of the authors for their submissions and the…”
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SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2 by Lu, Qiao, Liu, Jia, Zhao, Shuai, Gomez Castro, Maria Florencia, Laurent-Rolle, Maudry, Dong, Jianbo, Ran, Xiaojuan, Damani-Yokota, Payal, Tang, Hongzhen, Karakousi, Triantafyllia, Son, Juhee, Kaczmarek, Maria E., Zhang, Ze, Yeung, Stephen T., McCune, Broc T., Chen, Rita E., Tang, Fei, Ren, Xianwen, Chen, Xufeng, Hsu, Jack C.C., Teplova, Marianna, Huang, Betty, Deng, Haijing, Long, Zhilin, Mudianto, Tenny, Jin, Shumin, Lin, Peng, Du, Jasper, Zang, Ruochen, Su, Tina Tianjiao, Herrera, Alberto, Zhou, Ming, Yan, Renhong, Cui, Jia, Zhu, James, Zhou, Qiang, Wang, Tao, Ma, Jianzhu, Koralov, Sergei B., Zhang, Zemin, Aifantis, Iannis, Segal, Leopoldo N., Diamond, Michael S., Khanna, Kamal M., Stapleford, Kenneth A., Cresswell, Peter, Liu, Yue, Ding, Siyuan, Xie, Qi, Wang, Jun

“…Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engagement with immune cells, most express little, if any, of the…”
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A New Vaccine for Chikungunya Virus by Stapleford, Kenneth A, Mulligan, Mark J

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Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production by Martin, Marie-France, Bonaventure, Boris, McCray, Nia E, Peersen, Olve B, Rozen-Gagnon, Kathryn, Stapleford, Kenneth A

“…Alphaviruses encode an error-prone RNA-dependent RNA polymerase (RdRp), nsP4, required for genome synthesis, yet how the RdRp functions in the complete…”
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An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2 by Tada, Takuya, Fan, Chen, Chen, Jennifer S., Kaur, Ramanjit, Stapleford, Kenneth A., Gristick, Harry, Dcosta, Belinda M., Wilen, Craig B., Nimigean, Crina M., Landau, Nathaniel R.

“…Soluble forms of angiotensin-converting enzyme 2 (ACE2) have recently been shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions by Thannickal, Sara A, Battini, Leandro, Spector, Sophie N, Noval, Maria G, Álvarez, Diego E, Stapleford, Kenneth A

“…In a previous study to understand how the chikungunya virus (CHIKV) E1 glycoprotein β-strand c functions, we identified several attenuating variants at E1…”
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Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides by Cifuentes Kottkamp, Angelica, De Jesus, Elfie, Grande, Rebecca, Brown, Julia A, Jacobs, Adam R, Lim, Jean K, Stapleford, Kenneth A

“…Arthropod-borne viruses represent a significant public health threat worldwide, yet there are few antiviral therapies or prophylaxes targeting these pathogens…”
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Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic Potential by Stapleford, Kenneth A., Coffey, Lark L., Lay, Sreyrath, Bordería, Antonio V., Duong, Veasna, Isakov, Ofer, Rozen-Gagnon, Kathryn, Arias-Goeta, Camilo, Blanc, Hervé, Beaucourt, Stéphanie, Haliloğlu, Türkan, Schmitt, Christine, Bonne, Isabelle, Ben-Tal, Nir, Shomron, Noam, Failloux, Anna-Bella, Buchy, Philippe, Vignuzzi, Marco

“…The high replication and mutation rates of RNA viruses can result in the emergence of new epidemic variants. Thus, the ability to follow host-specific…”
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The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication by Li, Jie, Gui, Qi, Liang, Feng-Xia, Sall, Joseph, Zhang, Qingyue, Duan, Yatong, Dhabaria, Avantika, Askenazi, Manor, Ueberheide, Beatrix, Stapleford, Kenneth A, Pagano, Michele

“…Generation of virus-host protein-protein interactions (PPIs) maps may provide clues to uncover SARS-CoV-2-hijacked cellular processes. However, these PPIs maps…”
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The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition by Hattori, Takamitsu, Koide, Akiko, Noval, Maria G., Panchenko, Tatyana, Romero, Larizbeth A., Teng, Kai Wen, Tada, Takuya, Landau, Nathaniel R., Stapleford, Kenneth A., Koide, Shohei

“…[Display omitted] •Epitope analysis with a designed receptor-binding domain (RBD) mutant of Spike.•Patient antibodies dominantly bind regions outside the…”
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Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation by Rangel, Margarita V, McAllister, Nicole, Dancel-Manning, Kristen, Noval, Maria G, Silva, Laurie A, Stapleford, Kenneth A

“…Chikungunya virus (CHIKV) is a reemerging arthropod-borne alphavirus and a serious threat to human health. Therefore, efforts toward elucidating how this virus…”
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