Search Results - "Stanton, Bruce A."

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles by Koeppen, Katja, Hampton, Thomas H, Jarek, Michael, Scharfe, Maren, Gerber, Scott A, Mielcarz, Daniel W, Demers, Elora G, Dolben, Emily L, Hammond, John H, Hogan, Deborah A, Stanton, Bruce A

“…Bacterial outer membrane vesicle (OMV)-mediated delivery of proteins to host cells is an important mechanism of host-pathogen communication. Emerging evidence…”
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Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis by Li, Zhongyou, Stanton, Bruce A.

“…In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not…”
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Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles by Bomberger, Jennifer M, Maceachran, Daniel P, Coutermarsh, Bonita A, Ye, Siying, O'Toole, George A, Stanton, Bruce A

“…Bacteria use a variety of secreted virulence factors to manipulate host cells, thereby causing significant morbidity and mortality. We report a mechanism for…”
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Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease by Hogan, Deborah A, Willger, Sven D, Dolben, Emily L, Hampton, Thomas H, Stanton, Bruce A, Morrison, Hilary G, Sogin, Mitchell L, Czum, Julianna, Ashare, Alix

“…Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to irreversible damage. We sought to examine regional variation in the…”
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Tobramycin and FDA-Approved Iron Chelators Eliminate Pseudomonas aeruginosa Biofilms on Cystic Fibrosis Cells by Moreau-Marquis, Sophie, O'Toole, George A, Stanton, Bruce A

“…The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to account for the inability of current therapies to resolve bacterial…”
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Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles by Koeppen, Katja, Barnaby, Roxanna, Jackson, Angelyca A, Gerber, Scott A, Hogan, Deborah A, Stanton, Bruce A

“…Tobramycin is commonly used to treat Pseudomonas aeruginosa lung infections in patients with Cystic Fibrosis (CF). Tobramycin treatment leads to increased lung…”
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A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system by Bomberger, Jennifer M, Ye, Siying, Maceachran, Daniel P, Koeppen, Katja, Barnaby, Roxanna L, O'Toole, George A, Stanton, Bruce A

“…Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen chronically infecting the lungs of patients with chronic obstructive pulmonary disease…”
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The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells by Bomberger, Jennifer M., Barnaby, Roxanna L., Stanton, Bruce A.

“…The cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ABC transporter superfamily, is a cyclic AMP-regulated chloride channel and a…”
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Bacterial Outer Membrane Vesicles and Immune Modulation of the Host by Charpentier, Lily A, Dolben, Emily F, Hendricks, Matthew R, Hogan, Deborah A, Bomberger, Jennifer M, Stanton, Bruce A

“…This article reviews the role of outer membrane vesicles (OMVs) in mediating the interaction between Gram-negative bacteria and their human hosts. OMVs are…”
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In Vitro Analysis of Tobramycin-Treated Pseudomonas aeruginosa Biofilms on Cystic Fibrosis-Derived Airway Epithelial Cells by Anderson, Gregory G, Moreau-Marquis, Sophie, Stanton, Bruce A, O'Toole, George A

“…P. aeruginosa forms biofilms in the lungs of individuals with cystic fibrosis (CF); however, there have been no effective model systems for studying biofilm…”
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Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes by Heussler, Gary E, Cady, Kyle C, Koeppen, Katja, Bhuju, Sabin, Stanton, Bruce A, O'Toole, George A

“…The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (CRISPR/Cas) system is an adaptive immune system present in many…”
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Anr and Its Activation by PlcH Activity in Pseudomonas aeruginosa Host Colonization and Virulence by Jackson, Angelyca A, Gross, Maegan J, Daniels, Emily F, Hampton, Thomas H, Hammond, John H, Vallet-Gely, Isabelle, Dove, Simon L, Stanton, Bruce A, Hogan, Deborah A

“…Pseudomonas aeruginosa hemolytic phospholipase C (PlcH) degrades phosphatidylcholine (PC), an abundant lipid in cell membranes and lung surfactant. A ΔplcHR…”
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ESKAPE Act Plus: Pathway Activation Analysis for Bacterial Pathogens by Koeppen, Katja, Hampton, Thomas H, Neff, Samuel L, Stanton, Bruce A

“…The last 20 years have witnessed an explosion in publicly available gene expression and proteomic data and new tools to help researchers analyze these data…”
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Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa by Notch, Emily G, Goodale, Britton C, Barnaby, Roxanna, Coutermarsh, Bonita, Berwin, Brent, Taylor, Vivien F, Jackson, Brian P, Stanton, Bruce A

“…Arsenic is the number one contaminant of concern with regard to human health according to the World Health Organization. Epidemiological studies on Asian and…”
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Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability by Hampton, Thomas H, Thomas, Devin, van der Gast, Christopher, O'Toole, George A, Stanton, Bruce A

“…Microbial communities in the airways of persons with CF (pwCF) are variable, may include genera that are not typically associated with CF, and their…”
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Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes by Shaw, Joseph R, Hampton, Thomas H, King, Benjamin L, Whitehead, Andrew, Galvez, Fernando, Gross, Robert H, Keith, Nathan, Notch, Emily, Jung, Dawoon, Glaholt, Stephen P, Chen, Celia Y, Colbourne, John K, Stanton, Bruce A

“…Many organisms survive fluctuating and extreme environmental conditions by manifesting multiple distinct phenotypes during adulthood by means of developmental…”
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Pre-Analytical Handling Conditions and Small RNA Recovery from Urine for miRNA Profiling by Armstrong, David A., Dessaint, John A., Ringelberg, Carol S., Hazlett, Haley F., Howard, Louisa, Abdalla, Moemen A.K., Barnaby, Roxanna L., Stanton, Bruce A., Cervinski, Mark A., Ashare, Alix

“…There are currently no standardized protocols for pre-analytical handling of urine to best preserve small RNA for miRNA profiling studies. miRNA is an…”
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Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells by Stanton, Bruce A, Coutermarsh, Bonita, Barnaby, Roxanna, Hogan, Deborah

“…P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated…”
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Rocket-miR, a translational launchpad for miRNA-based antimicrobial drug development by Neff, Samuel L, Hampton, Thomas H, Koeppen, Katja, Sarkar, Sharanya, Latario, Casey J, Ross, Benjamin D, Stanton, Bruce A

“…Antimicrobial-resistant infections contribute to millions of deaths worldwide every year. In particular, the group of bacteria collectively known as ESKAPE (…”
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CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies by Neff, Samuel L., Hampton, Thomas H., Puerner, Charles, Cengher, Liviu, Doing, Georgia, Lee, Alexandra J., Koeppen, Katja, Cheung, Ambrose L., Hogan, Deborah A., Cramer, Robert A., Stanton, Bruce A.

“…Researchers studying cystic fibrosis (CF) pathogens have produced numerous RNA-seq datasets which are available in the gene expression omnibus (GEO). Although…”
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