Search Results - "Stanley, Pamela"

What Have We Learned from Glycosyltransferase Knockouts in Mice? by Stanley, Pamela

“…There are five major classes of glycan including N- and O-glycans, glycosaminoglycans, glycosphingolipids, and glycophosphatidylinositol anchors, all expressed…”
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Regulation of Notch signaling by glycosylation by Stanley, Pamela

“…Notch receptors are ∼300 kDa cell surface glycoproteins whose activation by Notch ligands regulates cell fate decisions in the metazoa. The extracellular…”
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Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis by Tanwar, Ankit, Stanley, Pamela

“…Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis…”
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EOGT and O -GlcNAc on secreted and membrane proteins by Varshney, Shweta, Stanley, Pamela

“…Here, we describe a recently discovered -GlcNAc transferase termed EOGT for EGF domain-specific -GlcNAc transferase. EOGT transfers GlcNAc (…”
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Author Correction: MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis by Biswas, Barnali, Batista, Frank, Sundaram, Subha, Stanley, Pamela

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Regulation of myeloid and lymphoid cell development by O-glycans on Notch by Stanley, Pamela, Tanwar, Ankit

“…Notch signaling NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand…”
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The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila by Müller, Reto, Jenny, Andreas, Stanley, Pamela

“…The O-GlcNAc transferase Eogt modifies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch. In this paper, we show that the…”
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EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1 by Nauman, Mohd, Varshney, Shweta, Choi, Jiahn, Augenlicht, Leonard H., Stanley, Pamela

“…Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans…”
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MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis by Biswas, Barnali, Batista, Frank, Sundaram, Subha, Stanley, Pamela

“…Mechanisms that regulate spermatogenesis in mice are important to define as they often apply to fertility in man. We previously showed that conditional…”
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Protein O-Fucosyltransferase 1 Is an Essential Component of Notch Signaling Pathways by Shi, Shaolin, Stanley, Pamela

“…Notch receptor signaling regulates cell growth and differentiation, and core components of Notch signaling pathways are conserved from Drosophila to humans…”
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The O-Fucose Glycan in the Ligand-Binding Domain of Notch1 Regulates Embryogenesis and T Cell Development by Ge, Changhui, Stanley, Pamela

“…Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1…”
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Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets by Alfaro, Joshua F, Gong, Cheng-Xin, Monroe, Matthew E, Aldrich, Joshua T, Clauss, Therese R. W, Purvine, Samuel O, Wang, Zihao, Camp, David G. II, Shabanowitz, Jeffrey, Stanley, Pamela, Hart, Gerald W, Hunt, Donald F, Yang, Feng, Smith, Richard D

“…O-linked N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification of Ser and Thr residues on cytosolic and nuclear proteins of higher…”
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Inhibition of Delta-induced Notch signaling using fucose analogs by Schneider, Michael, Kumar, Vivek, Nordstrøm, Lars Ulrik, Feng, Lei, Takeuchi, Hideyuki, Hao, Huilin, Luca, Vincent C, Garcia, K Christopher, Stanley, Pamela, Wu, Peng, Haltiwanger, Robert S

“…Protein O -fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O -fucose residues to its extracellular domain. Fucose analogs were identified that…”
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Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling by Stahl, Mark, Uemura, Kazuhide, Ge, Changhui, Shi, Shaolin, Tashima, Yuko, Stanley, Pamela

“…Mammalian Notch receptors contain 29–36 epidermal growth factor (EGF)-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an…”
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Roles for Golgi Glycans in Oogenesis and Spermatogenesis by Akintayo, Ayodele, Stanley, Pamela

“…Glycosylation of proteins by N- and O-glycans or glycosaminoglycans (GAGs) mostly begins in the endoplasmic reticulum and is further orchestrated in the Golgi…”
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O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals by Sawaguchi, Shogo, Varshney, Shweta, Ogawa, Mitsutaka, Sakaidani, Yuta, Yagi, Hirokazu, Takeshita, Kyosuke, Murohara, Toyoaki, Kato, Koichi, Sundaram, Subha, Stanley, Pamela, Okajima, Tetsuya

“…The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane…”
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Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity by North, Simon J., Huang, Hung-Hsiang, Sundaram, Subha, Jang-Lee, Jihye, Etienne, A. Tony, Trollope, Alana, Chalabi, Sara, Dell, Anne, Stanley, Pamela, Haslam, Stuart M.

“…Identifying biological roles for mammalian glycans and the pathways by which they are synthesized has been greatly facilitated by investigations of…”
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A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice by Varshney, Shweta, Wei, Hua-Xing, Batista, Frank, Nauman, Mohd, Sundaram, Subha, Siminovitch, Katherine, Tanwar, Ankit, Stanley, Pamela

“…Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at…”
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Galactose Differentially Modulates Lunatic and Manic Fringe Effects on Delta1-induced NOTCH Signaling by Hou, Xinghua, Tashima, Yuko, Stanley, Pamela

“…NOTCH signaling induced by Delta1 (DLL1) and Jagged1 (JAG1) NOTCH ligands is modulated by the β3N-acetylglucosaminyl transferase Fringe. LFNG (Lunatic Fringe)…”
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Deletion of Mgat2 in spermatogonia blocks spermatogenesis by Asmat, Mohd Shamoon, Zheng, Xiang Yu, Nauman, Mohd, Zheng, Deyou, Stanley, Pamela

“…Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the or gene leads to a…”
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