Search Results - "Stanko, Jason P."
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Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
Published in Molecular and cellular endocrinology (25-05-2009)“…The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing pregnancy loss, increased neonatal mortality,…”
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Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method
Published in Journal of visualized experiments (12-07-2017)“…An increasing number of studies are utilizing the rodent mammary gland as an endpoint for assessing the developmental toxicity of a chemical exposure. The…”
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Mammary Gland Development as a Sensitive End Point after Acute Prenatal Exposure to an Atrazine Metabolite Mixture in Female Long-Evans Rats
Published in Environmental health perspectives (01-04-2007)“…Background: Atrazine (ATR), a widely used chlorotriazine herbicide, inhibits a number of endocrine-dependent processes, including gonadotrophin surges and…”
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In vivo assessment of the capacity of androstenedione to masculinize female mosquitofish (Gambusia affinis) exposed through dietary and static renewal methods
Published in Environmental toxicology and chemistry (01-05-2007)“…In this study, we investigated the capacity of androstenedione to masculinize female mosquitofish. Previous studies have identified androstenedione in the…”
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Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium
Published in Toxicological sciences (28-07-2022)“…Abstract Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human…”
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An in vitro-in silico workflow for predicting renal clearance of PFAS
Published in Toxicology and applied pharmacology (01-08-2024)“…Per- and poly-fluoroalkyl substances (PFAS) have a wide range of elimination half-lives (days to years) in humans, thought to be in part due to variation in…”
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Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity
Published in Toxicological sciences (30-10-2023)“…Abstract Microphysiological systems are an emerging area of in vitro drug development, and their independent evaluation is important for wide adoption and use…”
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Gestational and Chronic Low-Dose PFOA Exposures and Mammary Gland Growth and Differentiation in Three Generations of CD-1 Mice
Published in Environmental health perspectives (01-08-2011)“…Background: Prenatal exposure to perfluorooctanoic acid (PFOA), a ubiquitous industrial surfactant, has been reported to delay mammary gland development in…”
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Application of Sholl analysis to quantify changes in growth and development in rat mammary gland whole mounts
Published in Reproductive toxicology (Elmsford, N.Y.) (01-07-2015)“…•A method was developed for quantitatively assessing rat mammary gland development.•The method allows for measuring branching density in 2D mammary whole mount…”
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Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low-Dose Developmental Effects and Internal Dosimetry
Published in Toxicological sciences (01-07-2011)“…Perfluorooctanoic acid (PFOA) is an environmental contaminant that causes adverse developmental effects in laboratory animals. To investigate the low-dose…”
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Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure
Published in Toxicologic pathology (01-10-2016)“…The potential of chemicals to alter susceptibility to mammary tumor formation is often assessed using a carcinogen-induced study design in various rat strains…”
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Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs
Published in Antimicrobial Agents and Chemotherapy (01-03-1998)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
Published in Reproductive toxicology (Elmsford, N.Y.) (01-07-2012)“…► We assess whether perfluorooctanoic acid (PFOA) is estrogenic or antiestrogenic. ► We use an immature mouse uterotrophic assay and histopathology. ► Uterine…”
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Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats
Published in Reproductive toxicology (Elmsford, N.Y.) (01-12-2010)“…The present study examines the postnatal reproductive development of male rats following prenatal exposure to an atrazine metabolite mixture (AMM) consisting…”
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Analysis of PFOA in dosed CD-1 mice. Part 2: Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups
Published in Reproductive toxicology (Elmsford, N.Y.) (01-06-2009)“…Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental…”
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Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures
Published in Reproductive toxicology (Elmsford, N.Y.) (01-06-2009)“…The adverse consequences of developmental exposures to perfluorooctanoic acid (PFOA) are established in mice, and include impaired development of the mammary…”
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Analysis of PFOA in dosed CD1 mice: Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pups
Published in Reproductive toxicology (Elmsford, N.Y.) (01-06-2009)“…The number of studies involving the analysis of perfluorooctanoic acid (PFOA) has increased recently because PFOA is routinely detected in human blood samples…”
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Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method
Published in Journal of visualized experiments (12-07-2017)Get full text
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P16—Developmental exposure of CD-1 mice to PFOA identifies the mammary gland as a low dose target tissue
Published in Reproductive toxicology (Elmsford, N.Y.) (01-07-2012)Get full text
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