Search Results - "Staniszewski, Kristine E"

Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg, Carina I, Staniszewski, Kristine E, Mensah, Kwame N, Matouschek, Andreas, Morimoto, Richard I

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Endowing Human Pancreatic Ribonuclease with Toxicity for Cancer Cells by Leland, P A, Staniszewski, K E, Kim, B M, Raines, R T

“…Onconase ® is an amphibian protein that is now in Phase III clinical trials as a cancer chemotherapeutic. Human pancreatic ribonuclease (RNase 1) is…”
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The Ribonucleolytic Activity of Angiogenin by Leland, Peter A, Staniszewski, Kristine E, Park, Chiwook, Kelemen, Bradley R, Raines, Ronald T

“…Angiogenin (ANG), a homologue of bovine pancreatic ribonuclease A (RNase A), promotes the growth of new blood vessels. The biological activity of ANG is…”
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A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease by Leland, Peter A., Staniszewski, Kristine E., Kim, Byung-Moon, Raines, Ronald T.

“…Onconase ® (ONC) is a homolog of ribonuclease A (RNase A) that has unusually high conformational stability and is toxic to human cancer cells in vitro and in…”
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Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg, Carina I, Staniszewski, Kristine E, Mensah, Kwame N, Matouschek, Andreas, Morimoto, Richard I

“…Accumulation of mutant proteins into misfolded species and aggregates is characteristic for diverse neurodegenerative diseases including the polyglutamine…”
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