Search Results - "Stanisçuaski Guterres, Silvia"
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Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials
Published in Molecules (Basel, Switzerland) (26-11-2019)“…Glioblastoma (GBM) is the most lethal form of brain tumor, being characterized by the rapid growth and invasion of the surrounding tissue. The current standard…”
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Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
Published in Pharmaceutics (15-03-2018)“…In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system,…”
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Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery
Published in Pharmaceutics (18-02-2019)“…Drug delivery to the brain represents a challenge, especially in the therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins,…”
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Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications
Published in Molecules (Basel, Switzerland) (07-07-2021)“…Bevacizumab (BCZ) is a recombinant humanized monoclonal antibody against the vascular endothelial growth factor, which is involved in the angiogenesis process…”
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The Anti-Arthritic Activity of Diclofenac Lipid-Core Nanocapsules: Stereological Analysis Showing More Protection of Deep Joint Components
Published in Molecules (Basel, Switzerland) (01-07-2023)“…Diclofenac is the most prescribed nonsteroidal anti-inflammatory drug worldwide and is used to relieve pain and inflammation in inflammatory arthritis…”
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Chitosan-Coated Lipid-Core Nanocapsules Functionalized with Gold-III and Bevacizumab Induced In Vitro Cytotoxicity against C6 Cell Line and In Vivo Potent Antiangiogenic Activity
Published in Pharmaceutical research (01-06-2020)“…Purpose Bevacizumab (BCZ) is a recombinant monoclonal antibody that inhibits the biological activity of the vascular endothelial growth factor, which has an…”
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Effect of nanocapsules containing docosahexaenoic acid in mice with chronic inflammation
Published in Biomedicine & pharmacotherapy (01-11-2023)“…Omega 3 fatty acids, such as docosahexaenoic acid (DHA) have been widely consumed as supplements to control chronic inflammation. Nanocapsules containing DHA…”
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Melatonin delivery by nanocapsules during in vitro bovine oocyte maturation decreased the reactive oxygen species of oocytes and embryos
Published in Reproductive toxicology (Elmsford, N.Y.) (01-08-2016)“…[Display omitted] •Supplementation of Mel-LNC during in vitro Maturation increases cleavage and blastocyst rates.•Decrease of ROS levels and apoptotic cell…”
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Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model
Published in PloS one (01-06-2016)“…Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge…”
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Chicken embryo model for in vivo acute toxicological and antitumor efficacy evaluation of lipid nanocarrier containing doxorubicin
Published in International journal of pharmaceutics: X (15-12-2023)“…Nanoencapsulation of chemotherapeutics, including doxorubicin, can endow the formulations with unique properties, such as a decrease in adverse effects and…”
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Toltrazuril-Loaded Polymeric Nanocapsules as a Promising Approach for the Preventive Control of Coccidiosis in Poultry
Published in Pharmaceutics (10-02-2022)“…Coccidiosis is a disease caused by intracellular protozoan parasites of the genus that affect the intestinal tract of poultry. However, strain resistance and…”
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The Production, Characterization, and the Stability of Carotenoids Loaded in Lipid-Core Nanocapsules
Published in Food and bioprocess technology (01-07-2016)“…The use of carotenoids in foods is limited due to their poor solubility in water-rich matrices, and the nanoencapsulation emerges as an alternative to allowing…”
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Nanoformulation Shows Cytotoxicity against Glioblastoma Cell Lines and Antiangiogenic Activity in Chicken Chorioallantoic Membrane
Published in Pharmaceutics (11-06-2021)“…Glioblastoma (GB) is a histological and genetically heterogeneous brain tumor that is highly proliferative and vascularized. The prognosis is poor with…”
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scFv-Anti-LDL(-)-Metal-Complex Multi-Wall Functionalized-Nanocapsules as a Promising Tool for the Prevention of Atherosclerosis Progression
Published in Frontiers in medicine (20-04-2021)“…Atherosclerosis can be originated from the accumulation of modified cholesterol-rich lipoproteins in the arterial wall. The electronegative LDL, LDL(-), plays…”
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Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
Published in Química nova (2008)“…The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best…”
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Incorporation of zeaxanthin nanoparticles in yogurt: Influence on physicochemical properties, carotenoid stability and sensory analysis
Published in Food chemistry (15-12-2019)“…•Zea-NP and Zea-NE were incorporated in yogurt.•The yogurt with Zea-NP showed higher carotenoid content at the end of storage time.•Zeaxanthin bioaccessibility…”
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Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
Published in Química Nova (2012)“…A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water…”
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Folic acid-doxorubicin polymeric nanocapsules: A promising formulation for the treatment of triple-negative breast cancer
Published in European journal of pharmaceutical sciences (01-10-2021)“…•LNC-L-CS-Zn2+-DOX-FA reduced cell viability, migration, and colony formation1•qRT-PCR analysis showed that LNC-L-CS-Zn2+-DOX-FA induced apoptosis of…”
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Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
Published in International journal of nanomedicine (01-07-2019)“…Resveratrol (RSV) has attracted interest as an alternative drug for the treatment of acute lung injury (ALI) and other pulmonary diseases, but its poor oral…”
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Spray-dried raloxifene submicron particles for pulmonary delivery: Development and in vivo pharmacokinetic evaluation in rats
Published in International journal of pharmaceutics (30-07-2020)“…[Display omitted] Raloxifene hydrochloride (RH) is a selective oestrogen receptor modulator used for the treatment of osteoporosis. Even though 60% of an oral…”
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