Search Results - "Stanifer, Megan L"

Differential Regulation of Type I and Type III Interferon Signaling by Stanifer, Megan L, Pervolaraki, Kalliopi, Boulant, Steeve

“…Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by…”
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SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography by Klein, Steffen, Cortese, Mirko, Winter, Sophie L., Wachsmuth-Melm, Moritz, Neufeldt, Christopher J., Cerikan, Berati, Stanifer, Megan L., Boulant, Steeve, Bartenschlager, Ralf, Chlanda, Petr

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID19 pandemic, is a highly pathogenic β-coronavirus. As other…”
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Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces by Stanifer, Megan L, Guo, Cuncai, Doldan, Patricio, Boulant, Steeve

“…Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells…”
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Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells by Stanifer, Megan L., Kee, Carmon, Cortese, Mirko, Zumaran, Camila Metz, Triana, Sergio, Mukenhirn, Markus, Kraeusslich, Hans-Georg, Alexandrov, Theodore, Bartenschlager, Ralf, Boulant, Steeve

“…Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an unprecedented worldwide health problem that requires concerted and global approaches…”
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Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut by Triana, Sergio, Metz‐Zumaran, Camila, Ramirez, Carlos, Kee, Carmon, Doldan, Patricio, Shahraz, Mohammed, Schraivogel, Daniel, Gschwind, Andreas R, Sharma, Ashwini K, Steinmetz, Lars M, Herrmann, Carl, Alexandrov, Theodore, Boulant, Steeve, Stanifer, Megan L

“…Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology. However, despite the mounting evidence about SARS‐CoV‐2 infecting the human…”
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Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance by Pervolaraki, Kalliopi, Rastgou Talemi, Soheil, Albrecht, Dorothee, Bormann, Felix, Bamford, Connor, Mendoza, Juan L, Garcia, K Christopher, McLauchlan, John, Höfer, Thomas, Stanifer, Megan L, Boulant, Steeve

“…It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on…”
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Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection by Petitjean, Simon J. L., Chen, Wenzhang, Koehler, Melanie, Jimmidi, Ravikumar, Yang, Jinsung, Mohammed, Danahe, Juniku, Blinera, Stanifer, Megan L., Boulant, Steeve, Vincent, Stéphane P., Alsteens, David

“…The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent need to better understand the molecular details of the virus binding to…”
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Mechanism of membrane fusion induced by vesicular stomatitis virus G protein by Kim, Irene S., Jenni, Simon, Stanifer, Megan L., Roth, Eatai, Whelan, Sean P. J., van Oijen, Antoine M., Harrison, Stephen C.

“…The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane…”
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Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions by Stanifer, Megan L, Karst, Stephanie M, Boulant, Steeve

“…As the largest mucosal surface, the gastrointestinal (GI) tract plays a key role in protecting the host against pathogen infections. It is a first line of…”
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Single‐cell transcriptomics reveals immune response of intestinal cell types to viral infection by Triana, Sergio, Stanifer, Megan L, Metz‐Zumaran, Camila, Shahraz, Mohammed, Mukenhirn, Markus, Kee, Carmon, Serger, Clara, Koschny, Ronald, Ordoñez‐Rueda, Diana, Paulsen, Malte, Benes, Vladimir, Boulant, Steeve, Alexandrov, Theodore

“…Human intestinal epithelial cells form a primary barrier protecting us from pathogens, yet only limited knowledge is available about individual contribution of…”
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Extended methods for spatial cell classification with DBSCAN-CellX by Küchenhoff, Leonie, Lukas, Pascal, Metz-Zumaran, Camila, Rothhaar, Paul, Ruggieri, Alessia, Lohmann, Volker, Höfer, Thomas, Stanifer, Megan L., Boulant, Steeve, Talemi, Soheil Rastgou, Graw, Frederik

“…Local cell densities and positioning within cellular monolayers and stratified epithelia have important implications for cell interactions and the…”
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Influence of cell type specific infectivity and tissue composition on SARS-CoV-2 infection dynamics within human airway epithelium by Raach, Benjamin, Bundgaard, Nils, Haase, Marika J, Starruß, Jörn, Sotillo, Rocio, Stanifer, Megan L, Graw, Frederik

“…Human airway epithelium (HAE) represents the primary site of viral infection for SARS-CoV-2. Comprising different cell populations, a lot of research has been…”
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Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut by Pervolaraki, Kalliopi, Stanifer, Megan L, Münchau, Stephanie, Renn, Lynnsey A, Albrecht, Dorothee, Kurzhals, Stefan, Senís, Elena, Grimm, Dirk, Schröder-Braunstein, Jutta, Rabin, Ronald L, Boulant, Steeve

“…Intestinal epithelial cells (IECs) are constantly exposed to commensal flora and pathogen challenges. How IECs regulate their innate immune response to…”
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Author Correction: Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection by Petitjean, Simon J. L., Chen, Wenzhang, Koehler, Melanie, Jimmidi, Ravikumar, Yang, Jinsung, Mohammed, Danahe, Juniku, Blinera, Stanifer, Megan L., Boulant, Steeve, Vincent, Stéphane P., Alsteens, David

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The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters by Shytaj, Iart Luca, Fares, Mohamed, Gallucci, Lara, Lucic, Bojana, Tolba, Mahmoud M, Zimmermann, Liv, Adler, Julia M, Xing, Na, Bushe, Judith, Gruber, Achim D, Ambiel, Ina, Taha Ayoub, Ahmed, Cortese, Mirko, Neufeldt, Christopher J, Stolp, Bettina, Sobhy, Mohamed Hossam, Fathy, Moustafa, Zhao, Min, Laketa, Vibor, Diaz, Ricardo Sobhie, Sutton, Richard E, Chlanda, Petr, Boulant, Steeve, Bartenschlager, Ralf, Stanifer, Megan L, Fackler, Oliver T, Trimpert, Jakob, Savarino, Andrea, Lusic, Marina

“…Combinations of direct-acting antivirals are needed to minimize drug resistance mutations and stably suppress replication of RNA viruses. Currently, there are…”
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The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity by Ramirez Alvarez, Carlos, Kee, Carmon, Sharma, Ashwini Kumar, Thomas, Leonie, Schmidt, Florian I, Stanifer, Megan L, Boulant, Steeve, Herrmann, Carl

“…COVID-19 outbreak is the biggest threat to human health in recent history. Currently, there are over 1.5 million related deaths and 75 million people infected…”
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5 by Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans…”
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USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING by Karlowitz, Rebekka, Stanifer, Megan L., Roedig, Jens, Andrieux, Geoffroy, Bojkova, Denisa, Bechtel, Marco, Smith, Sonja, Kowald, Lisa, Schubert, Ralf, Boerries, Melanie, Cinatl, Jindrich, Boulant, Steeve, van Wijk, Sjoerd J. L.

“…Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19…”
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Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection by Tekes, Gergely, Ehmann, Rosina, Boulant, Steeve, Stanifer, Megan L

“…Feline coronaviruses (FCoVs) infect both wild and domestic cat populations world-wide. FCoVs present as two main biotypes: the mild feline enteric coronavirus…”
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Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins by Guo, Cuncai, Reuss, Dorothee, Coey, Jonathon D, Sukumar, Swathi, Lang, Benjamin, McLauchlan, John, Boulant, Steeve, Stanifer, Megan L, Bamford, Connor G G

“…Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver,…”
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