The isolated perfused working mouse heart system

The isolated perfused working mouse heart system

Study of cardioactive agents in vivo is complicated by neurohormonal influences and variations in loading conditions. The working mouse heart perfusion system allows for the ex vivo direct measurement of cardiac metabolism and function, and responses to drugs and hormones, under defined conditions....

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Bibliographic Details
Published in:2009 IEEE 35th Annual Northeast Bioengineering Conference pp. 1 - 2
Main Authors: Dunn, M.E., Stanhewicz, A.E., Manfredi, T.G., Cosmas, A.C., Rodgers, R.L., Vetter, F.J.
Format: Conference Proceeding
Language:English
Published: IEEE 01-04-2009
Subjects:
Biochemistry
Cardiology
Catheters
Drugs
Heart rate
In vivo
Mice
Myocardium
Oxidation
Volume measurement
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Summary:Study of cardioactive agents in vivo is complicated by neurohormonal influences and variations in loading conditions. The working mouse heart perfusion system allows for the ex vivo direct measurement of cardiac metabolism and function, and responses to drugs and hormones, under defined conditions. Myocardial pressure and volume measurements are obtained using a micro-tip catheter inserted into the left ventricular chamber. Direct and derived functional data include heart rate (HR), cardiac output (CO), end systolic pressure (ESP), end diastolic pressure (EDP), end systolic volume (ESV), end diastolic volume (EDV), stroke volume (SV), and ejection fraction (EF). Metabolic data include rates of glycolysis, glucose oxidation, and fatty acid oxidation. The mouse serves as an ideal model for evaluation of the pharmacology and toxicity of novel cardioactive therapeutics due to its rapid reproduction, low cost, and relevance to human physiology.
ISBN:9781424443628
1424443628
ISSN:2160-6986
2160-7028
DOI:10.1109/NEBC.2009.4967760