Search Results - "Stangherlin, Alessandra"

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock by Edgar, Rachel S., Stangherlin, Alessandra, Nagy, Andras D., Nicoll, Michael P., Efstathiou, Stacey, O’Neill, John S., Reddy, Akhilesh B.

“…Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic,…”
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Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia by Hayter, Edward A., Wehrens, Sophie M. T., Van Dongen, Hans P. A., Stangherlin, Alessandra, Gaddameedhi, Shobhan, Crooks, Elena, Barron, Nichola J., Venetucci, Luigi A., O’Neill, John S., Brown, Timothy M., Skene, Debra J., Trafford, Andrew W., Bechtold, David A.

“…Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we…”
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Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology by Stangherlin, Alessandra, Watson, Joseph L., Wong, David C. S., Barbiero, Silvia, Zeng, Aiwei, Seinkmane, Estere, Chew, Sew Peak, Beale, Andrew D., Hayter, Edward A., Guna, Alina, Inglis, Alison J., Putker, Marrit, Bartolami, Eline, Matile, Stefan, Lequeux, Nicolas, Pons, Thomas, Day, Jason, van Ooijen, Gerben, Voorhees, Rebecca M., Bechtold, David A., Derivery, Emmanuel, Edgar, Rachel S., Newham, Peter, O’Neill, John S.

“…Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to…”
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The Pentose Phosphate Pathway Regulates the Circadian Clock by Rey, Guillaume, Valekunja, Utham K., Feeney, Kevin A., Wulund, Lisa, Milev, Nikolay B., Stangherlin, Alessandra, Ansel-Bollepalli, Laura, Velagapudi, Vidya, O’Neill, John S., Reddy, Akhilesh B.

“…The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on…”
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PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling by Monterisi, Stefania, Lobo, Miguel J, Livie, Craig, Castle, John C, Weinberger, Michael, Baillie, George, Surdo, Nicoletta C, Musheshe, Nshunge, Stangherlin, Alessandra, Gottlieb, Eyal, Maizels, Rory, Bortolozzi, Mario, Micaroni, Massimo, Zaccolo, Manuela

“…cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading…”
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Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2 by Zoccarato, Anna, Surdo, Nicoletta C, Aronsen, Jan M, Fields, Laura A, Mancuso, Luisa, Dodoni, Giuliano, Stangherlin, Alessandra, Livie, Craig, Jiang, He, Sin, Yuan Yan, Gesellchen, Frank, Terrin, Anna, Baillie, George S, Nicklin, Stuart A, Graham, Delyth, Szabo-Fresnais, Nicolas, Krall, Judith, Vandeput, Fabrice, Movsesian, Matthew, Furlan, Leonardo, Corsetti, Veronica, Hamilton, Graham, Lefkimmiatis, Konstantinos, Sjaastad, Ivar, Zaccolo, Manuela

“…RATIONALE:Chronic elevation of 3′-5′-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However,…”
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Author Correction: Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia by Hayter, Edward A., Wehrens, Sophie M. T., Van Dongen, Hans P. A., Stangherlin, Alessandra, Gaddameedhi, Shobhan, Crooks, Elena, Barron, Nichola J., Venetucci, Luigi A., O’Neill, John S., Brown, Timothy M., Skene, Debra J., Trafford, Andrew W., Bechtold, David A.

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Publisher Correction: Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology by Stangherlin, Alessandra, Watson, Joseph L., Wong, David C. S., Barbiero, Silvia, Zeng, Aiwei, Seinkmane, Estere, Chew, Sew Peak, Beale, Andrew D., Hayter, Edward A., Guna, Alina, Inglis, Alison J., Putker, Marrit, Bartolami, Eline, Matile, Stefan, Lequeux, Nicolas, Pons, Thomas, Day, Jason, van Ooijen, Gerben, Voorhees, Rebecca M., Bechtold, David A., Derivery, Emmanuel, Edgar, Rachel S., Newham, Peter, O’Neill, John S.

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cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes by Stangherlin, Alessandra, Gesellchen, Frank, Zoccarato, Anna, Terrin, Anna, Fields, Laura Ashley, Berrera, Marco, Surdo, Nicoletta Concetta, Craig, Margaret Anne, Smith, Godfrey, Hamilton, Graham, Zaccolo, Manuela

“…RATIONALE:cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated…”
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Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms by Kay, Holly, Grünewald, Ellen, Feord, Helen K., Gil, Sergio, Peak-Chew, Sew Y., Stangherlin, Alessandra, O’Neill, John S., van Ooijen, Gerben

“…The cellular landscape changes dramatically over the course of a 24 h day. The proteome responds directly to daily environmental cycles and is additionally…”
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PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome by Terrin, Anna, Monterisi, Stefania, Stangherlin, Alessandra, Zoccarato, Anna, Koschinski, Andreas, Surdo, Nicoletta C, Mongillo, Marco, Sawa, Akira, Jordanides, Niove E, Mountford, Joanne C, Zaccolo, Manuela

“…Previous work has shown that the protein kinase A (PKA)-regulated phosphodiesterase (PDE) 4D3 binds to A kinase-anchoring proteins (AKAPs). One such protein,…”
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Ion dynamics and the regulation of circadian cellular physiology by Stangherlin, Alessandra

“…Circadian rhythms in physiology and behavior allow organisms to anticipate the daily environmental changes imposed by the rotation of our planet around its…”
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Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system by Stangherlin, Alessandra, Zaccolo, Manuela

“…Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5'-AMP and critically regulate the intensity and the…”
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Regulation of Circadian Clocks by Redox Homeostasis by Stangherlin, Alessandra, Reddy, Akhilesh B.

“…Living organisms possess biological clocks that resonate with environmental cycles in light, temperature, and food availability. Recently, circadian…”
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Relax: It’s Not All About Degradation by Stangherlin, Alessandra, Zoccarato, Anna

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Circadian rhythms in the absence of the clock gene Bmal1 by Ray, Sandipan, Valekunja, Utham K, Stangherlin, Alessandra, Howell, Steven A, Snijders, Ambrosius P, Damodaran, Gopinath, Reddy, Akhilesh B

“…Circadian (~24 hour) clocks have a fundamental role in regulating daily physiology. The transcription factor BMAL1 is a principal driver of a molecular clock…”
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cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function by Stangherlin, Alessandra, Zaccolo, Manuela

“…cAMP and cGMP signalling pathways are common targets in the pharmacological treatment of heart failure, and often drugs that modulate the level of these second…”
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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time by Crosby, Priya, Hamnett, Ryan, Putker, Marrit, Hoyle, Nathaniel P., Reed, Martin, Karam, Carolyn J., Maywood, Elizabeth S., Stangherlin, Alessandra, Chesham, Johanna E., Hayter, Edward A., Rosenbrier-Ribeiro, Lyn, Newham, Peter, Clevers, Hans, Bechtold, David A., O’Neill, John S.

“…In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and…”
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Signal Transduction: Magnesium Manifests as a Second Messenger by Stangherlin, Alessandra, O’Neill, John S.

“…Mg2+ is an essential ion for the cell but whether it can act as a bona fide second messenger has long been questioned. A recent study supports this hypothesis…”
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Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis in Circadian Biology by Stangherlin, Alessandra, Day, Jason, O'Neill, John

“…Inductively coupled plasma mass spectrometry (ICP-MS) is a sensitive instrumental analysis technique used for multielemental and isotopic determination. Here…”
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