Search Results - "Stanger, Matthew"

Mechanism of Single-Stranded DNA Activation of Recombinase Intein Splicing by Lennon, Christopher W, Stanger, Matthew J, Belfort, Marlene

“…Inteins, or intervening proteins, are mobile genetic elements translated within host polypeptides and removed through protein splicing. This self-catalyzed…”
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Protein splicing of a recombinase intein induced by ssDNA and DNA damage by Lennon, Christopher W, Stanger, Matthew, Belfort, Marlene

“…Inteins (or protein introns) autocatalytically excise themselves through protein splicing. We challenge the long-considered notion that inteins are merely…”
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SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses by Topilina, Natalya I, Green, Cathleen M, Jayachandran, Pradeepa, Kelley, Danielle S, Stanger, Matthew J, Piazza, Carol Lyn, Nayak, Sasmita, Belfort, Marlene

“…Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have inteins inserted into several important genes, including those…”
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Conditional Protein Splicing Switch in Hyperthermophiles through an Intein-Extein Partnership by Lennon, Christopher W, Stanger, Matthew, Banavali, Nilesh K, Belfort, Marlene

“…Inteins are intervening proteins that undergo an autocatalytic splicing reaction that ligates flanking host protein sequences termed exteins. Some…”
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Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications by Callahan, Brian P, Topilina, Natalya I, Stanger, Matthew J, Van Roey, Patrick, Belfort, Marlene

“…An intein controlled by redox in bacteria is created by engineering a disulfide bond between the catalytic cysteine residue and the flanking polypeptide. A…”
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Conditional DnaB Protein Splicing Is Reversibly Inhibited by Zinc in Mycobacteria by Woods, Daniel, Vangaveti, Sweta, Egbanum, Ikechukwu, Sweeney, Allison M, Li, Zhong, Bacot-Davis, Valjean, LeSassier, Danielle S, Stanger, Matthew, Hardison, Gabrielle E, Li, Hongmin, Belfort, Marlene, Lennon, Christopher W

“…Inteins, as posttranslational regulatory elements, can tune protein function to environmental changes by conditional protein splicing (CPS). Translated as…”
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Protease Activation of Split Green Fluorescent Protein by Callahan, Brian P., Stanger, Matthew J., Belfort, Marlene

“…Cut and glow: Site‐specific proteolysis triggers the assembly of green fluorescent protein fragments, providing a novel reporter of protease activity in vitro…”
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Coincidence of Cleavage Sites of Intron Endonuclease I-TevI and Critical Sequences of the Host Thymidylate Synthase Gene by Edgell, David R., Stanger, Matthew J., Belfort, Marlene

“…To maximize spread of their host intron or intein, many homing endonucleases recognize nucleotides that code for important and conserved amino acid residues of…”
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Homing endonuclease I-TevIII: dimerization as a means to a double-strand break by Robbins, Justin B, Stapleton, Michelle, Stanger, Matthew J, Smith, Dorie, Dansereau, John T, Derbyshire, Victoria, Belfort, Marlene

“…Homing endonucleases are unusual enzymes, capable of recognizing lengthy DNA sequences and cleaving site-specifically within genomes. Many homing endonucleases…”
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Localization, mobility and fidelity of retrotransposed Group II introns in rRNA genes by Conlan, Lori H., Stanger, Matthew J., Ichiyanagi, Kenji, Belfort, Marlene

“…We previously showed that the group II Lactococcus lactis Ll.LtrB intron could retrotranspose into ectopic locations on the genome of its native host. Two…”
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Importance of a Single Base Pair for Discrimination between Intron-Containing and Intronless Alleles by Endonuclease I-BmoI by Edgell, David R., Stanger, Matthew J., Belfort, Marlene

“…Homing endonucleases initiate mobility of their host group I introns by binding to and cleaving lengthy recognition sequences that are typically centered on…”
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Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor by Belfort, Marlene, Edgell, David R, Derbyshire, Victoria, Roey, Patrick Van, LaBonne, Stephen, Stanger, Matthew J, Li, Zhong, Boyd, Thomas M, Shub, David A

“…Customary binding sites of intron-encoded homing endonucleases lie within cognate intronless alleles, at the so-called homing sites. Here, we describe a novel,…”
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Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing by Topilina, Natalya I, Novikova, Olga, Stanger, Matthew, Banavali, Nilesh K, Belfort, Marlene

“…Post-translational control based on an environmentally sensitive intervening intein sequence is described. Inteins are invasive genetic elements that…”
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A redox trap to augment the intein toolbox by Callahan, Brian P., Stanger, Matthew, Belfort, Marlene

“…The unregulated activity of inteins during expression and consequent side reactions during work‐up limits their widespread use in biotechnology and chemical…”
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SufB intein ofMycobacterium tuberculosisas a sensor for oxidative and nitrosative stresses by Topilina, Natalya I., Green, Cathleen M., Jayachandran, Pradeepa, Kelley, Danielle S., Stanger, Matthew J., Piazza, Carol Lyn, Nayak, Sasmita, Belfort, Marlene

“…Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have inteins inserted into several important genes, including those…”
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Cut and glow: Protease activation of split green fluorescent protein by Callahan, Brian P., Stanger, Matthew J., Belfort, Marlene

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Disulfide engineering catches a self‐splicing intein in a redox trap by Callahan, Brian, Topilina, Natalya, Stanger, Matthew, Van Roey, Patrick, Belfort, Marlene

“…Inteins are autocatalytic proteins with broad biotechnological appeal that self‐splice from internal positions of precursor polypeptides in all domains of…”
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Variation at the major histocompatibility complex in Savannah sparrows by Freeman-Gallant, Corey R., Johnson, Elizabeth M., Saponara, Fiorella, Stanger, Matthew

“…The class I and class II genes of the major histocompatibility complex (Mhc) encode dimeric glycoproteins responsible for eliciting the adaptive immune…”
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