Search Results - "Stange, Eduard"

An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease by Wehkamp, Jan, Stange, Eduard F

“…The Paneth cells reside in the small intestine at the bottom of the crypts of Lieberkühn, intermingled with stem cells, and provide a niche for their neighbors…”
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Intestinal barrier in inflammatory bowel disease by Antoni, Lena, Nuding, Sabine, Wehkamp, Jan, Stange, Eduard F

“…A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal…”
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Microbiota and mucosal defense in IBD: an update by Stange, Eduard F, Schroeder, Bjoern O

“…: Inflammatory bowel diseases (IBD) are on the rise worldwide. This review covers the current concepts of the etiology of Crohn´s disease and ulcerative…”
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Twenty‐five years of biologicals in IBD: What´s all the hype about? by Herrlinger, Klaus R., Stange, Eduard F.

“…Twenty‐five years ago the field was revolutionized by the introduction of infliximab as the first hybrid anti‐TNF‐antibody. Subsequently, other humanized…”
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Dysbiosis in inflammatory bowel diseases: egg, not chicken by Stange, Eduard F

“…There is agreement that inflammatory bowel diseases are, both in terms of species composition and function, associated with an altered intestinal microbiome…”
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Inflammatory Bowel Disease by Wehkamp, Jan, Götz, Martin, Herrlinger, Klaus, Steurer, Wolfgang, Stange, Eduard F

“…Inflammatory bowel diseases are common in Europe, with prevalences as high as 1 in 198 persons (ulcerative colitis) and 1 in 310 persons (Crohn's disease)…”
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Ulcerative colitis—Maintanance of Remission With the Probiotic Escherichia coli Strain Nissle 1917 by Stange, Eduard F., von Bünau, Rudolf, Erhardt, Andreas

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Synergistic effects of antimicrobial peptides and antibiotics against Clostridium difficile by Nuding, Sabine, Frasch, Tina, Schaller, Martin, Stange, Eduard F, Zabel, Lutz T

“…Accelerating rates of health care-associated infections caused by Clostridium difficile, with increasing recurrence and rising antibiotic resistance rates,…”
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Inflammatory bowel disease: an impaired barrier disease by Jäger, Simon, Stange, Eduard F., Wehkamp, Jan

“…Background The intestinal barrier is a delicate structure composed of a single layer of epithelial cells, the mucus, commensal bacteria, immune cells, and…”
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Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1 by Schroeder, Bjoern O., Wu, Zhihong, Nuding, Sabine, Groscurth, Sandra, Marcinowski, Moritz, Beisner, Julia, Buchner, Johannes, Schaller, Martin, Stange, Eduard F., Wehkamp, Jan

“…Human β-defensin 1 shows its true colours Defensins are key effector molecules of innate immunity, protecting the host from infectious microbes and shaping the…”
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Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense by Teltschik, Zora, Wiest, Reiner, Beisner, Julia, Nuding, Sabine, Hofmann, Claudia, Schoelmerich, Juergen, Bevins, Charles L., Stange, Eduard F., Wehkamp, Jan

“…Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota,…”
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Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo by Becker, Svetlana, Oelschlaeger, Tobias A, Wullaert, Andy, Vlantis, Katerina, Pasparakis, Manolis, Wehkamp, Jan, Stange, Eduard F, Gersemann, Michael

“…The human colon harbours a plethora of bacteria known to broadly impact on mucosal metabolism and function and thought to be involved in inflammatory bowel…”
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Paneth's disease by Wehkamp, Jan, Stange, Eduard F.

“…A correction notice has been published, see: https://doi.org/10.1093/ecco-jcc/jjac104 In about 70% of patients Crohn's disease (CD) affects the small…”
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Improvement of a 'Leaky' Intestinal Barrier by Stange, Eduard F

“…In Crohn's disease, the mucus layer appears to be defective in terms of low defensin levels and lack of antibacterial activity. These deficiencies actually…”
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Recent advances and emerging therapies in the non-surgical management of ulcerative colitis [version 1; peer review: 3 approved] by Wehkamp, Jan, Stange, Eduard F

“…The so-called "biologicals" (monoclonal antibodies to various inflammatory targets like tumor necrosis factor or integrins) have revolutionized the treatment…”
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Extraintestinal manifestations and complications in inflammatory bowel diseases by Rothfuss, Katja S, Stange, Eduard F, Herrlinger, Klaus R

“…Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that often involve organs other than those of the…”
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Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin by Schlee, Miriam, Wehkamp, Jan, Altenhoefer, Artur, Oelschlaeger, Tobias A, Stange, Eduard F, Fellermann, Klaus

“…Human β-defensin 2 (hBD-2) is an inducible antimicrobial peptide synthesized by the epithelium to counteract bacterial adherence and invasion. Proinflammatory…”
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A new kid on the budesonide block by Stange, Eduard F

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Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis by Koeninger, Louis, Armbruster, Nicole S, Brinch, Karoline Sidelmann, Kjaerulf, Søren, Andersen, Birgitte, Langnau, Carolin, Autenrieth, Stella E, Schneidawind, Dominik, Stange, Eduard F, Malek, Nisar P, Nordkild, Peter, Jensen, Benjamin A H, Wehkamp, Jan

“…Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial…”
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Crohn’s disease-derived monocytes fail to induce Paneth cell defensins by Courth, Lioba F., Ostaff, Maureen J., Mailänder-Sánchez, Daniela, Malek, Nisar P., Stange, Eduard F., Wehkamp, Jan

“…Crohn’s disease (CD) is associated with a multitude of genetic defects, many of which likely affect Paneth cell function. Paneth cells reside in the small…”
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