Search Results - "Standing, JF"

Poor Formulation Information in Published Pediatric Drug Trials by Standing, Joseph F, Khaki, Zahra F, Wong, Ian C. K

“…The International Conference on Harmonisation Steering Committee recommends that appropriate formulations be used in pediatric drug trials. However, a lack of…”
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Fentanyl dosage for preterm infants suggested by a pharmacokinetic, -dynamic, and -genetic model by Bardol, Maddlie, Norman, Elisabeth, Lagercrantz, Hugo, Fellman, Vineta, Standing, Joseph F

“…Fentanyl is commonly administered for procedural pain management in preterm infants, but target concentrations have not yet been defined. To investigate…”
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Current knowledge, challenges and innovations in developmental pharmacology: A combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper by Smits, Anne, Annaert, Pieter, Cavallaro, Giacomo, De Cock, Pieter A. J. G., Wildt, Saskia N., Kindblom, Jenny M., Lagler, Florian B., Moreno, Carmen, Pokorna, Paula, Schreuder, Michiel F., Standing, Joseph F., Turner, Mark A., Vitiello, Benedetto, Zhao, Wei, Weingberg, Annelie‐Martina, Willmann, Raffaella, Anker, John, Allegaert, Karel

“…Developmental pharmacology describes the impact of maturation on drug disposition (pharmacokinetics, PK) and drug effects (pharmacodynamics, PD) throughout the…”
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Paediatric formulations—Getting to the heart of the problem by Standing, Joseph F., Tuleu, Catherine

“…Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules…”
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A2.1 A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital by Kwok, M, Booth, J, Konstanty, P, Standing, JF, Irwin, AD

“…BackgroundThe capacity to accurately measure and report antimicrobial consumption is an essential element of antimicrobial stewardship (AMS). Though days of…”
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Predicting CD4 T‐Cell Reconstitution Following Pediatric Hematopoietic Stem Cell Transplantation by Hoare, RL, Veys, P, Klein, N, Callard, R, Standing, JF

“…Hematopoietic stem cell transplantation (HSCT) is an increasingly common treatment for children with a range of hematological disorders. Conditioning with…”
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P74 Rituximab effect on B cell depletion in paediatric patients with autoimmune diseases: a retrospective dose-response analysis of an observational study by Pan, S, Yu, H, Surti, A, Cheng, I, Marks, SD, Brogan, PA, Eleftheriou, D, Standing, JF

“…BackgroundRituximab is a chimeric IgG1 monoclonal antibody that depletes B cells for the treatment of several conditions including autoimmune diseases. It is…”
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G394 Optimisation of vancomycin dosing regimen in newborns by performing a population pharmacokinetic analysis of prospectively collected data by Gunaratnam, F, Germovsek, E, Basquet, F Bossacoma, Pereira, S, Standing, JF, Sinha, AK

“…BackgroundVancomycin is a commonly used antimicrobial to treat hospital acquired infections in neonates. Although both intermittent and continuous dosing…”
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Differential susceptibility to tetracycline, oxytetracycline and doxycycline of the calf pathogens Mannheimia haemolytica and Pasteurella multocida in three growth media by Mead, Andrew, Lees, Peter, Mitchell, John, Rycroft, Andrew, Standing, Joseph F., Toutain, Pierre‐Louis, Pelligand, Ludovic

“…For clinical isolates of bovine Mannheimia haemolytica and Pasteurella multocida, this study reports minimum inhibitory concentration (MIC) differences for…”
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Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014) by Musuamba, FT, Manolis, E, Holford, N, Cheung, SYA, Friberg, LE, Ogungbenro, K, Posch, M, Yates, JWT, Berry, S, Thomas, N, Corriol‐Rohou, S, Bornkamp, B, Bretz, F, Hooker, AC, Van der Graaf, PH, Standing, JF, Hay, J, Cole, S, Gigante, V, Karlsson, K, Dumortier, T, Benda, N, Serone, F, Das, S, Brochot, A, Ehmann, F, Hemmings, R, Rusten, I Skottheim

“…Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of…”
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A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load by Johnson, SM, Standing, JF, Klein, N, Irwin, AD, Shingadia, D, Lonsdale, DO, Gilmour, KC, Flynn, J, Manns, C, Clapson, M, Bamford, A

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Pharmacokinetic-pharmacodynamic modeling of the hypotensive effect of remifentanil in infants undergoing cranioplasty by STANDING, JOSEPH F., HAMMER, GREGORY B., SAM, WAI JOHNN, DROVER, DAVID R.

“…Summary Objectives:  Although remifentanil has been used to induce hypotension during surgery in infants, no pharmacokinetic–pharmacodynamic (PKPD) model…”
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The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial by Neubert, Antje, Baarslag, Manuel Alberto, Dijk, Monique van, Rosmalen, Joost van, Standing, Joseph F, Sheng, Yucheng, Rascher, Wolfgang, Roberts, Deborah, Winslade, Jackie, Rawcliffe, Louise, Hanning, Sara M, Metsvaht, Tuuli, Giannuzzi, Viviana, Larsson, Peter, Pokorná, Pavla, Simonetti, Alessandra, Tibboel, Dick

“…IntroductionSedation is an essential part of paediatric critical care. Midazolam, often in combination with opioids, is the current gold standard drug…”
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Diclofenac for acute pain in children by Standing, Joseph F, Savage, Imogen, Pritchard, Deborah, Waddington, Marina

“…Diclofenac is commonly used for acute pain in children, but is not licensed for this indication in all age groups. 1) Assess the efficacy of diclofenac for…”
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New generalized poisson mixture model for bimodal count data with drug effect: An application to rodent brief‐access taste aversion experiments by Sheng, Y, Soto, J, Orlu Gul, M, Cortina‐Borja, M, Tuleu, C, Standing, JF

“…Pharmacodynamic (PD) count data can exhibit bimodality and nonequidispersion complicating the inclusion of drug effect. The purpose of this study was to…”
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Long-Term Bosentan Treatment in Children With Pulmonary Arterial Hypertension by Standing, Joseph F.

“…Bosentan may well be a useful agent in the treatment of pulmonary arterial hypertension in children; surely it is now time that a pediatric liquid formulation…”
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Population pharmacokinetics of oral diclofenac for acute pain in children by Standing, Joseph F., Howard, Richard F., Johnson, Atholl, Savage, Imogen, Wong, Ian C. K.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Diclofenac is an effective oral analgesic for acute postoperative pain. In adults 25 mg is half as effective as 50…”
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Prospective observational study of adverse drug reactions to diclofenac in children by Standing, Joseph F., Ooi, Kuan, Keady, Simon, Howard, Richard F., Savage, Imogen, Wong, Ian C. K.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Diclofenac is frequently used off‐label in children for acute pain, but little information is available on…”
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Chlorproguanil-dapsone for malaria by Standing, Joseph F, Wong, Ian CK

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