Search Results - "Standeven, Andrew M."

Inhibitors of TGFβR1/ALK4/JNK3/Flt1 Kinases in Cynomolgus Macaques Lead to the Rapid Induction of Renal Epithelial Tumors by Carreira, Vinicius, Standeven, Andrew M, Ma, Jing Ying, Hardisty, Jerry, Cohen, Samuel M, Kerns, Williams D, Snook, Sandra

“…Abstract Two young cynomolgus macaques (Macaca fascicularis) given a small molecule kinase inhibitor…”
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Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents by STANDEVEN, Andrew M, THACHER, Scott M, YUAN, Yang-Dar, ESCOBAR, Maria, VULIGONDA, Vidyasagar, BEARD, Richard L, CHANDRARATNA, Roshantha A. S

“…Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not…”
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Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis? by Standeven, Andrew M, Wetterhahn, Karen E

“…The purpose of this article is to critically review the evidence that reactive oxygen species are involved in the carcinogenic mechanism of Cr(VI). Since it is…”
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Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents 2 2Abbreviations: RARs, retinoic acid receptors; and RXRs, retinoid X receptors by Standeven, Andrew M., Thacher, Scott M., Yuan, Yang-Dar, Escobar, Maria, Vuligonda, Vidyasagar, Beard, Richard L., Chandraratna, Roshantha A.S.

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Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity by Beard, Richard L., Klein, Elliott S., Standeven, Andrew M., Escobar, Maria, Chandraratna, Roshantha A.S.

“…Retinoids are natural and synthetic analogues of the hormone retinoic acid. Systemic retinoid agonist therapy is usually associated with toxic side effects,…”
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Specific Antagonist of Retinoid Toxicity in Mice by Standeven, Andrew M., Johnson, Alan T., Escobar, Maria, Chandraratna, Roshantha A.S.

“…AGN 193109 was recently identified as a potent retinoic acid receptor (RAR) antagonistin vitro.The purpose of the present study was to determine if AGN 193109…”
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Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation by Thacher, S M, Standeven, A M, Athanikar, J, Kopper, S, Castilleja, O, Escobar, M, Beard, R L, Chandraratna, R A

“…Retinoid induction of epidermal hyperplasia was investigated in hairless mice with synthetic ligands for the retinoic acid (RAR) and retinoid X (RXR) nuclear…”
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Mitogenic effect of retinoid X receptor agonists in rat liver by Standeven, Andrew M., Escobar, Maria, Beard, Richard L., Yuan, Yang-Dar, Chandraratna, Roshantha A.S.

“…(E)-2-[2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-l-yl]-4-thiophenecar-boxylic acid (AGN 191701) and other retinoid X receptor…”
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Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice by STANDEVEN, A. M, WOLF, D. C, GOLDSWORTHY, T. L

“…We tested whether a concentration of unleaded gasoline (UG) vapor that was selectively hepatocarcinogenic in female mice in a chronic bioassay is…”
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Differential binding of chromium(VI) and chromium(III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA by Hneihen, A S, Standeven, A M, Wetterhahn, K E

“…The binding of CrCl3.6H2O, Cr(NO3)3.9H2O, [Cr(L-His)2] (NO3)3.H2O, [Cr(L-Cys)(L-His)].3.5H2O, [Cr(L-His)(D-Pen)].H2O, Na[Cr(L-Cys)2].2H2O, K2[Cr(GS)2].3H2O,…”
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Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver by Standeven, A M, Goldsworthy, T L

“…An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG) vapor acts as a liver tumor promoter in female mice under exposure…”
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Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, and mediates chromium-DNA binding in vitro by Standeven, A M, Wetterhahn, K E

“…Chromium(VI) reductase activity was measured in ultrafiltrates of rat lung after various pretreatments in vitro at 37 degrees C and pH 7.0. Pretreatment of…”
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Synthesis and biological activity of high-affinity retinoic acid receptor antagonists by JOHNSON, A. T, WANG, L, STANDEVEN, A. M, ESCOBAR, M, CHANDRARATNA, R. A. S

“…This article reports the synthesis and biological activity of new high affinity retinioic acid receptor (RAR) antagonists. The effect of introducing…”
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Ascorbate is the principal reductant of chromium (VI) in rat liver and kidney ultrafiltrates by Standeven, A M, Wetterhahn, K E

“…Chromium (VI) reductase activity was measured in ultrafiltrates of rat liver and kidney after various pretreatments in vitro at 37 degrees C and pH 7.0…”
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Lack of involvement of retinoic acid receptor α in retinoid-induced skin irritation in hairless mice by Standeven, Andrew M., Teng, Min, Chandraratna, Roshantha A.S.

“…It has been proposed that RARγ, the major retinoic acid receptor (RAR) subtype in skin, mediates retinoid-induced skin irritation. However, RARα is also found…”
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Promotion of Hepatic Preneoplastic Lesions in Male B6 C3 F1Mice by Unleaded Gasoline by Standeven, Andrew M., Wolf, Douglas C., Goldsworthy, Thomas L.

“…In previous studies, unleaded gasoline (UG) vapor was found to be a liver tumor promoter and hepatocarcinogen in female mice, but UG was not a hepatocarcinogen…”
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Promotion of Hepatic Preneoplastic Lesions in Male B6C3F 1 Mice by Unleaded Gasoline by Standeven, Andrew M., Wolf, Douglas C., Goldsworthy, Thomas L.

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A new class of potent rar antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids by Vuligonda, Vidyasagar, Standeven, Andrew M., Escobar, Maria, Chandraratna, Roshantha A.S.

“…The synthesis and biological activity of a novel series of tricyclic retinoic acid receptor antagonists are described. These compounds bind with high affinity…”
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A new class of RAR subtype selective retinoids: correlation of pharmacological effects with receptor activity by Vuligonda, V, Lin, Y, Thacher, S M, Standeven, A M, Kochar, D M, Chandraratna, R A

“…The synthesis and biological activity of a series of structurally related retinoids with different RAR subtype selectivities are described. These retinoids…”
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Cell Proliferation and regulation of negative growth factors in mouse liver foci by Moser, Glenda J., Wolf, Douglas C., Harden, Rebekah, Standeven, Andrew M., Mills, Jeremy, Jirtle, Randy L., Goldsworthy, Thomas L.

“…Foci of altered hepatocytes are preneoplastic lesions capable of progressing to hepatocellular carcinomas. To Characterize the growth of preneoplastic hepatic…”
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