Search Results - "Standaert, David"

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease by Hirsch, Etienne C., Standaert, David G.

“…Parkinson's disease is a progressive and debilitating disorder that has so far eluded attempts to develop disease‐modifying treatment. Both epidemiological and…”
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GLP-1, Parkinson’s Disease, and Neuroprotection by Standaert, David G.

“…Parkinson’s disease is a common and debilitating disorder. The best-known features are resting tremor, rigidity, and slowness, but recently a fuller picture of…”
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Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms by Wallen, Zachary D., Demirkan, Ayse, Twa, Guy, Cohen, Gwendolyn, Dean, Marissa N., Standaert, David G., Sampson, Timothy R., Payami, Haydeh

“…Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale study, at high…”
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microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease by Thome, Aaron D, Harms, Ashley S, Volpicelli-Daley, Laura A, Standaert, David G

“…Increasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by loss of…”
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Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection? by Calabresi, Paolo, Standaert, David G.

“…Dystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen…”
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CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease by Williams, Gregory P, Schonhoff, Aubrey M, Jurkuvenaite, Asta, Gallups, Nicole J, Standaert, David G, Harms, Ashley S

“…Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been implicated in the activation of the innate and adaptive immune system. This…”
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Update on the pathology of dystonia by Standaert, David G

“…Abstract Dystonia is a clinical syndrome with sustained muscle contraction, twisting, and abnormal postures. A number of different genetic forms have been…”
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Bridging the gaps: More inclusive research needed to fully understand Parkinson's disease by Gilbert, Rebecca M., Standaert, David G.

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α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease by Lindestam Arlehamn, Cecilia S., Dhanwani, Rekha, Pham, John, Kuan, Rebecca, Frazier, April, Rezende Dutra, Juliana, Phillips, Elizabeth, Mallal, Simon, Roederer, Mario, Marder, Karen S., Amara, Amy W., Standaert, David G., Goldman, Jennifer G., Litvan, Irene, Peters, Bjoern, Sulzer, David, Sette, Alessandro

“…A diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal…”
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Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease by Standaert, David G, Childers, Gabrielle M

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The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia by Cao, Shuwen, Standaert, David G, Harms, Ashley S

“…The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopamine-producing (DA) neurons in the substantia nigra (SN), has an important role…”
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Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease by Thome, Aaron D, Standaert, David G, Harms, Ashley S

“…Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and…”
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Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease by Fraser, Kyle B., Rawlins, Ashlee B., Clark, Rachel G., Alcalay, Roy N., Standaert, David G., Liu, Nianjun, West, Andrew B.

“…ABSTRACT Background Mutations in Leucine‐rich repeat kinase 2 (LRRK2) enhance levels of the autophosphorylated LRRK2 protein and are the most common known…”
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Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study by Olanow, C Warren, Prof, Kieburtz, Karl, MD, Odin, Per, MD, Espay, Alberto J, MD, Standaert, David G, MD, Fernandez, Hubert H, MD, Vanagunas, Arvydas, MD, Othman, Ahmed A, PhD, Widnell, Katherine L, MD, Robieson, Weining Z, PhD, Pritchett, Yili, PhD, Chatamra, Krai, PhD, Benesh, Janet, BSMT, Lenz, Robert A, MD, Antonini, Angelo, MD

“…Summary Background Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment is associated with the development of potentially…”
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Levodopa infusion therapies for Parkinson disease by Dean, Marissa N, Standaert, David G

“…to review recent progress in the development and use of continuous levodopa therapies in Parkinson disease (PD). Levodopa/Carbidopa intestinal gel (LCIG) is a…”
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LRRK2 inhibition attenuates microglial inflammatory responses by Moehle, Mark S, Webber, Philip J, Tse, Tonia, Sukar, Nour, Standaert, David G, DeSilva, Tara M, Cowell, Rita M, West, Andrew B

“…Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies…”
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The pathophysiological basis of dystonias by Breakefield, Xandra O, Blood, Anne J, Li, Yuqing, Hallett, Mark, Hanson, Phyllis I, Standaert, David G

“…Key Points Dystonia is a common and disabling movement disorder in humans. It encompasses a variety of different symptoms including torticollis, limb and trunk…”
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Striatal Synaptic Dysfunction in Dystonia and Levodopa-Induced Dyskinesia by Scarduzio, Mariangela, Hess, Ellen J., Standaert, David G., Eskow Jaunarajs, Karen L.

“…This review provides an overview of the synaptic dysfunctions of neuronal circuits and underlying neurochemical alterations observed in the hyperkinetic…”
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What would Dr. James Parkinson think today? Mutations in beta‐glucocerebrosidase and risk of Parkinson's disease by Standaert, David G.

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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease by Harms, Ashley S., Thome, Aaron D., Yan, Zhaoqi, Schonhoff, Aubrey M., Williams, Gregory P., Li, Xinru, Liu, Yudong, Qin, Hongwei, Benveniste, Etty N., Standaert, David G.

“…Accumulation of alpha-synuclein (α-syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate…”
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