Search Results - "Stanczak, Paulina"

A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment by Pilanc, Paulina, Wojnicki, Kamil, Roura, Adria-Jaume, Cyranowski, Salwador, Ellert-Miklaszewska, Aleksandra, Ochocka, Natalia, Gielniewski, Bartłomiej, Grzybowski, Marcin M, Błaszczyk, Roman, Stańczak, Paulina S, Dobrzański, Paweł, Kaminska, Bozena

“…Glioblastomas (GBM) are the common and aggressive primary brain tumors that are incurable by conventional therapies. Immunotherapy with immune checkpoint…”
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Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors by Blaszczyk, Roman, Brzezinska, Joanna, Dymek, Barbara, Stanczak, Paulina S, Mazurkiewicz, Marcin, Olczak, Jacek, Nowicka, Julita, Dzwonek, Karolina, Zagozdzon, Agnieszka, Golab, Jakub, Golebiowski, Adam

“…We designed and synthesized a series of arginase inhibitors as derivatives of the well-known 2-(S)-amino-6-boronohexanoic acid (ABH) with basic and neutral…”
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Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma by Sosnowska, Anna, Chlebowska-Tuz, Justyna, Matryba, Pawel, Pilch, Zofia, Greig, Alan, Wolny, Artur, Grzywa, Tomasz M., Rydzynska, Zuzanna, Sokolowska, Olga, Rygiel, Tomasz P., Grzybowski, Marcin, Stanczak, Paulina, Blaszczyk, Roman, Nowis, Dominika, Golab, Jakub

“…Immunotherapy has demonstrated significant activity in a broad range of cancer types, but still the majority of patients receiving it do not maintain durable…”
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Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3) by Yamani, Abdellah, Zdżalik-Bielecka, Daria, Lipner, Joanna, Stańczak, Aleksandra, Piórkowska, Natalia, Stańczak, Paulina Seweryna, Olejkowska, Patrycja, Hucz-Kalitowska, Joanna, Magdycz, Marta, Dzwonek, Karolina, Dubiel, Krzysztof, Lamparska-Przybysz, Monika, Popiel, Delfina, Pieczykolan, Jerzy, Wieczorek, Maciej

“…The FGFR family is characterized by four receptors (FGFR 1–4), binding to 18 ligands called fibroblast growth factors (FGFs). Aberrant activation of FGFs and…”
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Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer by Popiel, Delfina, Stańczak, Aleksandra, Skupińska, Monika, Mikołajczyk, Agata, Stańczak, Paulina, Mituła, Filip, Hucz-Kalitowska, Joanna, Jastrzębska, Kinga, Smuga, Damian, Dominowski, Jakub, Delis, Monika, Mulewski, Krzysztof, Pietruś, Wojciech, Zdżalik-Bielecka, Daria, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Yamani, Abdellah, Olejkowska, Patrycja, Piórkowska, Natalia, Dubiel, Krzysztof, Wieczorek, Maciej, Pieczykolan, Jerzy

“…Fibroblast Growth Factor Receptors (FGFRs) are a family of receptor tyrosine kinases expressed on a plethora of cell membranes. They play crucial roles in both…”
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Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives by Stypik, Mariola, Zagozda, Marcin, Michałek, Stanisław, Dymek, Barbara, Zdżalik-Bielecka, Daria, Dziachan, Maciej, Orłowska, Nina, Gunerka, Paweł, Turowski, Paweł, Hucz-Kalitowska, Joanna, Stańczak, Aleksandra, Stańczak, Paulina, Mulewski, Krzysztof, Smuga, Damian, Stefaniak, Filip, Gurba-Bryśkiewicz, Lidia, Leniak, Arkadiusz, Ochal, Zbigniew, Mach, Mateusz, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Dubiel, Krzysztof, Wieczorek, Maciej

“…Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation,…”
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Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy by Borek, Bartlomiej, Nowicka, Julita, Gzik, Anna, Dziegielewski, Marek, Jedrzejczak, Karol, Brzezinska, Joanna, Grzybowski, Marcin, Stanczak, Paulina, Pomper, Paulina, Zagozdzon, Agnieszka, Rejczak, Tomasz, Matyszewski, Krzysztof, Golebiowski, Adam, Olczak, Jacek, Lisiecki, Kamil, Tyszkiewicz, Magdalena, Kania, Magdalena, Piasecka, Sylwia, Cabaj, Anna, Dera, Paulina, Mulewski, Krzysztof, Chrzanowski, Jacek, Kusmirek, Damian, Sobolewska, Elzbieta, Magdycz, Marta, Mucha, Lukasz, Masnyk, Marek, Golab, Jakub, Nowotny, Marcin, Nowak, Elzbieta, Napiorkowska-Gromadzka, Agnieszka, Pikul, Stanislaw, Jazwiec, Radoslaw, Dzwonek, Karolina, Dobrzanski, Pawel, Meyring, Michael, Skowronek, Krzysztof, Iwanowski, Piotr, Zaslona, Zbigniew, Blaszczyk, Roman

“…Pharmacologic inhibition of the controlling immunity pathway enzymes arginases 1 and 2 (ARG1 and ARG2) is a promising strategy for cancer immunotherapy. Here,…”
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Abstract B003: Development of OAT-1746, a novel arginase 1 and 2 inhibitor for cancer immunotherapy by Stanczak, Paulina Seweryna, Grzybowski, Marcin Mikolaj, Wolska, Paulina, Zdziarska, Anna Maria, Mazurkiewicz, Marcin, Pilanc, Paulina, Gieryng, Anna, Kaminska, Bozena, Gzik, Anna, Dziegielewski, Marek, Jedrzejczak, Karol, Borek, Bartlomiej, Blaszczyk, Roman, Golebiowski, Adam, Dobrzanski, Pawel, Dzwonek, Karolina

“…Abstract Depletion of arginine represents an important mechanism of immunosuppression, and high plasma and tumor arginase (ARG) activity has been demonstrated…”
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OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer by Grzybowski, Marcin Mikołaj, Stańczak, Paulina Seweryna, Pomper, Paulina, Błaszczyk, Roman, Borek, Bartłomiej, Gzik, Anna, Nowicka, Julita, Jędrzejczak, Karol, Brzezińska, Joanna, Rejczak, Tomasz, Güner-Chalimoniuk, Nazan Cemre, Kikulska, Agnieszka, Mlącki, Michał, Pęczkowicz-Szyszka, Jolanta, Olczak, Jacek, Gołębiowski, Adam, Dzwonek, Karolina, Dobrzański, Paweł, Zasłona, Zbigniew

“…Background: Arginases play essential roles in metabolic pathways, determining the fitness of both immune and tumour cells. Along with the previously validated…”
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Design, Synthesis, and Development of pyrazolo[1,5-Ia/I]pyrimidine Derivatives as a Novel Series of Selective PI3KIδ/I Inhibitors: Part I—Indole Derivatives by Stypik, Mariola, Zagozda, Marcin, Michałek, Stanisław, Dymek, Barbara, Zdżalik-Bielecka, Daria, Dziachan, Maciej, Orłowska, Nina, Gunerka, Paweł, Turowski, Paweł, Hucz-Kalitowska, Joanna, Stańczak, Aleksandra, Stańczak, Paulina, Mulewski, Krzysztof, Smuga, Damian, Stefaniak, Filip, Gurba-Bryśkiewicz, Lidia, Leniak, Arkadiusz, Ochal, Zbigniew, Mach, Mateusz, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Dubiel, Krzysztof, Wieczorek, Maciej

“…Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation,…”
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