Search Results - "Stančíková, Jitka"
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Tviblindi algorithm identifies branching developmental trajectories of human B-cell development and describes abnormalities in RAG-1 and WAS patients
Published in European journal of immunology (05-09-2024)“…Detailed knowledge of human B-cell development is crucial for the proper interpretation of inborn errors of immunity and malignant diseases. It is of interest…”
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Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Published in Cancer cell (14-12-2015)“…The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in…”
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The role of individual caspases in cell death induction by taxanes in breast cancer cells
Published in Cancer cell international (04-02-2015)“…In previous study we showed that caspase-2 plays the role of an apical caspase in cell death induction by taxanes in breast cancer cells. This study deals with…”
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Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice
Published in International journal of molecular sciences (29-03-2019)“…Commensal microbiota contribute to gut homeostasis by inducing transcription of mucosal genes. Analysis of the impact of various microbiota on intestinal…”
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Auer rod-positive acute leukemia with predominantly lymphoid immunophenotype: Report on 11 cases and review of literature
Published in Pediatric blood & cancer (16-10-2024)“…Auer rods (AuRs) are prominent intracellular structures found almost exclusively in myeloid cell malignancies, such as acute myeloid leukemia (AML), chronic…”
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International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia
Published in Blood (19-07-2018)“…Despite attempts to improve the definitions of ambiguous lineage leukemia (ALAL) during the last 2 decades, general therapy recommendations are missing…”
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Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice
Published in Molecular cancer therapeutics (01-04-2014)“…The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the…”
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Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells
Published in Gastroenterology (New York, N.Y. 1943) (01-02-2013)“…Background & Aims The Wnt signaling pathway is required for maintenance of the intestinal epithelia; blocking this pathway reduces the proliferative capacity…”
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NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling
Published in Cellular signalling (01-02-2015)“…The activity of the Wnt pathway undergoes complex regulation to ensure proper functioning of this principal signaling mechanism during development of adult…”
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HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis
Published in Molecular cancer research (01-07-2015)“…Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The…”
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Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells
Published in Science immunology (12-01-2024)“…Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with…”
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