Search Results - "Stamper, Christopher T"

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets by Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.

“…Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used…”
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Broadly neutralizing antibodies target a haemagglutinin anchor epitope by Guthmiller, Jenna J., Han, Julianna, Utset, Henry A., Li, Lei, Lan, Linda Yu-Ling, Henry, Carole, Stamper, Christopher T., McMahon, Meagan, O’Dell, George, Fernández-Quintero, Monica L., Freyn, Alec W., Amanat, Fatima, Stovicek, Olivia, Gentles, Lauren, Richey, Sara T., de la Peña, Alba Torrents, Rosado, Victoria, Dugan, Haley L., Zheng, Nai-Ying, Tepora, Micah E., Bitar, Dalia J., Changrob, Siriruk, Strohmeier, Shirin, Huang, Min, García-Sastre, Adolfo, Liedl, Klaus R., Bloom, Jesse D., Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Coughlan, Lynda, Ward, Andrew B., Wilson, Patrick C.

“…Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against…”
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Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses by Guthmiller, Jenna J., Lan, Linda Yu-Ling, Fernández-Quintero, Monica L., Han, Julianna, Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Stovicek, Olivia, Li, Lei, Tepora, Micah, Henry, Carole, Neu, Karlynn E., Dugan, Haley L., Borowska, Marta T., Chen, Yao-Qing, Liu, Sean T.H., Stamper, Christopher T., Zheng, Nai-Ying, Huang, Min, Palm, Anna-Karin E., García-Sastre, Adolfo, Nachbagauer, Raffael, Palese, Peter, Coughlan, Lynda, Krammer, Florian, Ward, Andrew B., Liedl, Klaus R., Wilson, Patrick C.

“…Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon…”
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike by Guthmiller, Jenna J, Stovicek, Olivia, Wang, Jiaolong, Changrob, Siriruk, Li, Lei, Halfmann, Peter, Zheng, Nai-Ying, Utset, Henry, Stamper, Christopher T, Dugan, Haley L, Miller, William D, Huang, Min, Dai, Ya-Nan, Nelson, Christopher A, Hall, Paige D, Jansen, Maud, Shanmugarajah, Kumaran, Donington, Jessica S, Krammer, Florian, Fremont, Daved H, Joachimiak, Andrzej, Kawaoka, Yoshihiro, Tesic, Vera, Madariaga, Maria Lucia, Wilson, Patrick C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted…”
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Germline-encoded specificities and the predictability of the B cell response by Vieira, Marcos C, Palm, Anna-Karin E, Stamper, Christopher T, Tepora, Micah E, Nguyen, Khoa D, Pham, Tho D, Boyd, Scott D, Wilson, Patrick C, Cobey, Sarah

“…Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation…”
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Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike by Changrob, Siriruk, Fu, Yanbin, Guthmiller, Jenna J, Halfmann, Peter J, Li, Lei, Stamper, Christopher T, Dugan, Haley L, Accola, Molly, Rehrauer, William, Zheng, Nai-Ying, Huang, Min, Wang, Jiaolong, Erickson, Steven A, Utset, Henry A, Graves, Hortencia M, Amanat, Fatima, Sather, D Noah, Krammer, Florian, Kawaoka, Yoshihiro, Wilson, Patrick C

“…Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have arisen that exhibit increased viral transmissibility and partial evasion of…”
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Bcl6 is a subset-defining transcription factor of lymphoid tissue inducer-like ILC3 by Tachó-Piñot, Roser, Stamper, Christopher T., King, James I., Matei-Rascu, Veronika, Richardson, Erin, Li, Zhi, Roberts, Luke B., Bassett, John W., Melo-Gonzalez, Felipe, Fiancette, Rémi, Lin, I-Hsuan, Dent, Alexander, Harada, Yohsuke, Finlay, Conor, Mjösberg, Jenny, Withers, David R., Hepworth, Matthew R.

“…Innate lymphoid cells (ILCs) are tissue-resident effector cells with roles in tissue homeostasis, protective immunity, and inflammatory disease. Group 3 ILCs…”
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Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies by Kim, Youngchang, Maltseva, Natalia, Tesar, Christine, Jedrzejczak, Robert, Endres, Michael, Ma, Heng, Dugan, Haley L., Stamper, Christopher T., Chang, Changsoo, Li, Lei, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Ramanathan, Arvind, Wilson, Patrick, Michalska, Karolina, Joachimiak, Andrzej

“…Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting…”
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Improved integration of single-cell transcriptome and surface protein expression by LinQ-View by Li, Lei, Dugan, Haley L., Stamper, Christopher T., Lan, Linda Yu-Ling, Asby, Nicholas W., Knight, Matthew, Stovicek, Olivia, Zheng, Nai-Ying, Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Changrob, Siriruk, Utset, Henry A., Henry, Carole, Nelson, Christopher, Jedrzejczak, Robert P., Fremont, Daved H., Joachimiak, Andrzej, Krammer, Florian, Huang, Jun, Khan, Aly A., Wilson, Patrick C.

“…Multimodal advances in single-cell sequencing have enabled the simultaneous quantification of cell surface protein expression alongside unbiased…”
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Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies by Chen, Yao-Qing, Wohlbold, Teddy John, Zheng, Nai-Ying, Huang, Min, Huang, Yunping, Neu, Karlynn E., Lee, Jiwon, Wan, Hongquan, Rojas, Karla Thatcher, Kirkpatrick, Ericka, Henry, Carole, Palm, Anna-Karin E., Stamper, Christopher T., Lan, Linda Yu-Ling, Topham, David J., Treanor, John, Wrammert, Jens, Ahmed, Rafi, Eichelberger, Maryna C., Georgiou, George, Krammer, Florian, Wilson, Patrick C.

“…Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we…”
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Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial by Bernstein, David I, Guptill, Jeffrey, Naficy, Abdollah, Nachbagauer, Raffael, Berlanda-Scorza, Francesco, Feser, Jodi, Wilson, Patrick C, Solórzano, Alicia, Van der Wielen, Marie, Walter, Emmanuel B, Albrecht, Randy A, Buschle, Kristen N, Chen, Yao-qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Freeman, Debra, Gao, Min, Gast, Christopher, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Lan, Linda Yu-Ling, McNeal, Monica, Palm, Anna-Karin E, Shaw, Dustin G, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Wahid, Rahnuma, Wenzel, Heather, Wohlbold, Teddy John, Innis, Bruce L, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian

“…Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the…”
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Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans by Dugan, Haley L, Guthmiller, Jenna J, Arevalo, Philip, Huang, Min, Chen, Yao-Qing, Neu, Karlynn E, Henry, Carole, Zheng, Nai-Ying, Lan, Linda Yu-Ling, Tepora, Micah E, Stovicek, Olivia, Bitar, Dalia, Palm, Anna-Karin E, Stamper, Christopher T, Changrob, Siriruk, Utset, Henry A, Coughlan, Lynda, Krammer, Florian, Cobey, Sarah, Wilson, Patrick C

“…Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a result, preexisting influenza-specific memory B cells can dominate…”
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What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection? by Stamper, Christopher T, Wilson, Patrick C

“…Vaccinations are one of the greatest success stories of modern medicine, saving millions of lives since their widespread adoption. However, several diseases…”
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First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes by Guthmiller, Jenna J, Han, Julianna, Li, Lei, Freyn, Alec W, Liu, Sean T H, Stovicek, Olivia, Stamper, Christopher T, Dugan, Haley L, Tepora, Micah E, Utset, Henry A, Bitar, Dalia J, Hamel, Natalie J, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Krammer, Florian, Nachbagauer, Raffael, Palese, Peter, Ward, Andrew B, Wilson, Patrick C

“…Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009…”
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Single‐cell RNA sequencing of cells from fresh or frozen tissue reveals a signature of freezing marked by heightened stress and activation by Stamper, Christopher T., Marchalot, Anne, Tibbitt, Christopher A., Weigel, Whitney, Jangard, Mattias, Theorell, Jakob, Mjösberg, Jenny

“…Thawing of viably frozen human tissue T cells, ILCs, and NK cells and subsequent single‐cell RNA sequencing reveals that recovery of cellular subclusters is…”
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Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF by Kvedaraite, Egle, Lourda, Magda, Mouratidou, Natalia, Düking, Tim, Padhi, Avinash, Moll, Kirsten, Czarnewski, Paulo, Sinha, Indranil, Xagoraris, Ioanna, Kokkinou, Efthymia, Damdimopoulos, Anastasios, Weigel, Whitney, Hartwig, Olga, Santos, Telma E., Soini, Tea, Van Acker, Aline, Rahkonen, Nelly, Flodström Tullberg, Malin, Ringqvist, Emma, Buggert, Marcus, Jorns, Carl, Lindforss, Ulrik, Nordenvall, Caroline, Stamper, Christopher T., Unnersjö-Jess, David, Akber, Mira, Nadisauskaite, Ruta, Jansson, Jessica, Vandamme, Niels, Sorini, Chiara, Grundeken, Marijke Elise, Rolandsdotter, Helena, Rassidakis, George, Villablanca, Eduardo J., Ideström, Maja, Eulitz, Stefan, Arnell, Henrik, Mjösberg, Jenny, Henter, Jan-Inge, Svensson, Mattias

“…Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we…”
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Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity by Briquez, Priscilla S, Rouhani, Sherin J, Yu, Jovian, Pyzer, Athalia R, Trujillo, Jonathan, Dugan, Haley L, Stamper, Christopher T, Changrob, Siriruk, Sperling, Anne I, Wilson, Patrick C, Gajewski, Thomas F, Hubbell, Jeffrey A, Swartz, Melody A

“…Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can experience life-threatening respiratory distress, blood pressure…”
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Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens by Li, Lei, Changrob, Siriruk, Fu, Yanbin, Stovicek, Olivia, Guthmiller, Jenna J, McGrath, Joshua J C, Dugan, Haley L, Stamper, Christopher T, Zheng, Nai-Ying, Huang, Min, Wilson, Patrick C

“…Abstract Artificial mutagenesis and protein engineering have laid the foundation for antigenic characterization and universal vaccine design for influenza…”
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