Search Results - "Stammers, D."

Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD–YeaZ–YjeE complex by Nichols, C. E., Lamb, H.K., Thompson, P., Omari, K. El, Lockyer, M., Charles, I., Hawkins, A. R., Stammers, D. K.

“…YgjD from COG0533 is amongst a small group of highly conserved proteins present in all three domains of life. Various roles and biochemical functions…”
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Structure of HIV-2 Reverse Transcriptase at 2.35-Å Resolution and the Mechanism of Resistance to Non-Nucleoside Inhibitors by Ren, J., Bird, L. E., Chamberlain, P. P., Stewart-Jones, G. B., Stuart, D. I., Stammers, D. K.

“…The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and there is evidence for its spread to Europe and Asia. HIV-2 reverse…”
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Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors by Ren, J, Nichols, C, Bird, L, Chamberlain, P, Weaver, K, Short, S, Stuart, D I, Stammers, D K

“…Mutations at either Tyr181 or Tyr188 within HIV-1 reverse transcriptase (RT) give high level resistance to many first generation non-nucleoside inhibitors…”
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A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance by LARDER, B. A, BLOOR, S, STUART, D. I, PAUWELS, R, KEMP, S. D, HERTOGS, K, DESMET, R. L, MILLER, V, STURMER, M, STASZEWSKI, S, REN, J, STAMMERS, D. K

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Crystal Structures of HIV-1 Reverse Transcriptases Mutated at Codons 100, 106 and 108 and Mechanisms of Resistance to Non-nucleoside Inhibitors by Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Stammers, D.K

“…Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain…”
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The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases by Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R.

“…NmrA is a negative transcriptional regulator involved in the post‐translational modulation of the GATA‐type transcription factor AreA, forming part of a system…”
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Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215 by Chamberlain, P P, Ren, J, Nichols, C E, Douglas, L, Lennerstrand, J, Larder, B A, Stuart, D I, Stammers, D K

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Design of MKC-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants by Hopkins, Andrew L, Ren, Jingshan, Tanaka, Hiromichi, Baba, Masanori, Okamato, Mika, Stuart, David I, Stammers, David K

“…Two analogues of the nonnucleoside inhibitor of HIV-1 RT, MKC-442 (emivirine), containing different C6 substituents have been designed to be less susceptible…”
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Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors by Hopkins, Andrew L, Ren, Jingshan, Esnouf, Robert M, Willcox, Benjamin E, Jones, E. Yvonne, Ross, Carl, Miyasaka, Tadashi, Walker, Richard T, Tanaka, Hiromichi, Stammers, David K, Stuart, David I

“…Crystal structures of HIV-1 reverse transcriptase (RT) complexed with a range of chemically diverse non-nucleoside inhibitors (NNIs) have shown a single pocket…”
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Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog by Nichols, C.E., Johnson, C., Lockyer, M., Charles, I.G., Lamb, H.K., Hawkins, A.R., Stammers, D.K.

“…The Salmonella typhimurium “yeaZ” gene (StyeaZ) encodes an essential protein of unknown function (StYeaZ), which has previously been annotated as a putative…”
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Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase by Ren, Jingshan, Milton, John, Weaver, Kurt L., Short, Steven A., Stuart, David I., Stammers, David K.

“…Background: Efavirenz is a second-generation non-nucleoside inhibitor of HIV-1 reverse transcriptase (RT) that has recently been approved for use against HIV-1…”
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Correlation between Viral Resistance to Zidovudine and Resistance at the Reverse Transcriptase Level for a Panel of Human Immunodeficiency Virus Type 1 Mutants by Lennerstrand, J, Hertogs, K, Stammers, D K, Larder, B A

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High-resolution Structures Reveal Details of Domain Closure and “Half-of-sites-reactivity” in Escherichia coli Aspartate β-Semialdehyde Dehydrogenase by Nichols, C.E., Dhaliwal, B., Lockyer, M., Hawkins, A.R., Stammers, D.K.

“…Two high-resolution structures have been determined for Eschericia coli aspartate β-semialdehyde dehydrogenase ( ecASADH), an enzyme of the aspartate…”
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Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments by Nichols, C.E., Lockyer, M., Hawkins, A.R., Stammers, D.K.

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Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase by Harlos, Karl, Schofield, Christopher J, Zhang, Zhihong, Ren, Jingshan, Stammers, David K, Baldwin, Jack E

“…Clavaminate synthase (CAS), a remarkable Fe(II)/2-oxoglutarate oxygenase, catalyzes three separate oxidative reactions in the biosynthesis of clavulanic acid,…”
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Biochemical Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to Stavudine by LENNERSTRAND, Johan, STAMMERS, David K, LARDER, Brendan A

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Comparison of Ligand-induced Conformational Changes and Domain Closure Mechanisms, Between Prokaryotic and Eukaryotic Dehydroquinate Synthases by Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.

“…Dehydroquinate synthase (DHQS) is a potential target for the development of novel broad-spectrum antimicrobial drugs, active against both prokaryotes and lower…”
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Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form by El Omari, K., Dhaliwal, B., Ren, J., Abrescia, N. G. A., Lockyer, M., Powell, K. L., Hawkins, A. R., Stammers, D. K.

“…Respiratory syncytial virus (RSV) is a frequent cause of respiratory illness in infants, but there is currently no vaccine nor effective drug treatment against…”
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Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1 by Hopkins, Andrew L, Ren, Jingshan, Milton, John, Hazen, Richard J, Chan, Joseph H, Stuart, David I, Stammers, David K

“…We have used a structure-based approach to design a novel series of non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a wide range of…”
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A procedure for setting up high-throughput nanolitre crystallization experiments. II. Crystallization results by Brown, J., Walter, T. S., Carter, L., Abrescia, N. G. A., Aricescu, A. R., Batuwangala, T. D., Bird, L. E., Brown, N., Chamberlain, P. P., Davis, S. J., Dubinina, E., Endicott, J., Fennelly, J. A., Gilbert, R. J. C., Harkiolaki, M., Hon, W.-C., Kimberley, F., Love, C. A., Mancini, E. J., Manso-Sancho, R., Nichols, C. E., Robinson, R. A., Sutton, G. C., Schueller, N., Sleeman, M. C., Stewart-Jones, G. B., Vuong, M., Welburn, J., Zhang, Z., Stammers, D. K., Owens, R. J., Jones, E. Y., Harlos, K., Stuart, D. I.

“…An initial tranche of results from day‐to‐day use of a robotic system for setting up 100 nl‐scale vapour‐diffusion sitting‐drop protein crystallizations has…”
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