Search Results - "Stamateris, Evangelos"
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Restoration of Runx1 Expression in the Tie2 Cell Compartment Rescues Definitive Hematopoietic Stem Cells and Extends Life of Runx1 Knockout Animals Until Birth
Published in Stem cells (Dayton, Ohio) (01-07-2009)“…Mice deficient in the runt homology domain transcription factor Runx1/AML1 fail to generate functional clonogenic hematopoietic cells and die in utero by…”
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Cell Cycle Status of CD34+ Hemopoietic Stem Cells Determines Lentiviral Integration in Actively Transcribed and Development-related Genes
Published in Molecular therapy (01-04-2015)“…Gene therapy utilizing lentiviral-vectors (LVs) is postulated as a dynamic therapeutic alternative for monogenic diseases. However, retroviral gene transfer…”
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Characterization and comparative performance of lentiviral vector preparations concentrated by either one-step ultrafiltration or ultracentrifugation
Published in Virus research (01-07-2013)“…•A novel concentration protocol based on ultrafiltration without involving further purification steps is described.•This protocol results in high vector titers…”
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Cell Cycle Status of CD34 super(+) Hemopoietic Stem Cells Determines Lentiviral Integration in Actively Transcribed and Development-related Genes
Published in Molecular therapy (01-04-2015)“…Gene therapy utilizing lentiviral-vectors (LVs) is postulated as a dynamic therapeutic alternative for monogenic diseases. However, retroviral gene transfer…”
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The new self-inactivating lentiviral vector for thalassemia gene therapy combining two HPFH activating elements corrects human thalassemic hematopoietic stem cells
Published in Human gene therapy (01-01-2012)“…To address how low titer, variable expression, and gene silencing affect gene therapy vectors for hemoglobinopathies, in a previous study we successfully used…”
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The essential requirement for Runx1 in the development of the sternum
Published in Developmental biology (15-04-2010)“…Runx1 is highly expressed in chondroprogenitor and osteoprogenitor cells and in vitro experiments suggest that Runx1 is important in the early stages of…”
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