Search Results - "Stamatakos, Georgios S."

A Numerical Handling of the Boundary Conditions Imposed by the Skull on an Inhomogeneous Diffusion-Reaction Model of Glioblastoma Invasion Into the Brain: Clinical Validation Aspects by Stamatakos, Georgios S, Giatili, Stavroula G

“…A novel explicit triscale reaction-diffusion numerical model of glioblastoma multiforme tumor growth is presented. The model incorporates the handling of…”
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Exploiting clinical trial data drastically narrows the window of possible solutions to the problem of clinical adaptation of a multiscale cancer model by Stamatakos, Georgios S, Georgiadi, Eleni C, Graf, Norbert, Kolokotroni, Eleni A, Dionysiou, Dimitra D

“…The development of computational models for simulating tumor growth and response to treatment has gained significant momentum during the last few decades. At…”
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A Modular Repository-based Infrastructure for Simulation Model Storage and Execution Support in the Context of In Silico Oncology and In Silico Medicine by Christodoulou, Nikolaos A., Tousert, Nikolaos E., Georgiadi, Eleni Ch, Argyri, Katerina D., Misichroni, Fay D., Stamatakos, Georgios S.

“…The plethora of available disease prediction models and the ongoing process of their application into clinical practice – following their clinical validation –…”
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Clinical implications of in silico mathematical modeling for glioblastoma: a critical review by Protopapa, Maria, Zygogianni, Anna, Stamatakos, Georgios S., Antypas, Christos, Armpilia, Christina, Uzunoglu, Nikolaos K., Kouloulias, Vassilis

“…Glioblastoma remains a clinical challenge in spite of years of extensive research. Novel approaches are needed in order to integrate the existing knowledge…”
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Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway by Ouzounoglou, Eleftherios, Dionysiou, Dimitra, Stamatakos, Georgios S

“…As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein…”
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Studying the regression profiles of cervical tumours during radiotherapy treatment using a patient-specific multiscale model by Kyroudis, Christos A., Dionysiou, Dimitra D., Kolokotroni, Eleni A., Stamatakos, Georgios S.

“…Apart from offering insight into the biomechanisms involved in cancer, many recent mathematical modeling efforts aspire to the ultimate goal of clinical…”
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Introduction of Hypermatrix and Operator Notation into a Discrete Mathematics Simulation Model of Malignant Tumour Response to Therapeutic Schemes In Vivo. Some Operator Properties by Stamatakos, Georgios S., Dionysiou, Dimitra D.

“…Georgios S. Stamatakos and Dimitra D. DionysiouIn Silico Oncology Group, Laboratory of Microwaves and Fibre Optics, Institute of Communication and Computer…”
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A study on the predictability of acute lymphoblastic leukaemia response to treatment using a hybrid oncosimulator by Ouzounoglou, Eleftherios, Kolokotroni, Eleni, Stanulla, Martin, Stamatakos, Georgios S.

“…Efficient use of Virtual Physiological Human (VPH)-type models for personalized treatment response prediction purposes requires a precise model…”
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A detailed numerical treatment of the boundary conditions imposed by the skull on a diffusion–reaction model of glioma tumor growth. Clinical validation aspects by Giatili, Stavroula G., Stamatakos, Georgios S.

“…The study of the diffusive behavior of glioma tumor growth is an active field of biomedical research with considerable therapeutic implications. An important…”
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Applying a 4D Multiscale In Vivo Tumor Growth Model to the Exploration of Radiotherapy Scheduling: The Effects of Weekend Treatment Gaps and P53 Gene Status on the Response of Fast Growing Solid Tumors by Dionysiou, Dimitra D., Stamatakos, Georgios S.

“…The present paper aims at demonstrating clinically oriented applications of the multiscale four dimensional in vivo tumor growth simulation model previously…”
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Numerical simulation of vascular tumour growth under antiangiogenic treatment: addressing the paradigm of single-agent bevacizumab therapy with the use of experimental data by Argyri, Katerina D, Dionysiou, Dimitra D, Misichroni, Fay D, Stamatakos, Georgios S

“…Antiangiogenic agents have been recently added to the oncological armamentarium with bevacizumab probably being the most popular representative in current…”
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Coupling biomechanics to a cellular level model: An approach to patient-specific image driven multi-scale and multi-physics tumor simulation by May, Christian P., Kolokotroni, Eleni, Stamatakos, Georgios S., Büchler, Philippe

“…Modeling of tumor growth has been performed according to various approaches addressing different biocomplexity levels and spatiotemporal scales. Mathematical…”
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Towards in silico oncology: Adapting a four dimensional nephroblastoma treatment model to a clinical trial case based on multi-method sensitivity analysis by Georgiadi, Eleni Ch, Dionysiou, Dimitra D, Graf, Norbert, Stamatakos, Georgios S

“…Abstract In the past decades a great progress in cancer research has been made although medical treatment is still widely based on empirically established…”
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A four-dimensional simulation model of tumour response to radiotherapy in vivo: parametric validation considering radiosensitivity, genetic profile and fractionation by Dionysiou, Dimitra D., Stamatakos, Georgios S., Uzunoglu, Nikolaos K., Nikita, Konstantina S., Marioli, Antigoni

“…The aim of this paper is to present the current state of a four-dimensional simulation model of solid tumour growth and response to radiotherapy developed by…”
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A spatiotemporal, patient individualized simulation model of solid tumor response to chemotherapy in vivo: the paradigm of glioblastoma multiforme treated by temozolomide by Stamatakos, G.S., Antipas, V.P., Uzunoglu, N.K.

“…A novel four-dimensional, patient-specific Monte Carlo simulation model of solid tumor response to chemotherapeutic treatment in vivo is presented. The special…”
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Simulating chemotherapeutic schemes in the individualized treatment context: The paradigm of glioblastoma multiforme treated by temozolomide in vivo by Stamatakos, Georgios S., Antipas, Vassilis P., Uzunoglu, Nikolaos K.

“…A novel patient individualized, spatiotemporal Monte Carlo simulation model of tumor response to chemotherapeutic schemes in vivo is presented. Treatment of…”
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A computer simulation of in vivo tumour growth and response to radiotherapy: New algorithms and parametric results by Dionysiou, Dimitra D., Stamatakos, Georgios S., Uzunoglu, Nikolaos K., Nikita, Konstantina S.

“…The aim of this paper is to present the newest algorithms and simulation results of a computer model of in vivo tumour growth and response to radiotherapy. The…”
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Spotlight on Cancer Informatics by Stamatakos, Georgios S.

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A spatio-temporal simulation model of the response of solid tumours to radiotherapy in vivo: parametric validation concerning oxygen enhancement ratio and cell cycle duration by Antipas, Vassilis P, Stamatakos, Georgios S, Uzunoglu, Nikolaos K, Dionysiou, Dimitra D, Dale, Roger G

“…Advanced bio-simulation methods are expected to substantially improve radiotherapy treatment planning. To this end a novel spatio-temporal patient-specific…”
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Simulating growth dynamics and radiation response of avascular tumour spheroids—model validation in the case of an EMT6/Ro multicellular spheroid by Zacharaki, Evangelia I., Stamatakos, Georgios S., Nikita, Konstantina S., Uzunoglu, Nikolaos K.

“…The goal of this paper is to provide both the basic scientist and the clinician with an advanced computational tool for performing in silico experiments aiming…”
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