Search Results - "Stam, R W"

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale by Stumpel, D J P M, Schotte, D, Lange-Turenhout, E A M, Schneider, P, Seslija, L, de Menezes, R X, Marquez, V E, Pieters, R, den Boer, M L, Stam, R W

“…MLL- rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year) is the most aggressive type of childhood leukemia. To develop more suitable treatment…”
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Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia by Stumpel, D J P M, Schneider, P, Seslija, L, Osaki, H, Williams, O, Pieters, R, Stam, R W

“…MLL -rearranged infant acute lymphoblastic leukemia (ALL) is an aggressive type of leukemia characterized by a unique gene-expression profile. We uncovered…”
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Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia by Spijkers-Hagelstein, J A P, Mimoso Pinhanços, S, Schneider, P, Pieters, R, Stam, R W

“…MLL -rearranged infant acute lymphoblastic leukemia (ALL) (<1 year of age) are frequently resistant to glucocorticoids, like prednisone and dexamethasone. As…”
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Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia by Spijkers-Hagelstein, J A P, Schneider, P, Hulleman, E, de Boer, J, Williams, O, Pieters, R, Stam, R W

“…MLL -rearranged acute lymphoblastic leukemia (ALL) in infants is characterized by a poor clinical outcome and resistance to glucocorticoids (for example,…”
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Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL by Spijkers-Hagelstein, J A P, Pinhanços, S S, Schneider, P, Pieters, R, Stam, R W

“…Successful treatment results for MLL -rearranged Acute Lymphoblastic Leukemia (ALL) in infants remain difficult to achieve. Significantly contributing to…”
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Immunophenotypic analysis and quantification of B-1 and B-2 B cells during human fetal hematopoietic development by Bueno, C, van Roon, E H J, Muñoz-López, A, Sanjuan-Pla, A, Juan, M, Navarro, A, Stam, R W, Menendez, P

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Correction: NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL by Prieto, C., López-Millán, B., Roca-Ho, H., Stam, R. W., Romero-Moya, D., Rodríguez-Baena, F. J., Sanjuan-Pla, A., Ayllón, V., Ramírez, M., Bardini, M., De Lorenzo, P., Valsecchi, M. G., Stanulla, M., Iglesias, M., Ballerini, P., Carcaboso, Á. M., Mora, J., Locatelli, F., Bertaina, A., Padilla, L., Rodríguez-Manzaneque, Juan Carlos, Bueno, C., Menéndez, P.

“…The original version of this Article contained an error in the spelling of the author Juan Carlos Rodriguez-Manzaneque, which was incorrectly given as J Carlos…”
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Differential mRNA expression of Ara-C–metabolizing enzymes explains Ara-C sensitivity in MLL gene–rearranged infant acute lymphoblastic leukemia by Stam, Ronald W., den Boer, Monique L., Meijerink, Jules P.P., Ebus, Marli E.G., Peters, Godefridus J., Noordhuis, Paul, Janka-Schaub, Gritta E., Armstrong, Scott A., Korsmeyer, Stanley J., Pieters, Rob

“…Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangements, a poor outcome, and…”
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Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia by STAM, R. W, DEN BOER, M. L, PASSIER, M. M. C. J, JANKA-SCHAUB, G. E, SALLAN, S. E, ARMSTRONG, S. A, PIETERS, R

“…MLL rearranged acute lymphoblastic leukemia (MLL) is an aggressive type of acute lymphoblastic leukemia (ALL), diagnosed predominantly in infants (<1 years of…”
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The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis by Garrido Castro, P, van Roon, E H J, Pinhanços, S S, Trentin, L, Schneider, P, Kerstjens, M, te Kronnie, G, Heidenreich, O, Pieters, R, Stam, R W

“…MLL -rearranged acute lymphoblastic leukaemia (ALL) represents an aggressive malignancy in infants (<1 year of age), associated with poor outcome. Current…”
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Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein by STAM, R. W, VAN DEN HEUVEL-EIBRINK, M. M, DEN BOER, M. L, EBUS, M. E. G, JANKA-SCHAUB, G. E, ALLEN, J. D, PIETERS, R

“…Infants with acute lymphoblastic leukemia (ALL) are more resistant to chemotherapeutic drugs than older children with ALL, except for Ara-C. Drug resistance…”
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NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL by Prieto, C, López-Millán, B, Roca-Ho, H, Stam, R W, Romero-Moya, D, Rodríguez-Baena, F J, Sanjuan-Pla, A, Ayllón, V, Ramírez, M, Bardini, M, De Lorenzo, P, Valsecchi, M G, Stanulla, M, Iglesias, M, Ballerini, P, Carcaboso, Á M, Mora, J, Locatelli, F, Bertaina, A, Padilla, L, Carlos Rodríguez-Manzaneque, Juan, Bueno, C, Menéndez, P

“…Mixed-lineage leukemia (MLL)-rearranged (MLLr) infant B-cell acute lymphoblastic leukemia (iMLLr-B-ALL) has a dismal prognosis and is associated with a…”
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Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants by Driessen, E. M. C., van Roon, E. H. J., Spijkers-Hagelstein, J. A. P., Schneider, P., de Lorenzo, P., Valsecchi, M. G., Pieters, R., Stam, R. W.

“…Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the…”
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The human equilibrative nucleoside transporter I mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia by HUBEEK, I, STAM, R. W, KUIK, D. J, PIETERS, R, KASPERS, G. J. L, PETERS, G. J, BROEKHUIZEN, R, MEIJERINK, J. P. P, VAN WERING, E. R, GIBSON, B. E. S, CREUTZIG, U, ZWAAN, C. M, CLOOS, J

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MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia by Stam, R W, Hubeek, I, den Boer, M L, Buijs-Gladdines, J G C A M, Creutzig, U, Kaspers, G J L, Pieters, R

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Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23) by Coenen, E A, Zwaan, C M, Stary, J, Baruchel, A, de Haas, V, Stam, R W, Reinhardt, D, Kaspers, G J L, Arentsen-Peters, S T C J M, Meyer, C, Marschalek, R, Nigro, L L, Dworzak, M, Pieters, R, van den Heuvel-Eibrink, M M

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Targeting FLT3 in primary MLL-gene–rearranged infant acute lymphoblastic leukemia by Stam, Ronald W., den Boer, Monique L., Schneider, Pauline, Nollau, Peter, Horstmann, Martin, Beverloo, H. Berna, van der Voort, Ella, Valsecchi, Maria G., de Lorenzo, Paola, Sallan, Stephen E., Armstrong, Scott A., Pieters, Rob

“…Acute lymphoblastic leukemia (ALL) in infants is characterized by rearrangements of the mixed lineage leukemia (MLL) gene, drug resistance, and a poor…”
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The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia by Hubeek, I, Stam, R W, Peters, G J, Broekhuizen, R, Meijerink, J P P, van Wering, E R, Gibson, B E S, Creutzig, U, Zwaan, C M, Cloos, J, Kuik, D J, Pieters, R, Kaspers, G J L

“…Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia (AML). Aberrant expression of enzymes involved in the…”
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Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia by de Vries, Andrica C.H, Stam, Ronald W, Kratz, Christian P, Zenker, Martin, Niemeyer, Charlotte M, van den Heuvel-Eibrink, Marry M, on behalf of European Working Group on childhood MDS (EWOG-MDS)

“…* Department of Pediatric Oncology/Hematology, Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands ° Department of…”
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In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties by le Viseur, Christoph, Hotfilder, Marc, Bomken, Simon, Wilson, Kerrie, Röttgers, Silja, Schrauder, André, Rosemann, Annegret, Irving, Julie, Stam, Ronald W., Shultz, Leonard D., Harbott, Jochen, Jürgens, Heribert, Schrappe, Martin, Pieters, Rob, Vormoor, Josef

“…We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone…”
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