Search Results - "Stalpers, Lukas JA"

Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis by Meyners, Thekla, Heisterkamp, Christine, Kueter, Jan-Dirk, Veninga, Theo, Stalpers, Lukas J A, Schild, Steven E, Rades, Dirk

“…This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively…”
Get full text

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme by Verhoeff, Joost J C, van Tellingen, Olaf, Claes, An, Stalpers, Lukas J A, van Linde, Myra E, Richel, Dirk J, Leenders, William P J, van Furth, Wouter R

“…The relevance of angiogenesis inhibition in the treatment of glioblastoma multiforme (GBM) should be considered in the unique context of malignant brain…”
Get full text

Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice by Verhoeff, Joost J C, Stalpers, Lukas J A, Coumou, Annet W, Koedooder, Kees, Lavini, Cristina, Van Noorden, Cornelis J F, Haveman, Jaap, Vandertop, William P, van Furth, Wouter R

“…High-dose radiotherapy is standard treatment for patients with brain cancer. However, in preclinical research external beam radiotherapy is limited to…”
Get full text

The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures by Narayan, Ravi S, Fedrigo, Carlos A, Brands, Eelke, Dik, Rogier, Stalpers, Lukas J A, Baumert, Brigitta G, Slotman, Ben J, Westerman, Bart A, Peters, Godefridus J, Sminia, Peter

“…Glioblastoma multiforme (GBM) is the most common, invasive and deadly primary type of malignant brain tumor. The Phosphatidylinositol-3-Kinase/AKT (PI3K/AKT)…”
Get full text

Impaired survival and long-term neurological problems in benign meningioma by van Alkemade, Hanna, de Leau, Michelle, Dieleman, Edith M T, Kardaun, Jan W P F, van Os, Rob, Vandertop, W Peter, van Furth, Wouter R, Stalpers, Lukas J A

“…To assess long-term functional outcome and survival among patients with meningioma World Health Organization (WHO) grade I. Retrospective analysis of 205…”
Get full text

Final Results of a Prospective Study Comparing the Local Control of Short-Course and Long-Course Radiotherapy for Metastatic Spinal Cord Compression by Rades, Dirk, M.D, Lange, Marisa, M.D, Veninga, Theo, M.D, Stalpers, Lukas J.A., M.D, Bajrovic, Amira, M.D, Adamietz, Irenaeus A., M.D, Rudat, Volker, M.D, Schild, Steven E., M.D

“…Purpose Many patients with metastatic spinal cord compression (MSCC) live long enough to develop a recurrence in the irradiated spinal area. This is the first…”
Get full text

Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis by Oei, Arlene L, van Leeuwen, Caspar M, ten Cate, Rosemarie, Rodermond, Hans M, Buist, Marrije R, Stalpers, Lukas J A, Crezee, Johannes, Kok, H Petra, Medema, Jan Paul, Franken, Nicolaas A P

“…Human papillomavirus (HPV) is associated with cervical cancer, the third most common cancer in women. The high-risk HPV types 16 and 18 are found in over 70%…”
Get full text

BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas by Olow, Aleksandra, Mueller, Sabine, Yang, Xiaodong, Hashizume, Rintaro, Meyerowitz, Justin, Weiss, William, Resnick, Adam C, Waanders, Angela J, Stalpers, Lukas J A, Berger, Mitchel S, Gupta, Nalin, James, C David, Petritsch, Claudia K, Haas-Kogan, Daphne A

“…Alteration of the BRAF/MEK/MAPK pathway is the hallmark of pediatric low-grade gliomas (PLGGs), and mTOR activation has been documented in the majority of…”
Get full text

Feasibility of Electric Property Tomography of pelvic tumors at 3T by Balidemaj, Edmond, van Lier, Astrid L. H. M. W., Crezee, Hans, Nederveen, Aart J., Stalpers, Lukas J. A., van den Berg, Cornelis A. T.

“…Purpose Investigation of the validity of the “transceive phase assumption” for Electric Property Tomography of pelvic tumors at 3T. The acquired electric…”
Get full text

Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation by Van Nifterik, Krista A., Van den Berg, Jaap, Slotman, Ben J., Lafleur, M. Vincent M., Sminia, Peter, Stalpers, Lukas J. A.

“…Temozolomide (TMZ) is given in addition to radiotherapy in glioma patients, but its interaction with the commonly prescribed antiepileptic drug valproic acid…”
Get full text

Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination by van Oorschot, Bregje, Uitterhoeve, Lon, Oomen, Ilja, Ten Cate, Rosemarie, Medema, Jan Paul, Vrieling, Harry, Stalpers, Lukas J A, Moerland, Perry D, Franken, Nicolaas A P

“…Severe late damage to normal tissue is a major limitation of cancer radiotherapy in prostate cancer patients. In a recent retrospective study, late radiation…”
Get full text

Clinical characteristics of subsequent histologically confirmed meningiomas in long-term childhood cancer survivors: A Dutch LATER study by Verbruggen, Lisanne C., Kok, Judith L., Teepen, Jop C., Janssens, Geert O., de Boer, Charlotte M., Stalpers, Lukas J.A., Vernooij, Meike W., van Dulmen-den Broeder, Eline, Loonen, Jacqueline J., van den Heuvel-Eibrink, Marry M., Tissing, Wim J.E., van der Heiden-van der Loo, Margriet, Versluys, Anne Birgitta, Neggers, Sebastian J.C.M.M., van Leeuwen, Flora E., Hoving, Eelco W., Wesseling, Pieter, Kremer, Leontine C.M., Ronckers, Cécile M., van der Pal, Helena J.H., Louwerens, Marloes, de Vries, Andrica, Jaspers, Monique, Hollema, Nynke, den Hartogh, Jaap, Schouten-van Meeteren, Netteke

“…Meningiomas are the most frequent brain tumours occurring after pediatric cranial radiotherapy (CrRT). Data on course of disease, to inform clinical management…”
Get full text

Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma by Dasgupta, Tina, Olow, Aleksandra K., Yang, Xiaodong, Hashizume, Rintaro, Nicolaides, Theodore P., Tom, Maxwell, Aoki, Yasuyuki, Berger, Mitchel S., Weiss, William A., Stalpers, Lukas J. A., Prados, Michael, David James, C., Mueller, Sabine, Haas-Kogan, Daphne A.

“…Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of…”
Get full text

Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma by Narayan, Ravi S, Gasol, Ana, Slangen, Paul L G, Cornelissen, Fleur M G, Lagerweij, Tonny, Veldman, Hou Y Y E, Dik, Rogier, van den Berg, Jaap, Slotman, Ben J, Würdinger, Tom, Haas-Kogan, Daphne A, Stalpers, Lukas J A, Baumert, Brigitta G, Westerman, Bart A, Theys, Jan, Sminia, Peter

“…Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K and MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not…”
Get full text

Results of radical surgery in women with stage IB2/IIA2 cervical cancer by Derks, Marloes, Biewenga, Petra, van der Velden, Jacobus, Kenter, Gemma G, Stalpers, Lukas J A, Buist, Marrije R

“…There is ongoing discussion about the primary treatment of women with bulky early-stage cervical cancer. Because of the high number of patients who need…”
Get more information

Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial by Homs, Marjolein YV, Steyerberg, Ewout W, Eijkenboom, Wilhelmina MH, Tilanus, Hugo W, Stalpers, Lukas JA, Bartelsman, Joep FWM, van Lanschot, Jan JB, Wijrdeman, Harm K, Mulder, Chris JJ, Reinders, Janny G, Boot, Henk, Aleman, Berthe MP, Kuipers, Ernst J, Siersema, Peter D

“…Both single-dose brachytherapy and self-expanding metal stent placement are commonly used for palliation of oesophageal obstruction due to inoperable cancer,…”
Get full text

Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients by van Nieuwenhuizen, David, Klein, Martin, Stalpers, Lukas J A, Leenstra, Sieger, Heimans, Jan J, Reijneveld, Jaap C

“…Potential treatment-related neurotoxicity and the indolent course of the disease mainly feed the controversy concerning the optimal timing of surgery and…”
Get full text

B1-based SAR reconstruction using contrast source inversion–electric properties tomography (CSI-EPT) by Balidemaj, Edmond, van den Berg, Cornelis A. T., van Lier, Astrid L. H. M. W., Nederveen, Aart J., Stalpers, Lukas J. A., Crezee, Hans, Remis, Rob F.

“…Specific absorption rate (SAR) assessment is essential for safety purposes during MR acquisition. Online SAR assessment is not trivial and requires, in…”
Get full text

Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining by Bergs, Judith W.J., Krawczyk, Przemek M., Borovski, Tijana, ten Cate, Rosemarie, Rodermond, Hans M., Stap, Jan, Medema, Jan Paul, Haveman, Jaap, Essers, Jeroen, van Bree, Chris, Stalpers, Lukas J.A., Kanaar, Roland, Aten, Jacob A., Franken, Nicolaas A.P.

“…► We examined hat mild hyperthermia inhibited homologous recombination repair. ► We examined translocation formation after hyperthermia. ► Inhibition of HR…”
Get full text

The indication area of a diagnostic test. Part I—discounting gain and loss in diagnostic certainty by Stalpers, Lukas J.A, Nelemans, Patty J, Geurts, Sandra M.E, Jansen, Erik, de Boer, Peter, Verbeek, André L.M

“…Abstract Objectives Test performance is conventionally expressed by gain in diagnostic certainty. We propose net diagnostic gain and indication area as more…”
Get full text