Search Results - "Staller, Peter"

The KDM5 family of histone demethylases as targets in oncology drug discovery by Rasmussen, Peter Birk, Staller, Peter

“…There is growing evidence for a causal role of the KDM5 family of histone demethylases in human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B…”
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The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF by Beyer, Sophie, Kristensen, Malene Maag, Jensen, Kim Steen, Johansen, Jens Vilstrup, Staller, Peter

“…Posttranslational histone modifications serve to store epigenetic information and control both nucleosome assembly and recruitment of non-histone proteins…”
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FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function by Jensen, Kim Steen, Binderup, Tina, Jensen, Klaus Thorleif, Therkelsen, Ib, Borup, Rehannah, Nilsson, Elise, Multhaupt, Hinke, Bouchard, Caroline, Quistorff, Bjørn, Kjær, Andreas, Landberg, Göran, Staller, Peter

“…Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia‐inducible factor 1 (HIF‐1). HIF‐1 mediates induction of…”
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HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases by Paroni, Gabriela, Bolis, Marco, Zanetti, Adriana, Ubezio, Paolo, Helin, Kristian, Staller, Peter, Gerlach, Lars Ole, Fratelli, Maddalena, Neve, Richard M., Terao, Mineko, Garattini, Enrico

“…Targeting of histone methylation has therapeutic potential in oncology. Here, we provide proof-of-principle that pharmacological inhibition of KDM5…”
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The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover by Coffey, Kelly, Rogerson, Lynsey, Ryan-Munden, Claudia, Alkharaif, Dhuha, Stockley, Jacqueline, Heer, Rakesh, Sahadevan, Kanagasabai, O'Neill, Daniel, Jones, Dominic, Darby, Steven, Staller, Peter, Mantilla, Alejandra, Gaughan, Luke, Robson, Craig N

“…The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by…”
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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL by Krek, Wilhelm, Staller, Peter, Sulitkova, Jitka, Lisztwan, Joanna, Moch, Holger, Oakeley, Edward J

“…Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For…”
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Abstract A29: Genome-wide CRISPR/Cas9 screens for the identification of novel YAP1/TAZ modulators by Naujoks, Jan, Potze, Lisette, Kuehnlenz, Julia, Kamburov, Atanas, Nevedomskaya, Ekaterina, Steffen, Andreas, Luther, Claudia, Anurin, Anna, Buttgereit, Anne, Prechtl, Stefan, Bader, Benjamin, Lesche, Ralf, Staller, Peter, Lange, Martin, Nicke, Barbara

“…Abstract Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ in…”
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Abstract 6089: Identification of novel YAP/TAZ pathway regulators in the triple-negative breast cancer cell line MDA-MB231 using single-cell CRISPR screening by Berlak, Mareike, Makowska, Zuzanna, Klironomos, Filippos, Kuehnlenz, Julia, Kamburov, Atanas, Steffen, Andreas, Lange, Martin, Nicke, Barbara, Lesche, Ralf, Staller, Peter, Kopitz, Charlotte, Naujoks, Jan

“…Abstract The Hippo signaling cascade is a major pathway that integrates a broad spectrum of mechanosensory signals at the plasma membrane and regulates…”
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Abstract 5161: The development of therapeutic inhibitors of the KDM5 histone demethylases by Hudlebusch, Heidi R., Heinemann, Bo, Nielsen, Jesper M., Kleine-Kohlbrecher, Daniela, Hauge, Camilla, Boesen, Thomas, Labelle, Marc, Gerlach, Lars-Ole, Staller, Peter, Birk, Peter

“…Abstract Histone methyl marks contribute to the regulation of chromatin architecture and of DNA-based processes such as replication, repair and gene…”
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Control of cell proliferation by Myc by Bouchard, Caroline, Staller, Peter, Eilers, Martin

“…Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the…”
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Mutual requirement of CDK4 and Myc in malignant transformation : Evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc by HAAS, K, STALLER, P, GEISEN, C, BARTEK, J, EILERS, M, MÖRÖY, T

“…We demonstrate in this paper that CDK4 which is a G1 phase specific cell cycle regulator and catalytic subunit of D-type cyclins has oncogenic activity similar…”
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An alternative pathway for gene regulation by Myc by Peukert, Karen, Staller, Peter, Schneider, Andreas, Carmichael, Gordon, Hänel, Frank, Eilers, Martin

“…The c‐Myc protein activates transcription as part of a heteromeric complex with Max. However, Myc‐transformed cells are characterized by loss of expression of…”
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FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function: FoxO3A inhibits Myc to control hypoxic metabolism by Jensen, Kim Steen, Binderup, Tina, Jensen, Klaus Thorleif, Therkelsen, Ib, Borup, Rehannah, Nilsson, Elise, Multhaupt, Hinke, Bouchard, Caroline, Quistorff, Bjørn, Kjaer, Andreas, Landberg, Göran, Staller, Peter

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The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIFS by Beyer, Sophie, Kristensen, Malene Maag, Jensen, Kim Steen, Johansen, Jens Vilstrup, Staller, Peter

“…Posttranslational histone modifications serve to store epigenetic information and control both nucleosome assembly and recruitment of non-histone proteins…”
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Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms by ELLIOTT, K, SAKAMURO, D, PRENDERGAST, G. C, BASU, A, WEI DU, WUNNER, W, STALLER, P, GAUBATZ, S, HONG ZHANG, PROCHOWNIK, E, EILERS, M

“…The tumor suppressor Bin1 was identified through its interaction with the N-terminal region of Myc which harbors its transcriptional activation domain. Here we…”
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TGF[beta] influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b by Seoane, Joan, Pouponnot, Celio, Staller, Peter, Schader, Manuela, Eilers, Martin, Massagué, Joan

“…Transforming growth factor-beta (TGFbeta) is a cytokine that arrests epithelial cell division by switching off the proto-oncogene c-myc and rapidly switching…”
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TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b by Seoane, Joan, Pouponnot, Celio, Staller, Peter, Schader, Manuela, Eilers, Martin, Massagué, Joan

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TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15 INK4b by Massagué, Joan, Seoane, Joan, Pouponnot, Celio, Staller, Peter, Schader, Manuela, Eilers, Martin

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Repression of p15 INK4b expression by Myc through association with Miz-1 by Eilers, Martin, Staller, Peter, Peukert, Karen, Kiermaier, Astrid, Seoane, Joan, Lukas, Jiri, Karsunky, Holger, Möröy, Tarik, Bartek, Jiri, Massagué, Joan, Hänel, Frank

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Repression of p15INK4b expression by Myc through association with Miz-1 by Staller, P, Peukert, K, Kiermaier, A, Seoane, J, Lukas, J, Karsunky, H, Möröy, T, Bartek, J, Massagué, J, Hänel, F, Eilers, M

“…Deregulated expression of c-myc can induce cell proliferation in established cell lines and in primary mouse embryonic fibroblasts (MEFs), through a…”
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