Search Results - "Staley, James R."

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations by Kamat, Mihir A, Blackshaw, James A, Young, Robin, Surendran, Praveen, Burgess, Stephen, Danesh, John, Butterworth, Adam S, Staley, James R

“…Abstract Summary PhenoScanner is a curated database of publicly available results from large-scale genetic association studies in humans. This online tool…”
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A robust and efficient method for Mendelian randomization with hundreds of genetic variants by Burgess, Stephen, Foley, Christopher N, Allara, Elias, Staley, James R, Howson, Joanna M. M.

“…Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to distinguish correlation from causation in observational data. The…”
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PhenoScanner: a database of human genotype-phenotype associations by Staley, James R, Blackshaw, James, Kamat, Mihir A, Ellis, Steve, Surendran, Praveen, Sun, Benjamin B, Paul, Dirk S, Freitag, Daniel, Burgess, Stephen, Danesh, John, Young, Robin, Butterworth, Adam S

“…PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate 'phenome scans',…”
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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits by Foley, Christopher N., Staley, James R., Breen, Philip G., Sun, Benjamin B., Kirk, Paul D. W., Burgess, Stephen, Howson, Joanna M. M.

“…Genome-wide association studies (GWAS) have identified thousands of genomic regions affecting complex diseases. The next challenge is to elucidate the causal…”
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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease by Astle, William J., Elding, Heather, Jiang, Tao, Allen, Dave, Ruklisa, Dace, Mann, Alice L., Mead, Daniel, Bouman, Heleen, Riveros-Mckay, Fernando, Kostadima, Myrto A., Lambourne, John J., Sivapalaratnam, Suthesh, Downes, Kate, Kundu, Kousik, Bomba, Lorenzo, Berentsen, Kim, Bradley, John R., Daugherty, Louise C., Delaneau, Olivier, Freson, Kathleen, Garner, Stephen F., Grassi, Luigi, Guerrero, Jose, Haimel, Matthias, Janssen-Megens, Eva M., Kaan, Anita, Kamat, Mihir, Kim, Bowon, Mandoli, Amit, Marchini, Jonathan, Martens, Joost H.A., Meacham, Stuart, Megy, Karyn, O’Connell, Jared, Petersen, Romina, Sharifi, Nilofar, Sheard, Simon M., Staley, James R., Tuna, Salih, van der Ent, Martijn, Walter, Klaudia, Wang, Shuang-Yin, Wheeler, Eleanor, Wilder, Steven P., Iotchkova, Valentina, Moore, Carmel, Sambrook, Jennifer, Stunnenberg, Hendrik G., Di Angelantonio, Emanuele, Kaptoge, Stephen, Kuijpers, Taco W., Carrillo-de-Santa-Pau, Enrique, Juan, David, Rico, Daniel, Valencia, Alfonso, Chen, Lu, Ge, Bing, Vasquez, Louella, Kwan, Tony, Garrido-Martín, Diego, Watt, Stephen, Yang, Ying, Guigo, Roderic, Beck, Stephan, Paul, Dirk S., Pastinen, Tomi, Bujold, David, Bourque, Guillaume, Frontini, Mattia, Danesh, John, Roberts, David J., Ouwehand, Willem H., Butterworth, Adam S., Soranzo, Nicole

“…Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a…”
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases by Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

“…The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the…”
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The EWAS Catalog: a database of epigenome-wide association studies by Battram, Thomas, Yousefi, Paul, Crawford, Gemma, Prince, Claire, Sheikhali Babaei, Mahsa, Sharp, Gemma, Hatcher, Charlie, Vega-Salas, María Jesús, Khodabakhsh, Sahar, Whitehurst, Oliver, Langdon, Ryan, Mahoney, Luke, Elliott, Hannah R, Mancano, Giulia, Lee, Matthew A, Watkins, Sarah H, Lay, Abigail C, Hemani, Gibran, Gaunt, Tom R, Relton, Caroline L, Staley, James R, Suderman, Matthew

“…Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG…”
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Coding and regulatory variants are associated with serum protein levels and disease by Emilsson, Valur, Gudmundsdottir, Valborg, Gudjonsson, Alexander, Jonmundsson, Thorarinn, Jonsson, Brynjolfur G., Karim, Mohd A., Ilkov, Marjan, Staley, James R., Gudmundsson, Elias F., Launer, Lenore J., Lindeman, Jan H., Morton, Nicholas M., Aspelund, Thor, Lamb, John R., Jennings, Lori L., Gudnason, Vilmundur

“…Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between…”
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DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample by Kandaswamy, Radhika, Hannon, Eilis, Arseneault, Louise, Mansell, Georgina, Sugden, Karen, Williams, Benjamin, Burrage, Joe, Staley, James R, Pishva, Ehsan, Dahir, Aisha, Roberts, Susanna, Danese, Andrea, Mill, Jonathan, Fisher, Helen L, Wong, Chloe C. Y.

“…Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to…”
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Semiparametric methods for estimation of a nonlinear exposure‐outcome relationship using instrumental variables with application to Mendelian randomization by Staley, James R., Burgess, Stephen

“…ABSTRACT Mendelian randomization, the use of genetic variants as instrumental variables (IV), can test for and estimate the causal effect of an exposure on an…”
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Associations of Blood Pressure in Pregnancy With Offspring Blood Pressure Trajectories During Childhood and Adolescence: Findings From a Prospective Study by Staley, James R., Bradley, John, Silverwood, Richard J., Howe, Laura D., Tilling, Kate, Lawlor, Debbie A., Macdonald‐Wallis, Corrie

“…Background Hypertensive disorders of pregnancy are related to higher offspring blood pressure (BP), but it is not known whether this association strengthens or…”
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MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data by Broadbent, Jim R., Foley, Christopher N., Grant, Andrew J., Mason, Amy M., Staley, James R., Burgess, Stephen

“…The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on…”
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Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al by Staley, James R, Giannakopoulou, Olga, Holdsworth, Gill, Armstrong, Martin

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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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The EWAS Catalog: a database of epigenome-wide association studies by Battram, Thomas, Yousefi, Paul, Crawford, Gemma, Prince, Claire, Sheikhali Babaei, Mahsa, Sharp, Gemma, Hatcher, Charlie, Vega-Salas, María Jesús, Khodabakhsh, Sahar, Whitehurst, Oliver, Langdon, Ryan, Mahoney, Luke, Elliott, Hannah R., Mancano, Giulia, Lee, Matthew A., Watkins, Sarah H., Lay, Abigail C., Hemani, Gibran, Gaunt, Tom R., Relton, Caroline L., Staley, James R., Suderman, Matthew

“…Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG…”
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Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses by Sun, Yi-Qian, Burgess, Stephen, Staley, James R, Wood, Angela M, Bell, Steven, Kaptoge, Stephen K, Guo, Qi, Bolton, Thomas R, Mason, Amy M, Butterworth, Adam S, Di Angelantonio, Emanuele, Vie, Gunnhild Å, Bjørngaard, Johan H, Kinge, Jonas Minet, Chen, Yue, Mai, Xiao-Mei

“…AbstractObjectiveTo investigate the shape of the causal relation between body mass index (BMI) and mortality.DesignLinear and non-linear mendelian…”
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The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A 2-Sample Mendelian Randomization Study by Leppert, Beate, Riglin, Lucy, Wootton, Robyn E, Dardani, Christina, Thapar, Ajay, Staley, James R, Tilling, Kate, Davey Smith, George, Thapar, Anita, Stergiakouli, Evie

“…Attention-deficit/hyperactivity disorder (ADHD) is associated with a broad range of physical health problems. Using different research designs to test whether…”
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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension by Surendran, Praveen, Drenos, Fotios, Witkowska, Kate, Tragante, Vinicius, Freitag, Daniel F, Tinker, Andrew, Harakalova, Magdalena, Rasheed, Asif, Bonnycastle, Lori L, Jackson, Anne U, Narisu, Narisu, Swift, Amy J, Ohlsson, Therese, Matchan, Angela, Stirrups, Kathleen E, Bork-Jensen, Jette, Gjesing, Anette P, Havulinna, Aki S, Zhang, He, Donnelly, Louise A, Neville, Matt J, Robertson, Neil R, Yiorkas, Andrianos M, Herzig, Karl-Heinz, Zhang, Weihua, Trabetti, Elisabetta, Evangelou, Evangelos, Moayyeri, Alireza, Nelson, Christopher P, de Craen, Anton J M, Trompet, Stella, Scott, Robert A, Marioni, Riccardo, Farmaki, Aliki-Eleni, Hallmans, Göran, Hassinen, Maija, Burgess, Stephen, Uria-Nickelsen, Maria, Reilly, Dermot F, Vogt, Thomas F, Traylor, Matthew, Justice, Anne E, Marouli, Eirini, Uusitupa, Matti, Polasek, Ozren, Rudan, Igor, Rolandsson, Olov, Dedoussis, George, Starr, John M, Brown, Morris J, Sattar, Naveed, Packard, Chris J, Mägi, Reedik, Metspalu, Andres, de Boer, Rudolf A, van der Meer, Peter, van der Harst, Pim, Lind, Lars, de Bakker, Paul I W, Korpi-Hyövälti, Eeva, Oksa, Heikki, Linneberg, Allan, Thuesen, Betina, Doney, Alex S F, Morris, Andrew D, Palmer, Colin N A, Holmen, Oddgeir Lingaas, Willer, Cristen J, Palotie, Aarno, Ripatti, Samuli, Majumder, Abdulla al Shafi, Chowdhury, Rajiv, Poulter, Neil, Sever, Peter, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrières, Jean, Müller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, Deloukas, Panos, Elliott, Paul, Melander, Olle, Kuusisto, Johanna, Laakso, Markku, Padmanabhan, Sandosh, Porteous, David J, Mohlke, Karen L, Pedersen, Oluf, Stringham, Heather M, Newton-Cheh, Christopher, Caulfield, Mark J, Morris, Andrew P, Tomaszewski, Maciej, Saleheen, Danish, Asselbergs, Folkert W, Wain, Louise V, Butterworth, Adam S, Howson, Joanna M M

“…Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their…”
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A robust mean and variance test with application to high-dimensional phenotypes by Staley, James R., Windmeijer, Frank, Suderman, Matthew, Lyon, Matthew S., Davey Smith, George, Tilling, Kate

“…Most studies of continuous health-related outcomes examine differences in mean levels (location) of the outcome by exposure. However, identifying effects on…”
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Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans by Holdsworth, Gill, Staley, James R, Hall, Peter, Koeverden, Ian, Vangjeli, Ciara, Okoye, Remi, Boyce, Rogely W, Turk, James R, Armstrong, Martin, Wolfreys, Alison, Pasterkamp, Gerard

“…ABSTRACT Inhibition of sclerostin increases bone formation and decreases bone resorption, leading to increased bone mass, bone mineral density, and bone…”
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