Search Results - "Staley, J K"

Local Impermeant Anions Establish the Neuronal Chloride Concentration by Glykys, J., Dzhala, V., Egawa, K., Balena, T, Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T., Staley, K. J.

“…Neuronal intracellular chloride concentration [Cl–]i is an important determinant of γ-aminobutyric acid type A (GABAA) receptor (GABAAR)–mediated inhibition…”
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Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water by Glykys, J., Duquette, E., Rahmati, N., Duquette, K., Staley, K.J.

“…Seizures and brain injury lead to water and Cl− accumulation in neurons. The increase in intraneuronal Cl− concentration ([Cl−]i) depolarizes the GABAA…”
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Interictal Spikes Precede Ictal Discharges in an Organotypic Hippocampal Slice Culture Model of Epileptogenesis by Dyhrfjeld-Johnsen, J, Berdichevsky, Y, Swiercz, W, Sabolek, H, Staley, K. J

“…In organotypic hippocampal slice cultures, principal neurons form aberrant excitatory connections with other principal cells in response to slicing induced…”
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Response to comments on "Local impermeant anions establish the neuronal chloride concentration" by Glykys, J, Dzhala, V, Egawa, K, Balena, T, Saponjian, Y, Kuchibhotla, K V, Bacskai, B J, Kahle, K T, Zeuthen, T, Staley, K J

“…We appreciate the interest in our paper and the opportunity to clarify theoretical and technical aspects describing the influence of Donnan equilibria on…”
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Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings by Staley, K J, Otis, T S, Mody, I

“…1. Whole-cell and sharp electrode recordings from adult rat dentate gyrus GCs were performed in the 400-microns-thick hippocampal slice preparation maintained…”
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Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors by STALEY, K. J, SOLDO, B. L, PROCTOR, W. R

“…Gamma-aminobutyric acid A (GABAA) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABAA receptors…”
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Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report by Jacobsen, Leslie K., Staley, Julie K., Zoghbi, Sami S., Seibyl, John P., Kosten, Thomas R., Innis, Robert B., Gelernter, Joel

“…OBJECTIVE: Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes. METHOD: The…”
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Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations by Lillis, Kyle P, Wang, Zemin, Mail, Michelle, Zhao, Grace Q, Berdichevsky, Yevgeny, Bacskai, Brian, Staley, Kevin J

“…In secondary epilepsy, a seizure-prone neural network evolves during the latent period between brain injury and the onset of spontaneous seizures. The nature…”
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High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims by Staley, J K, Hearn, W L, Ruttenber, A J, Wetli, C V, Mash, D C

“…Cocaine mediates its powerful reinforcement by binding to recognition sites on the dopamine (DA) transporter. The pharmacological identity of cocaine…”
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Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition by Smith, RL, Clayton, GH, Wilcox, CL, Escudero, KW, Staley, KJ

“…A voltage-sensitive inwardly rectifying chloride (Cl-) conductance (GCl(V) is present in hippocampal pyramidal but not dentate gyrus neurons and has a…”
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Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression by Staley, Julie K, Malison, Robert T, Innis, Robert B

“…For nearly three decades, evidence supporting a role for aberrant serotonergic function in the pathogenesis of depression has accumulated; however, only…”
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Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients by Jacobsen, Leslie K., Staley, Julie K., Malison, Robert T., Zoghbi, Sami S., Seibyl, John P., Kosten, Thomas R., Innis, Robert B.

“…OBJECTIVE: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for…”
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Characterization of Promoter Function and Cell-Type-Specific Expression from Viral Vectors in the Nervous System by Smith, R L, Traul, D L, Schaack, J, Clayton, G H, Staley, K J, Wilcox, C L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Immunochemical analysis of dopamine transporter protein in Parkinson's disease by Miller, G W, Staley, J K, Heilman, C J, Perez, J T, Mash, D C, Rye, D B, Levey, A I

“…The plasma membrane dopamine transporter (DAT) is considered to be a reliable marker of presynaptic dopaminergic terminal loss. Previous in vivo imaging and…”
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Vesicular Acetylcholine Transporter Density and Alzheimer’s Disease by Efange, S.M.N, Garland, E.M, Staley, J.K, Khare, A.B, Mash, D.C

“…We have evaluated the vesamicol analogue meta-[ 125I]iodobenzyltrozamicol {(+)-[ 125I]MIBT} as a probe to assess cholinergic terminal integrity in the human…”
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Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex by Mash, D.C., Staley, J.K., Pablo, J.P., Holohean, A.M., Hackman, J.C., Davidoff, R.A.

“…The putative anti-addiction alkaloid ibogaine and its principal metabolite 12-hydroxyibogamine appear to act at the (+)-5 methyl-10,11-dihydro-5 H-dibenzo[…”
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Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release by Otis, T S, Staley, K J, Mody, I

“…Miniature spontaneous inhibitory postsynaptic currents (sIPSCs) mediated by GABAA receptors were recorded using whole-cell patch clamp recordings in rat brain…”
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Transition from Interictal to Ictal Activity in Limbic Networks In Vitro by Dzhala, Volodymyr I, Staley, Kevin J

“…The transition from brief bursts of synchronous population activity characteristic of interictal epileptiform discharges (IEDs) to more prolonged epochs of…”
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Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization by Staley, J K, Basile, M, Flynn, D D, Mash, D C

“…The cocaine analogue RTI-55 was evaluated as a probe for in vitro labeling and localization of dopamine and serotonin transporters after death in the human…”
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Excitatory Actions of Endogenously Released GABA Contribute to Initiation of Ictal Epileptiform Activity in the Developing Hippocampus by Dzhala, Volodymyr I, Staley, Kevin J

“…In the developing rat hippocampus, ictal epileptiform activity can be elicited easily in vitro during the first three postnatal weeks. Changes in neuronal ion…”
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