Identification of receptors for neuromedin U and its role in feeding

Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It is widely distributed in the gut and central nervous system. Peripheral activities of NMU include stimulation of smooth muscle, increase of bl...

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Bibliographic Details
Published in:	Nature (London) Vol. 406; no. 6791; pp. 70 - 74
Main Authors:	Liu, Qingyun, Howard, Andrew D, Wang, Ruiping, Pong, Sheng-Shung, Mellin, Theodore N, Strack, Alison, Guan, Xiao-Ming, Zeng, Zhizhen, Williams, David L, Feighner, Scott D, Nunes, Christian N, Murphy, Beth, Stair, Judith N, Yu, Hong, Jiang, Qingping, Clements, Michelle K, Tan, Carina P, McKee, Karen K, Hreniuk, Donna L, McDonald, Terrence P, Lynch, Kevin R, Evans, Jilly F, Austin, Christopher P, Caskey, C. Thomas, Van der Ploeg, Lex H. T
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 06-07-2000 Nature Publishing Group
Subjects:	Amino Acid Sequence Animals Biological and medical sciences Blood pressure Brain - metabolism Cell Line Central nervous system Cloning, Molecular Fasting Feeding Behavior - physiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Genomics Humans Ion transport Ligands Membrane Proteins Mice Molecular Sequence Data Molecules Nervous system neuromedin U receptors Neuropeptides - metabolism Obesity - metabolism Peptides Proteins Radioligand Assay Rats Receptors, Cell Surface - analysis Receptors, Cell Surface - physiology Receptors, Neurotransmitter - analysis Receptors, Neurotransmitter - physiology RNA, Messenger - metabolism Sequence Alignment Space life sciences Tissue Distribution Vertebrates: anatomy and physiology, studies on body, several organs or systems Feeding behavior Rat Nucleotide sequence Rodentia Central nervous system Binding site Neuropeptide Neuromedin U Vertebrata Mammalia Peptidergic receptor Biological receptor Brain (vertebrata)
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Summary:	Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It is widely distributed in the gut and central nervous system. Peripheral activities of NMU include stimulation of smooth muscle, increase of blood pressure, alteration of ion transport in the gut, control of local blood flow and regulation of adrenocortical function. An NMU receptor has not been molecularly identified. Here we show that the previously described orphan G-protein-coupled receptor FM-3 (ref. 15) and a newly discovered one (FM-4) are cognate receptors for NMU. FM-3, designated NMU1R, is abundantly expressed in peripheral tissues whereas FM-4, designated NMU2R, is expressed in specific regions of the brain. NMU is expressed in the ventromedial hypothalamus in the rat brain, and its level is significantly reduced following fasting. Intracerebroventricular administration of NMU markedly suppresses food intake in rats. These findings provide a molecular basis for the biochemical activities of NMU and may indicate that NMU is involved in the central control of feeding.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-0836 1476-4687
DOI:	10.1038/35017610