Search Results - "Staines, M"

Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing by Augustin, Yolanda, Staines, Henry M., Krishna, Sanjeev

“…Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is…”
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Ensembl Genomes 2020—enabling non-vertebrate genomic research by Howe, Kevin L, Contreras-Moreira, Bruno, De Silva, Nishadi, Maslen, Gareth, Akanni, Wasiu, Allen, James, Alvarez-Jarreta, Jorge, Barba, Matthieu, Bolser, Dan M, Cambell, Lahcen, Carbajo, Manuel, Chakiachvili, Marc, Christensen, Mikkel, Cummins, Carla, Cuzick, Alayne, Davis, Paul, Fexova, Silvie, Gall, Astrid, George, Nancy, Gil, Laurent, Gupta, Parul, Hammond-Kosack, Kim E, Haskell, Erin, Hunt, Sarah E, Jaiswal, Pankaj, Janacek, Sophie H, Kersey, Paul J, Langridge, Nick, Maheswari, Uma, Maurel, Thomas, McDowall, Mark D, Moore, Ben, Muffato, Matthieu, Naamati, Guy, Naithani, Sushma, Olson, Andrew, Papatheodorou, Irene, Patricio, Mateus, Paulini, Michael, Pedro, Helder, Perry, Emily, Preece, Justin, Rosello, Marc, Russell, Matthew, Sitnik, Vasily, Staines, Daniel M, Stein, Joshua, Tello-Ruiz, Marcela K, Trevanion, Stephen J, Urban, Martin, Wei, Sharon, Ware, Doreen, Williams, Gary, Yates, Andrew D, Flicek, Paul

“…Abstract Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the…”
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PomBase: a comprehensive online resource for fission yeast by Wood, Valerie, Harris, Midori A., McDowall, Mark D., Rutherford, Kim, Vaughan, Brendan W., Staines, Daniel M., Aslett, Martin, Lock, Antonia, Bähler, Jürg, Kersey, Paul J., Oliver, Stephen G.

“…PomBase (www.pombase.org) is a new model organism database established to provide access to comprehensive, accurate, and up-to-date molecular data and…”
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Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial by Agnandji, Selidji T, Fernandes, José F, Bache, Emmanuel B, Obiang Mba, Régis M, Brosnahan, Jessica S, Kabwende, Lumeka, Pitzinger, Paul, Staarink, Pieter, Massinga-Loembe, Marguerite, Krähling, Verena, Biedenkopf, Nadine, Fehling, Sarah Katharina, Strecker, Thomas, Clark, David J, Staines, Henry M, Hooper, Jay W, Silvera, Peter, Moorthy, Vasee, Kieny, Marie-Paule, Adegnika, Akim A, Grobusch, Martin P, Becker, Stephan, Ramharter, Michael, Mordmüller, Benjamin, Lell, Bertrand, Krishna, Sanjeev, Kremsner, Peter G

“…The rVSVΔG-ZEBOV-GP vaccine prevented Ebola virus disease when used at 2 × 107 plaque-forming units (PFU) in a trial in Guinea. This study provides further…”
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A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium by Slavic, Ksenija, Krishna, Sanjeev, Lahree, Aparajita, Bouyer, Guillaume, Hanson, Kirsten, Vera, Iset, Pittman, Jon K., Staines, Henry M., Mota, Maria Manuel

“…© Copyright © 2016, The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party…”
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Self-sampling of capillary blood for SARS-CoV-2 serology by Brown, Lottie, Byrne, Rachel L., Fraser, Alice, Owen, Sophie I., Cubas-Atienzar, Ana I., Williams, Christopher T., Kay, Grant A., Cuevas, Luis E., Fitchett, Joseph R. A., Fletcher, Tom, Garrod, Gala, Kontogianni, Konstantina, Krishna, Sanjeev, Menzies, Stefanie, Planche, Tim, Sainter, Chris, Staines, Henry M., Turtle, Lance, Adams, Emily R.

“…Serological testing is emerging as a powerful tool to progress our understanding of COVID-19 exposure, transmission and immune response. Large-scale testing is…”
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Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis by Savage, Helen R, Santos, Victor S, Edwards, Thomas, Giorgi, Emanuele, Krishna, Sanjeev, Planche, Timothy D, Staines, Henry M, Fitchett, Joseph R A, Kirwan, Daniela E, Cubas Atienzar, Ana I, Clark, David J, Adams, Emily R, Cuevas, Luis E

“…Individuals infected with SARS-CoV-2 develop neutralising antibodies. We investigated the proportion of individuals with SARS-CoV-2 neutralising antibodies…”
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The QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay for rapid detection of COVID-19 at point-of-care: preliminary evaluation of a novel technology by Caffry, Jessica, Selby, Matthew, Barr, Katie, Morgan, George, McGurk, David, Scully, Philip, Park, Catherine, Caridis, Anna-Maria, Southworth, Emily, Morrison, Jack, Clark, David J., Davies, Benedict M. O., Eckersley, Nicholas M., Groppelli, Elisabetta, Kirwan, Daniela E., Monahan, Irene, Augustin, Yolanda, Toombs, Colin, Planche, Tim, Staines, Henry M., Krishna, Sanjeev

“…Accurate and rapid point-of-care (PoC) diagnostics are critical to the control of the COVID-19 pandemic. The current standard for accurate diagnosis of…”
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Determining the critical plant test potassium concentration for annual and Italian ryegrass on dairy pastures in south‐western Australia by McDonnell, R. P., Staines, M. vH, Bolland, M. D. A.

“…Potassium fertilization in intensive grassland systems is particularly important on sandy soils with limited K storage capacity. A 3‐year plot experiment was…”
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Uptake and metabolism of arginine impact Plasmodium development in the liver by Meireles, Patrícia, Mendes, António M., Aroeira, Rita I., Mounce, Bryan C., Vignuzzi, Marco, Staines, Henry M., Prudêncio, Miguel

“…Prior to infecting erythrocytes and causing malaria symptoms, Plasmodium parasites undergo an obligatory phase of invasion and extensive replication inside…”
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SARS-CoV-2 enzyme-linked immunosorbent assays as proxies for plaque reduction neutralisation tests by Kay, Grant A., Owen, Sophie I., Giorgi, Emanuele, Clark, David J., Williams, Christopher T., Menzies, Stefanie, Cuevas, Luis E., Davies, Benedict M. O., Eckersley, Nicholas M., Hughes, Grant L., Kirwan, Daniela E., Krishna, Sanjeev, Patterson, Edward I., Planche, Tim, Staines, Henry M., Adams, Emily R.

“…Severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread globally since its emergence in 2019. Most SARS-CoV-2 infections generate immune responses…”
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An efficient and novel technology for the extraction of parasite genomic DNA from whole blood or culture by Clark, David J, Moore, Catherine M, Flanagan, Marc, Bocxlaer, Katrien Van, Piperaki, Evangelia-Theophano, Yardley, Vanessa, Croft, Simon L, Tyson, John, Whitehouse, Sam P, O'Halloran, Jonathan, Krishna, Sanjeev, Staines, Henry M

“…The aim of this study was to assess pathogen DNA extraction with a new spin column-based method (DNA-XT). DNA from either whole-blood samples spiked with or …”
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Pumped up: reflections on PfATP6 as the target for artemisinins by Krishna, Sanjeev, Pulcini, Serena, Moore, Catherine M, Teo, Beatrix Huei-Yi, Staines, Henry M

“…Highlights • Artemisinins are our most important class of antimalarial drugs. • PfATP6, a SERCA pump, is a proposed target for artemisinins in parasites. •…”
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The BioMart community portal: an innovative alternative to large, centralized data repositories by Smedley, Damian, Haider, Syed, Durinck, Steffen, Pandini, Luca, Provero, Paolo, Allen, James, Arnaiz, Olivier, Awedh, Mohammad Hamza, Baldock, Richard, Barbiera, Giulia, Bardou, Philippe, Beck, Tim, Blake, Andrew, Bonierbale, Merideth, Brookes, Anthony J, Bucci, Gabriele, Buetti, Iwan, Burge, Sarah, Cabau, Cédric, Carlson, Joseph W, Chelala, Claude, Chrysostomou, Charalambos, Cittaro, Davide, Collin, Olivier, Cordova, Raul, Cutts, Rosalind J, Dassi, Erik, Di Genova, Alex, Djari, Anis, Esposito, Anthony, Estrella, Heather, Eyras, Eduardo, Fernandez-Banet, Julio, Forbes, Simon, Free, Robert C, Fujisawa, Takatomo, Gadaleta, Emanuela, Garcia-Manteiga, Jose M, Goodstein, David, Gray, Kristian, Guerra-Assunção, José Afonso, Haggarty, Bernard, Han, Dong-Jin, Han, Byung Woo, Harris, Todd, Harshbarger, Jayson, Hastings, Robert K, Hayes, Richard D, Hoede, Claire, Hu, Shen, Hu, Zhi-Liang, Hutchins, Lucie, Kan, Zhengyan, Kawaji, Hideya, Keliet, Aminah, Kerhornou, Arnaud, Kim, Sunghoon, Kinsella, Rhoda, Klopp, Christophe, Kong, Lei, Lawson, Daniel, Lazarevic, Dejan, Lee, Ji-Hyun, Letellier, Thomas, Li, Chuan-Yun, Lio, Pietro, Liu, Chu-Jun, Luo, Jie, Maass, Alejandro, Mariette, Jerome, Maurel, Thomas, Merella, Stefania, Mohamed, Azza Mostafa, Moreews, Francois, Nabihoudine, Ibounyamine, Ndegwa, Nelson, Noirot, Céline, Perez-Llamas, Cristian, Primig, Michael, Quattrone, Alessandro, Quesneville, Hadi, Rambaldi, Davide, Reecy, James, Riba, Michela, Rosanoff, Steven, Saddiq, Amna Ali, Salas, Elisa, Sallou, Olivier, Shepherd, Rebecca, Simon, Reinhard, Sperling, Linda, Spooner, William, Staines, Daniel M, Steinbach, Delphine, Stone, Kevin, Stupka, Elia, Teague, Jon W, Dayem Ullah, Abu Z, Wang, Jun, Ware, Doreen

“…The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed…”
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Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes by Pulcini, Serena, Staines, Henry M., Pittman, Jon K., Slavic, Ksenija, Doerig, Christian, Halbert, Jean, Tewari, Rita, Shah, Falgun, Avery, Mitchell A., Haynes, Richard K., Krishna, Sanjeev

“…Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of…”
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Performance of five pasture-based dairy systems with increasing levels of nitrogen fertiliser and associated stocking rates by Staines, M. V. H., Morris, R. J., Bolland, M. D. A., McDonnell, R. P.

“…A farm systems experiment comparing five pasture-based dairy systems was conducted in south-western Australia over 4 years on an annual ryegrass:subterranean…”
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Susceptibility of human Plasmodium knowlesi infections to anti-malarials by Fatih, Farrah A, Staines, Henry M, Siner, Angela, Ahmed, Mohammed Atique, Woon, Lu Chan, Pasini, Erica M, Kocken, Clemens Hm, Singh, Balbir, Cox-Singh, Janet, Krishna, Sanjeev

“…Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have…”
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Patient preference and acceptability of self-sampling for cervical screening in colposcopy clinic attenders: A cross-sectional semi-structured survey by Webb, Sophie, Mat Ali, Nafeesa, Sawyer, Amy, Clark, David J, Brown, Megan A, Augustin, Yolanda, Woo, Yin Ling, Khoo, Su Pei, Hargreaves, Sally, Staines, Henry M, Krishna, Sanjeev, Hayes, Kevin

“…Low vaginal self-sampling has been pioneered as an important development to improve uptake of cervical screening globally. Limited research is available in…”
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Ensembl Plants: Integrating Tools for Visualizing, Mining, and Analyzing Plant Genomics Data by Bolser, Dan, Staines, Daniel M, Pritchard, Emily, Kersey, Paul

“…Ensembl Plants ( http://plants.ensembl.org ) is an integrative resource presenting genome-scale information for a growing number of sequenced plant species…”
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The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development by Guttery, David S, Pittman, Jon K, Frénal, Karine, Poulin, Benoit, McFarlane, Leon R, Slavic, Ksenija, Wheatley, Sally P, Soldati-Favre, Dominique, Krishna, Sanjeev, Tewari, Rita, Staines, Henry M

“…Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and…”
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