Search Results - "Stainer, Alexander"

Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen by Bye, Alexander P, Unsworth, Amanda J, Vaiyapuri, Sakthivel, Stainer, Alexander R, Fry, Michael J, Gibbins, Jonathan M

“…OBJECTIVE—Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia,…”
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Pharmacological actions of nobiletin in the modulation of platelet function by Vaiyapuri, Sakthivel, Roweth, Harvey, Ali, Marfoua S, Unsworth, Amanda J, Stainer, Alexander R, Flora, Gagan D, Crescente, Marilena, Jones, Chris I, Moraes, Leonardo A, Gibbins, Jonathan M

“…Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic…”
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Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets by Sahli, Khaled A., Flora, Gagan D., Sasikumar, Parvathy, Maghrabi, Ali H., Holbrook, Lisa-Marie, AlOuda, Sarah K., Elgheznawy, Amro, Sage, Tanya, Stainer, Alexander R., Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vaiyapuri, Sakthivel, Bye, Alexander P., Unsworth, Amanda J., Jones, Chris I., McGuffin, Liam J., Gibbins, Jonathan M.

“…Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and…”
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Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis by Flora, Gagan D., Sahli, Khaled A., Sasikumar, Parvathy, Holbrook, Lisa-Marie, Stainer, Alexander R., AlOuda, Sarah K., Crescente, Marilena, Sage, Tanya, Unsworth, Amanda J., Gibbins, Jonathan M.

“…The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the…”
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Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling by Unsworth, Amanda J, Bye, Alexander P, Sage, Tanya, Gaspar, Renato S, Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J, Hutchinson, James L, Riley, Ryan, Jones, Sarah, Mundell, Stuart J, Cui, Weiguo, Falet, Hervé, Gibbins, Jonathan M

“…Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and…”
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1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis by Alatawi, Kahdr A, Ravishankar, Divyashree, Patra, Pabitra H, Bye, Alexander P, Stainer, Alexander R, Patel, Ketan, Widera, Darius, Vaiyapuri, Sakthivel

“…1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole…”
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EphB2 regulates contact-dependent and contact-independent signaling to control platelet function by Vaiyapuri, Sakthivel, Sage, Tanya, Rana, Rekha H., Schenk, Michael P., Ali, Marfoua S., Unsworth, Amanda J., Jones, Chris I., Stainer, Alexander R., Kriek, Neline, Moraes, Leonardo A., Gibbins, Jonathan M.

“…The Eph kinases, EphA4 and EphB1, and their ligand, ephrinB1, have been previously reported to be present in platelets where they contribute to thrombus…”
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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions by Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S, Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T, Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E

“…A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin…”
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The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects by Stainer, Alexander R, Sasikumar, Parvathy, Bye, Alexander P, Unsworth, Amanda J, Holbrook, Lisa M, Tindall, Marcus, Lovegrove, Julie A, Gibbins, Jonathan M

“…Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in…”
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The relationship between the metabolites of the dietary flavonoid quercetin, and haemostasis and thrombosis : an integrated systems approach by Stainer, Alexander

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Ibrutinib Inhibits Platelet Integrin α IIb β 3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen by Bye, Alexander P., Unsworth, Amanda J., Vaiyapuri, Sakthivel, Stainer, Alexander R., Fry, Michael J., Gibbins, Jonathan M.

“…Objective— Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia,…”
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Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability by Mitchell, Joanne L., Little, Gemma, Bye, Alexander P., Gaspar, Renato S., Unsworth, Amanda J., Kriek, Neline, Sage, Tanya, Stainer, Alexander, Sangowawa, Ibidayo, Morrow, Gael B., Bastos, Ricardo N., Shapiro, Susan, Desborough, Michael J.R., Curry, Nicola, Gibbins, Jonathan M., Whyte, Claire S., Mutch, Nicola J., Jones, Christopher I.

“…Factor XIII (FXIII) is an important proenzyme in the hemostatic system. The plasma-derived enzyme activated FXIII cross-links fibrin fibers within thrombi to…”
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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions: e1005011 by Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S, Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T, Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E

“…A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin…”
Get full text