Search Results - "Stahle, Mary C."

Integrin Priming Dynamics: Mechanisms of Integrin Antagonist-Promoted αIIbβ3:PAC-1 Molecular Recognition by Hantgan, Roy R, Stahle, Mary C

“…This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting αIIbβ3 integrin, while macromolecules with similar…”
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Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding by Hantgan, Roy R, Stahle, Mary C, Lord, Susan T

“…This study demonstrates that two orthogonal events regulate integrin αIIbβ3's interactions with fibrinogen, its primary physiological ligand: (1)…”
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Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure by Hantgan, Roy R, Stahle, Mary C, Jerome, W Gray, Nagaswami, Chandrasekaran, Weisel, John W

“…A biophysical approach tested the hypothesis that tirofiban, like eptifibatide, perturbs GpIIb/IIIa structure. Tirofiban bound tightly to platelet GpIIb/IIIa…”
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Entropy Drives Integrin αIIbβ3:Echistatin Binding—Evidence from Surface Plasmon Resonance Spectroscopy by Hantgan, Roy R, Stahle, Mary C, Horita, David A

“…This investigation examined the molecular mechanisms that enable the αIIbβ3 integrin to bind efficiently, tightly, and selectively to echistatin, an RGD…”
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Entropy drives integrin alphaIIbbeta3:echistatin binding--evidence from surface plasmon resonance spectroscopy by Hantgan, Roy R, Stahle, Mary C, Horita, David A

“…This investigation examined the molecular mechanisms that enable the alphaIIbbeta3 integrin to bind efficiently, tightly, and selectively to echistatin, an RGD…”
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Integrin αIIbβ3:ligand interactions are linked to binding‐site remodeling by Hantgan, Roy R., Stahle, Mary C., Connor, John H., Horita, David A., Rocco, Mattia, McLane, Mary A., Yakovlev, Sergiy, Medved, Leonid

“…This study tested the hypothesis that high‐affinity binding of macromolecular ligands to the αIIbβ3 integrin is tightly coupled to binding‐site remodeling, an…”
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The Disintegrin Echistatin Stabilizes Integrin αIIbβ3's Open Conformation and Promotes Its Oligomerization by Hantgan, Roy R., Stahle, Mary C., Connor, John H., Lyles, Douglas S., Horita, David A., Rocco, Mattia, Nagaswami, Chandrasekaran, Weisel, John W., McLane, Mary Ann

“…We have employed echistatin, a 5.4 kDa snake venom disintegrin, as a model protein to investigate the paradox that small ligand-mimetics can bind to the…”
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Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition by Hantgan, Roy R, Stahle, Mary C

“…This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting alphaIIbbeta3 integrin, while macromolecules with…”
Get full text

Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling by Hantgan, Roy R, Stahle, Mary C, Connor, John H, Horita, David A, Rocco, Mattia, McLane, Mary A, Yakovlev, Sergiy, Medved, Leonid

“…This study tested the hypothesis that high-affinity binding of macromolecular ligands to the alphaIIbbeta3 integrin is tightly coupled to binding-site…”
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The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization by Hantgan, Roy R, Stahle, Mary C, Connor, John H, Lyles, Douglas S, Horita, David A, Rocco, Mattia, Nagaswami, Chandrasekaran, Weisel, John W, McLane, Mary Ann

“…We have employed echistatin, a 5.4 kDa snake venom disintegrin, as a model protein to investigate the paradox that small ligand-mimetics can bind to the…”
Get full text