Search Results - "Stahlberg, Henning"

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy by Guerrero-Ferreira, Ricardo, Kovacik, Lubomir, Ni, Dongchun, Stahlberg, Henning

“…[Display omitted] •Alpha-synuclein fibril structures determined by cryo-EM are discussed.•We discuss Parkinson’s disease-related aSyn mutations for fibrils.•We…”
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Structural basis for regulation of human acetyl-CoA carboxylase by Hunkeler, Moritz, Hagmann, Anna, Stuttfeld, Edward, Chami, Mohamed, Guri, Yakir, Stahlberg, Henning, Maier, Timm

“…Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis 1 , 2 . Eukaryotic acetyl-CoA…”
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Structural strains of misfolded tau protein define different diseases by Stahlberg, Henning, Riek, Roland

“…In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many…”
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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Arteni, Ana-Andreea, Kumari, Pratibha, Mona, Daniel, Ringler, Philippe, Britschgi, Markus, Lauer, Matthias E, Makky, Ali, Verasdonck, Joeri, Riek, Roland, Melki, Ronald, Meier, Beat H, Böckmann, Anja, Bousset, Luc, Stahlberg, Henning

“…Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease (PD). Previously, we…”
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Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism by Yu, Qin, Ni, Dongchun, Kowal, Julia, Manolaridis, Ioannis, Jackson, Scott M., Stahlberg, Henning, Locher, Kaspar P.

“…ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures,…”
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Structure of the human multidrug transporter ABCG2 by Taylor, Nicholas M. I., Manolaridis, Ioannis, Jackson, Scott M., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.

“…ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the…”
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Cryo-EM structure of alpha-synuclein fibrils by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Mona, Daniel, Ringler, Philippe, Lauer, Matthias E, Riek, Roland, Britschgi, Markus, Stahlberg, Henning

“…Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found…”
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Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states by Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.

“…ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2 by Kowal, Julia, Ni, Dongchun, Jackson, Scott M., Manolaridis, Ioannis, Stahlberg, Henning, Locher, Kaspar P.

“…[Display omitted] •Anticancer drugs interact with key amino acid residues in the binding pocket of ABCG2.•Substrate retains some mobility inside the…”
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Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens by Sedzicki, Jaroslaw, Ni, Dongchun, Lehmann, Frank, Stahlberg, Henning, Dehio, Christoph

“…The synthesis of complex sugars is a key aspect of microbial biology. Cyclic β-1,2-glucan (CβG) is a circular polysaccharide critical for host interactions of…”
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Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools by Hu, Chunyi, Ni, Dongchun, Nam, Ki Hyun, Majumdar, Sonali, McLean, Justin, Stahlberg, Henning, Terns, Michael P., Ke, Ailong

“…Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA. First, an RNA-guided complex named Cascade identifies the complementary DNA…”
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Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range by Ni, Dongchun, Turelli, Priscilla, Beckert, Bertrand, Nazarov, Sergey, Uchikawa, Emiko, Myasnikov, Alexander, Pojer, Florence, Trono, Didier, Stahlberg, Henning, Lau, Kelvin

“…Investigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and…”
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Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1 by Alam, Amer, Küng, Raphael, Kowal, Julia, McLeod, Robert A., Tremp, Nina, Broude, Eugenia V., Roninson, Igor B., Stahlberg, Henning, Locher, Kaspar P.

“…The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and…”
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Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 by Jackson, Scott M., Manolaridis, Ioannis, Kowal, Julia, Zechner, Melanie, Taylor, Nicholas M. I., Bause, Manuel, Bauer, Stefanie, Bartholomaeus, Ruben, Bernhardt, Guenther, Koenig, Burkhard, Buschauer, Armin, Stahlberg, Henning, Altmann, Karl-Heinz, Locher, Kaspar P.

“…ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to…”
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Focus: The interface between data collection and data processing in cryo-EM by Biyani, Nikhil, Righetto, Ricardo D., McLeod, Robert, Caujolle-Bert, Daniel, Castano-Diez, Daniel, Goldie, Kenneth N., Stahlberg, Henning

“…We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing…”
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Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM by Righetto, Ricardo D., Biyani, Nikhil, Kowal, Julia, Chami, Mohamed, Stahlberg, Henning

“…Electron crystallography can reveal the structure of membrane proteins within 2D crystals under close-to-native conditions. High-resolution structural…”
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Structure of the T4 baseplate and its function in triggering sheath contraction by Taylor, Nicholas M. I., Prokhorov, Nikolai S., Guerrero-Ferreira, Ricardo C., Shneider, Mikhail M., Browning, Christopher, Goldie, Kenneth N., Stahlberg, Henning, Leiman, Petr G.

“…Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to…”
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X-ray structure of the mouse serotonin 5-HT3 receptor by Hassaine, Ghérici, Deluz, Cédric, Grasso, Luigino, Wyss, Romain, Tol, Menno B., Hovius, Ruud, Graff, Alexandra, Stahlberg, Henning, Tomizaki, Takashi, Desmyter, Aline, Moreau, Christophe, Li, Xiao-Dan, Poitevin, Frédéric, Vogel, Horst, Nury, Hugues

“…Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of…”
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Structure of the Type VI Secretion System Contractile Sheath by Kudryashev, Mikhail, Wang, Ray Yu-Ruei, Brackmann, Maximilian, Scherer, Sebastian, Maier, Timm, Baker, David, DiMaio, Frank, Stahlberg, Henning, Egelman, Edward H., Basler, Marek

“…Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an…”
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