Search Results - "Stachowiak, M K"

Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1 by Stachowiak, E. K., Benson, C. A., Narla, S. T., Dimitri, A., Chuye, L. E. Bayona, Dhiman, S., Harikrishnan, K., Elahi, S., Freedman, D., Brennand, K. J., Sarder, P., Stachowiak, M. K.

“…Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control individuals revealed that the disorder is programmed at the…”
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TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia by Hauser, T.A., Kucinski, A., Jordan, K.G., Gatto, G.J., Wersinger, S.R., Hesse, R.A., Stachowiak, E.K., Stachowiak, M.K., Papke, R.L., Lippiello, P.M., Bencherif, M.

“…The novel alpha7 neuronal nicotinic receptor-selective agonist TC-5619 demonstrates efficacy in animal models of the positive and negative symptoms and…”
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Schizophrenia: A neurodevelopmental disorder — Integrative genomic hypothesis and therapeutic implications from a transgenic mouse model by Stachowiak, M.K, Kucinski, A, Curl, R, Syposs, C, Yang, Y, Narla, S, Terranova, C, Prokop, D, Klejbor, I, Bencherif, M, Birkaya, B, Corso, T, Parikh, A, Tzanakakis, E.S, Wersinger, S, Stachowiak, E.K

“…Abstract Schizophrenia is a neurodevelopmental disorder featuring complex aberrations in the structure, wiring, and chemistry of multiple neuronal systems. The…”
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cAMP‐induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor‐1 (FGFR1) by Stachowiak, E. K., Fang, X., Myers, J., Dunham, S., Stachowiak, M. K.

“…Activation of cAMP signaling pathway and its transcriptional factor cyclic AMP response element binding protein (CREB) and coactivator are key determinants of…”
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α7 neuronal nicotinic receptor agonist (TC-7020) reverses increased striatal dopamine release during acoustic PPI testing in a transgenic mouse model of schizophrenia by Kucinski, A, Syposs, C, Wersinger, S, Bencherif, M, Stachowiak, M.K, Stachowiak, E.K

“…Abstract Genetic and post mortem evidence has implicated the α7 neuronal nicotinic receptor (NNR) in the etiology of schizophrenia and related disorders. In…”
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Nuclear accumulation of fibroblast growth factor receptors in human glial cells : association with cell proliferation by STACHOWIAK, E. K, MAHER, P. A, TUCHOLSKI, J, MORDECHAI, E, JOY, A, MOFFETT, J, COONS, S, STACHOWIAK, M. K

“…In this study we describe the presence of high affinity FGF-2 binding sites in the nuclei of U251MG glioma cells (K(d)=7 pM). Immunoprecipitation of total cell…”
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Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells by JOY, A, MOFFETT, J, NEARY, K, MORDECHAI, E, STACHOWIAK, E. K, COONS, S, RANKIN-SHAPIRO, J, FLORKIEWICZ, R. Z, STACHOWIAK, M. K

“…FGF-2 has been implicated in the neoplastic transformation of glioma cells and in the transition of normal quiescent astrocytes to a proliferating, reactive…”
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Bone morphogenetic protein‐7 stimulates initial dendritic 
growth in sympathetic neurons through an intracellular 
fibroblast growth factor signaling pathway by Horbinski, C., Stachowiak, E. K., Chandrasekaran, V., Miuzukoshi, E., Higgins, D., Stachowiak, M. K.

“…Bone morphogenetic protein‐7 (BMP‐7), a member of the transforming growth factor (TGF)‐β superfamily of signaling cytokines, induces dendritic growth in rat…”
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Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors by Peng, H, Moffett, J, Myers, J, Fang, X, Stachowiak, E K, Maher, P, Kratz, E, Hines, J, Fluharty, S J, Mizukoshi, E, Bloom, D C, Stachowiak, M K

“…In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene…”
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Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS) by Narla, S.T, Lee, Y-W, Benson, C.A, Sarder, P, Brennand, K.J, Stachowiak, E.K, Stachowiak, M.K

“…Abstract The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified…”
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Brain Organoids: Expanding Our Understanding of Human Development and Disease by Chuye, L B, Dimitri, A, Desai, A, Handelmann, C, Bae, Y, Johari, P, Jornet, J M, Klejbor, I, Stachowiak, M K, Stachowiak, E K

“…Stem cell-derived brain organoids replicate important stages of the prenatal human brain development and combined with the induced pluripotent stem cell (iPSC)…”
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Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism by Stachowiak, M K, Moffett, J, Maher, P, Tucholski, J, Stachowiak, E K

“…This article discusses a novel intracrine mechanism of growth-factor action in the nervous system whereby fibroblast growth factor-2 (FGF-2) and its receptor…”
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Bovine tyrosine hydroxylase gene-promoter regions involved in basal and angiotensin II-stimulated expression in nontransformed adrenal medullary cells by Goc, A, Stachowiak, M K

“…The tyrosine hydroxylase gene is expressed specifically in catecholaminergic cells, and its activity is regulated by afferent stimuli. To characterize…”
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Identification and distribution of Parkin in rat brain by Horowitz, Judith M, Myers, Jason, Stachowiak, Michal K, Torres, German

“…MUTATIONS within the amino acid sequence of Parkin, the encoded protein of the parkin gene, appear to trigger the degeneration of dopaminergic neurons in the…”
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Microinjections of anisomycin into the intermediate cerebellum during learning affect the acquisition of classically conditioned responses in the rabbit by Bracha, Vlastislav, Irwin, Kristina B., Webster, Michelle L., Wunderlich, David A., Stachowiak, Michal K., Bloedel, James R.

“…The purpose of this study was to examine the effects of protein synthesis inhibition in the intermediate cerebellum on the acquisition and expression of…”
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ORMOSIL nanoparticles as a non-viral gene delivery vector for modeling polyglutamine induced brain pathology by Klejbor, I., Stachowiak, E.K., Bharali, D.J., Roy, I., Spodnik, I., Morys, J., Bergey, E.J., Prasad, P.N., Stachowiak, M.K.

“…Studies have shown the presence of expanded polyQ containing proteins in brain cells related to Huntington disease (HD) and other poly-glutamine disorders. We…”
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Promoter Regions Involved in Density-Dependent Regulation of Basic Fibroblast Growth Factor Gene Expression in Human Astrocytic Cells by Moffett, John, Kratz, Erica, Florkiewicz, Robert, Stachowiak, Michal K.

“…Expression of mitogenic basic fibroblast growth factor (bFGF) in the central nervous system is inhibited by direct cell contact and is implicated in reactive…”
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Increased dopamine release from striata of rats after unilateral nigrostriatal bundle damage by Zhang, W Q, Tilson, H A, Nanry, K P, Hudson, P M, Hong, J S, Stachowiak, M K

“…Dopaminergic control of striatal neurons is retained in rats sustaining lesions of the nigrostriatal bundle (NSB) as long as 10% of the projection remains,…”
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Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action by Stachowiak, M.K., Maher, P.A., Joy, A., Mordechai, E., Stachowiak, E.K.

“…Fractionation of human astrocytes revealed the presence of 103, 118, and 145 kDa forms of FGF receptor 1 (FGFR1) in isolated nuclei. Only trace amounts of…”
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Cruciform-extruding regulatory element controls cell-specific activity of the tyrosine hydroxylase gene promoter by Kim, Ella L., Peng, Hu, Esparza, Frederico M., Maltchenko, Sergei Z., Stachowiak, Michal K.

“…Tyrosine hydroxylase (TH) is expressed specifically in catecholaminergic cells. We have identified a novel regulatory sequence in the upstream region of the…”
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